
中国科学院生物物理研究所,表观遗传调控与干预全国重点实验室,研究组长
1994.09 - 1998.07 烟台大学,学士学位
1998.09 - 2003.07 中国科学院生物物理所,博士研究生
2003.11 - 2005.04 密西根大学,博士后
2005.05 - 2006.07 耶鲁大学医学院,博士后
2006.08 - 2009.07 芝加哥大学,研究助理
2009.07 - 2023.06 中国科学院北京基因组研究所。研究员
2023.06 - 至今 中国科学院生物物理研究所,研究员
2014年 中国科学院青年科学家奖,中国科学院
2014年 杰出青年基金获得者,国家自然科学基金委员会
2014年、2020年 朱李月华导师奖,中国科学院
2015年 第三世界科学院青年通讯会士(TWAS Young Affiliate)
2015年 李汝祺动物遗传奖,中国遗传学会
2015、2016、2019、2020年 中国科学院优秀导师奖,中国科学院
2016年 政府特殊津贴专家,中华人民共和国国务院
2017年 国家百千万人才工程"有突出贡献中青年专家",中华人民共和国人力资源和社会保障部
2018年 "新时代科技报国"优秀共产党员,中共中国科学院党组
2018年 谈家桢生命科学创新奖,谈家桢生命科学奖奖励委员会
2020年 第八届中国侨界贡献奖,中华全国归国华侨联合会
2009 - Genomics, Proteomics & Bioinformatics 编委
1. 表观遗传信息调控胚胎发育
表观遗传信息调控基因的表达和胚胎的发育。研究团队在建立新的表观遗传时空组学技术,研究表观遗传信息在胚胎发育和器官建立过程中的重编程动态变化,并揭示调控表观遗传重编程的分子机制,进而解析不同表观遗传调控信息对胚胎发育及器官建立的调控作用。
2. 表观遗传信息在生殖医学的临床应用
团队在国际上首创了使用DNA甲基化筛选胚胎的方法,近期我们在与生殖中心合作进行多中心随机对照临床试验。我们将结合人工智能等方法,建立筛选优质胚胎提高试管婴儿出生率的临床标准。同时我们还研究其它的改善辅助生殖的方法和技术。我们致力于将基础研究转化到临床中,帮助不孕不育患者获得后代,并减少出生缺陷的比例。
1. Zhenping Chen(陈振平), Maoni Guo(郭毛妮), Lin Zhang(张林), Hao Yu(喻昊), Xinxin Wang(王欣欣), Xinrui Yu, Mingyue Chen(陈明月), Junjie Lv(吕俊杰), Zhisong Chen(陈智松), Changjun Peng(彭长军), Qian Gong(龚倩), Qiao Zhang(张乔), Ru Guo(郭茹), Yiping Huang(黄伊萍), Lei Gao(高磊), Shan Jiang(姜姗), Junmei Wang(王俊梅), Zhihua Zhang(张治华), Jianliang Qian, Jianrong Wang, Jiang Liu(刘江)*, Xuepeng Chen(陈雪鹏)*. Spatially resolved chromatin architectures in mammalian brain tissues. Nature methods. 2026, doi.org/10.1038/s41592-026-03218-3
2. Xun Shan, Yimin Tang, Jinzhou Hu, Mingyuan Bian, Xuelong Yao, Lei Gao*, Jiang Liu*, Spatial 5mC-seq profiling of embryos and decidua after implantation in mammals. Nature methods 2026, 23, 924-934.
3. Shan Jiang, Hao Yu, Ting Zhao, Yao Lu, Xuesong Li, Lei Gao, Jie Mi, Wenzhe Xia, Lanjun Geng, Panpan Li, Mingyue Chen, Mengyao Kang, Jiang Liu*, Yuwen Ke*, A high-definition spatiotemporal transcriptomic atlas of mammalian kidney development. Innovation, 2025, 6, 100767.
