
国家“优秀青年基金”获得者 中国科学院生物物理研究所,生物大分子全国重点实验室,研究组长
2005.09 - 2009.07 中国矿业大学(北京),生物工程,工学学士
2009.09 - 2014.07 中国科学院生物物理研究所,细胞生物学,理学博士
2014.08 - 2017.12 中国科学院生物物理研究所,“MI计划”博士后,副研究员(资格)
2018.01 - 2019.07 中国科学院生物物理研究所,副研究员
2019.07 - 至今 中国科学院生物物理研究所,研究员
2022-2025 科睿唯安全球高被引学者Clarivate Highly Cited Researcher
2021-2026 斯坦福大学2%顶尖科学家
2024年 ScholarGPS 全球前 0.05%顶尖学者榜单
2023年 潍坊在外杰出青年
2023年 中源协和生命医学创新突破奖
2023年 北京朝阳"凤凰计划"高层次人才
2022年 中国发明协会"发明创业创新"一等奖
2019年 贝时璋青年生物物理学家奖
2019年 中国科学院青年创新促进会会员
2019年 中国医师协会优秀青年科技工作者
2019年 全国创新创业类"向上向善好青年"
2017年 19th IUPAB Young Scientist Travel Award
2016年 中国科协"青年人才托举工程"
Exploration创刊副主编
中国生物物理学会理事
中国生物物理学会纳米酶分会委员
中国生物物理学会纳米酶分会秘书长
中国生物物理学会纳米生物学分会委员
中国生物物理学会生物微量元素分会常务委员
中国生物材料学会青年工作委员会委员
中国生物材料学会体外诊断生物材料分会委员
中国医药生物技术协会生物医学成像技术分会委员
中国医师协会介入医师分会委员
中国抗癌协会纳米肿瘤专业委员会委员
中国生物物理学会材料生物学与智能诊疗分会委员会委员
北京老年医院神经医学中心特聘教授
1. 高活性纳米酶的理性设计和纳米酶构-效关系研究。首次提出模拟天然酶活性中心、仿生设计和优化纳米酶的新理念,实现超越天然酶的高活性纳米酶设计。
2. 铁蛋白纳米酶和肿瘤诊断与催化治疗研究。首次发现铁蛋白是TfR1的新配体,能够识别肿瘤组织和穿越血脑屏障;设计铁蛋白纳米酶探针,创制肿瘤免疫诊断新方法;发展纳米酶肿瘤催化治疗新策略和恶性脑疟治疗新方法。
3. 铁蛋白纳米药物载体研究。首次发现铁蛋白存在温度敏感型药物通道,发展铁蛋白纳米药物载体,实现核酸药物装载的突破,推动铁蛋白药物载体的产业化。
1. Ruofei Zhang, Hanqing Zhao, Sijie Zhang, Xiyun Yan*, Kelong Fan*. Standardized assays for evaluating superoxide dismutase-like and catalase-like activities of nanozymes. Nature Protocols, 2026.
2. Xiaoyong Zhang, Hang Yu, Kai Zhu, Yao Xiao, Yuxuan Gong, Dandan Che, Wanyi Chen, Guoxing You, Xiyun Yan, Quan Wang*, Kelong Fan*, Hong Zhou*, Gan Chen*. Self-adaptive nanozymes with enhanced multi-enzyme activities for sequential multimodal therapy of drug-resistant bacteria-infected wounds. Nature Communications, 2026, 17:6935.
3. Shuai Zhang, Yiliang Jin, Yaxin Hou, Guoheng Tang, Zhuoran Wang, Xuehui Chen*, Xiyun Yan*, Kelong Fan*. Bioengineered ferritin-based lysosome-targeting chimera platform for tumor-targeted therapy. Nature Communications, 2026, 17:3706.
4. Yixin Yu, Ran Xu, Xuetong Wu, Bilian Wang*, Mingzhen Zhang*, Kelong Fan*. A Spin-Engineered Nanozyme Overcomes the Activity-Selectivity Trade-Off for Sustainable Adhesive Production From Lignin Biomass Conversion. Advanced Materials, 2026, 38(7):e17928.
5. Qihang Ding, Kai Liao, Kunxiu Zhang, Mingzhen Zhang*, Ling Mei*, Kelong Fan*. Beyond Enzyme Mimics: Engineering Photo-Responsive Nanozymes for Therapeutic Innovation. Advanced Materials, 2025, 38(3):e10661.
6. Haolun Gu, Jingqi Li, Pengyu Dai, Tiedong Sun*, Chunxia Chen*, Zhong Guo*, Kelong Fan*, Polyphenol Oxidase-Like Nanozymes. Advanced Materials, 2025, e09346.