4. Chao Ning, Xi Wu, Xudong Zhao, Zongyang Lu, Xuelong Yao, Tao Zhou, Lizhi Yi, Yaoyu Sun, Shuaishuai Wu, Zhenbo Liu, Xingxu Huang*, Lei Gao*, Jiang Liu*, The epigenomic landscapes during prefrontal cortex development and aging in rhesus. National Science Review, 2024, doi.org/10.1093/nsr/nwae213
5. Jianhong Zhan*, Chuangqi Chen, Na Zhang, Shuhuai Zhong, Jiaming Wang, Jinzhou Hu, Jiang Liu*, An artificial intelligence model for embryo selection in preimplantation DNA methylation screening in assisted reproductive technology. Biophysics Reports. 2023, 9(6):352?361
6. Keliang Wu, Dongdong Fan, Han Zhao, ZhenboLiu, Zhenzhen Hou, Wenrong Tao, Guanling Yu, Shenli Yuan, Xiaoxiao Zhu, Mengyao Kang, Yong Tian*, Zi-Jiang Chen*, Jiang Liu* and Lei Gao*. Dynamics of histone acetylation during human early embryogenesis. Cell discovery, 2023, 9, 29.
7. Shan Jiang, Zheng Huang, Yun Li, Chengwei Yu, Hao Yu, Yuwen Ke, Lan Jiang*, and Jiang Liu*, Single-cell chromatin accessibility and transcriptome atlas of mouse embryos. Cell reports. 2023, 42, 112210.
8. Yuan Gao*, Lizhi Yi, Jianhong Zhan, Lijuan Wang, Xuelong Yao, Junhao Yan, Sijing Jian, Lei Gao, Mamadboqirova Farangez, Ming Gao, Yang Zou, Xuan Gao, Keliang Wu, Jiang Liu*, and Zi-Jiang Chen*. A clinical study of preimplantation DNA methylation screening in assisted reproductive technology. Cell Research. 2023, May; 33: 483-485
9. Xuelong Yao, Zongyang Lu, Zhanying Feng, Lei Gao, Xin Zhou, Min Li, Suijuan Zhong, Qian Wu, Zhenbo Liu , Haofeng Zhang, Zeyuan Liu, Lizhi Yi, Tao Zhou, Xudong Zhao, Jun Zhang, Yong Wang, Xingxu Huang*, Xiaoqun Wang* & Jiang Liu*. Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human. Nature Communications, 2022,13:3883
10. Xinxin Wang, Xin Ma, Gaobo Wei, Weirui Ma, Zhen Zhang, Xuepeng Chen, Lei Gao, Zhenbo Liu, Yue Yuan, Lizhi Yi, Jun Wang, Toshinobu Tokumoto, Junjiu Huang, Dahua Chen*, Jian Zhang*, Jiang Liu*. The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish. Genomics Proteomics & Bioinformatics, 2021, 19(1):48-63
11. Xuepeng Chen, Yuwen Ke, Keliang Wu, Han Zhao, Yaoyu Sun, Lei Gao, Zhenbo Liu, Jingye Zhang, Wenrong Tao, Zhenzhen Hou, Hui Liu, Jiang Liu*, Zi-Jiang Chen*. Key role for CTCF in establishing chromatin structure in human embryos. Nature, 2019, 576:306-310
12. Xiaocui Xu, Guoqiang Li, Congru Li, Jing Zhang, Qiang Wang, David K. Simmons, Xuepeng Chen, Naveen Wijesena, Wei Zhu, Zhanyang Wang, guoNeelakanteswar Aluru, Paola Oliveri, Yong E. Zhang, Mark Q. Martindale and Jiang Liu*, Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis. National Science Review, 2019, doi: 10.1093/nsr/nwz064
13. Lei Gao, Keliang Wu, Zhenbo Liu, Xuelong Yao, Shenli Yuan, Wenrong Tao, Lizhi Yi, Guanling Yu, Zhenzhen Hou, Dongdong Fan, Yong Tian, Jianqiao Liu*, Zi-Jiang Chen*, and Jiang Liu*. Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution. Cell, 2018, 173, 248-259
14. Congru Li, Yong Fan, Guoqiang Li, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Yang Yu*, Jiang Liu*. DNA methylation reprogramming of functional elements during mammalian embryonic development. Cell Discovery, 2018, 4:41
15. Yuwen Ke, Yanan Xu, Xuepeng Chen, Songjie Feng, Zhenbo Liu, Yaoyu Sun, Xuelong Yao, Fangzhen Li, Wei Zhu, Lei Gao, Haojie Chen, Zhenhai Du, Xie Wei, Xiaocui Xu, Xingxu Huang*, Jiang Liu*. 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis, Cell, 2017, 170, Jul 13;170(2):367-381.e20
16. Guoqiang Li, Yang Yu, Yong Fan, Congru Li, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao*, Jiang Liu*, Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology, Journal of Genetics and Genomics, 2017, Oct 20; 44 (10): 475-481.
17. Ke Chen, Jing Zhang, Zhongqiang Guo, Qin Ma, Zhengzheng Xu, Yuanyuan Zhou, Zhiying Xu, Zhongwu Li, Yiqiang Liu, Xiongjun Ye, Xuesong Li, Bifeng Yuan, Yuwen Ke, Chuan He, Liqun Zhou*, Jiang Liu* and Weimin Ci*. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer, Cell Research, 2016, Jan; 26(1):103-18
18. Yunfang Wang*, Jinhua Qin, Shuyong Wang, Wencheng Zhang, Jialei Duan, Jing Zhang, Xin Wang, Fang Yan, Mingyang Chang, Xiaofang Liu, Bo Feng, Jiang Liu*, Xuetao Pei*, Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules, Cell Stem Cell, 2016, Oct 6; 19 (4); 449-461, * co-senior author
19. Zhong-Qiang Guo, Tong Zheng, Baoen Chen, Cheng Luo, Sisheng Ouyang, Shouzhe Gong, Jiafei Li, Liu-Liang Mao, Fulin Lian, Yong Yang, Yue Huang, Li Li, Jing Lu, Bidong Zhang, Luming Zhou, Hong Ding, Zhiwei Gao, Liqun Zhou, Guoqiang Li, Ran Zhou, Ke Chen, Jingqiu Liu, Yi Wen, Likun Gong, Yuwen Ke, Shang-Dong Yang, Xiao-Bo Qiu, Naixia Zhang, Jin Ren, Dafang Zhong, Cai-Guang Yang,* Jiang Liu,* and Hualiang Jiang*. Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer, Cancer Cell, 2016, 30(3), 474-484 (highlighted by Nature Reviews Urology)
20. Lu Wang, Jun Zhang, Jialei Duan, Xinxing Gao, Wei Zhu, Xingyu Lu, Lu Yang, Jing Zhang, Guoqiang Li, Weimin Ci, Wei Li, Qi Zhou, Neel Aluru, Fuchou Tang, Chuan He, Xingxu Huang*, Jiang Liu*, Programming and inheritance of parental DNA methylomes in mammals, Cell, 2014, 157(4),979-991
21. Guoqiang Li, Weimin Ci, Subhradip Karmakar, Ke Chen, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Xianghong Li, Erin E. Mowers, Matthew F. Calabrese, Edmond R. Watson, Sandip Prasad, Carrie Rinker-Schaeffer, Scott E. Eggener, Thomas Stricker, Yong Tian, Brenda Schulman, Jiang Liu*, Kevin P. White*, SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer, Cancer Cell, 2014, 25(4), 455-468.
22. Lan Jiang, Jing Zhang, Jing-Jing Wang, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci*, Jiang Liu*. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos, Cell, 2013, 153(4), 773-84, (Cover story,highlighted by Cell, Nature Review Genetics)
23. Jiang Liu#, Murad Ghanim#, Lei Xue#, Ivan Iossifov, Cesar Angeletti, Sujun Hua, Nicolas Negre, Michael Ludwig, Thomas Stricker, Hikmat A. Al-Ahmadie, Maria Tretiakova, Robert L. Camp, Montse Perera-Alberto, David L. Rimm, Tian Xu, Andrey Rzhetsky and Kevin P. White. 2009. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer, Science, 2009, 323(5918):1218-1222
(资料来源:刘江研究员,2026-10-26)