7. Yaxin Hou, Guoheng Tang, Qizhi Wang, Meng Zhou, Ran Xu, Xuehui Chen, Guizhi Shi, Zhuoran Wang, Xiyun Yan*, Jie Zhuang*, Kelong Fan*. Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations. Signal Transduction and Targeted Therapy, 2025, 10(1): 212.
8. Ruofei Zhang, Xiyun Yan, Lizeng Gao*, Kelong Fan*. Nanozymes expanding the boundaries of biocatalysis, Nature Communications, 2025, 16(1): 6817.
9. Yiliang Jin, Baoli Zhang, Jianru Li, Zhenxi Guo, Chen Zhang, Xuehui Chen, Long Ma, Zhuoran Wang, Haiyin Yang, Yong Li, Yuhua Weng, Yuanyu Huang, Xiyun Yan*, Kelong Fan*, Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma. Science Advances. 2025, 11(8): eadr9266.
10. Long Ma, Zimo Liang, Yinyin Hou, Ruofei Zhang, Kelong Fan*, Xiyun Yan*,Nanozymes and Their Potential Roles in the rigin of Life. Advanced Materials. 2025, 37 (6): 2412211.
11. Zheng Li, Xiaowan Fan, Ying Liu, Muxin Yue, Tingting Wu, Xing Wang*, Wei Jiang*, Kelong Fan*, Engineering Mild-Photothermal Responsive and NO Donor Prussian Blue Nanozymes Using Mild Synthesis for Inflammation Regulation and Bacterial Eradication in Periodontal Disease. Advanced Materials. 2025, 37 (6): 2409840.
12. Ruofei Zhang, Yanfang Shen, Xiaoying Zhou, Jianru Li, Hanqing Zhao, Zixia Zhang, Jun Zhao, Hongjun Jin, Shuanshuan Guo, Hui Ding, Guohui Nie, Zhe Zhang*, Ying Wang*, Xiyun Yan*, Kelong Fan*, Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization. Nature Communications, 2025, 16(1): 890.
13. Ruofei Zhang, Bing Jiang, Kelong Fan*, Lizeng Gao*, Xiyun Yan*. Designing nanozymes for in vivo applications. Nature Reviews Bioengineering. 2024, 2(10): 849-868.
14. Jingqi Li, Xinda Cai, Peng Jiang, Huayuan Wang, Shiwei Zhang, Tiedong Sun*, Chunxia Chen*, Kelong Fan*. Co-based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences. Advanced Materials. 2024, 36(8): 2307337.
15. Daji Wang*, Jie Wang*, Xuejiao J. Gao, Hui Ding, Ming Yang, Zhiheng He, Jiaying Xie, Zixia Zhang, Haibing Huang, Guohui Nie*, Xiyun Yan*, Kelong Fan*. Employing Noble Metal-Porphyrins to Engineer Robust and Highly Active Single-Atom Nanozymes for Targeted Catalytic Therapy in Nasopharyngeal Carcinoma. Advanced Materials. 2024, 36(7): 2310033.
16. Zhuoran Wang, Yue Zhao, Yaxin Hou, Guoheng Tang, Ruofei Zhang, Yili Yang, Xiyun Yan*, Kelong Fan*. A Thrombin-Activated Peptide-Templated Nanozyme for Remedying Ischemic Stroke via Thrombolytic and Neuroprotective Actions. Advanced Materials. 2024, 36 (10): 2210144. (Recommended in Faculty Opinions)(ESI高被引论文)
17. Xiangqin Meng, Huizhen Fan, Lei Chen, Jiuyang He, Chaoyi Hong, Jiaying Xie, Yinyin Hou, Kaidi Wang, Xingfa Gao, Lizeng Gao, Xiyun Yan*, Kelong Fan*. Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy. Nature Communications. 2024, 15: 1626.
18. Long Ma, Jia-Jia Zheng, Ning Zhou, Ruofei Zhang, Long Fang, Yili Yang, Xingfa Gao, Chunying Chen, Xiyun Yan*, Kelong Fan*. A natural biogenic nanozyme for scavenging superoxide radicals. Nature Communications. 2024,15: 233. (Featured Article selected by Editors of NC).
19. Wei Jiang, Qing Li*, Ruofei Zhang, Jianru Li, Qianyu Lin, Jingyun Li, Xinyao Zhou, Xiyun Yan*, Kelong Fan*. Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson's disease. Nature Communications, 2023, 14: 8137.
20. Huizhen Fan, Jiajia Zheng, Jiaying Xie, Juewen Liu, Xingfa Gao, Xiyun Yan, Kelong Fan, Lizeng Gao*, Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay, Advanced Materials. 2023, 36(10): 2300387.
21. Yongjuan Li, Yu Zhang, Ya Dong, Ozioma Udochukwu Akakuru, Xiaohan Yao, Jinmeng Yi, Xinyan Li, Linlin Wang, Xiaohan Lou, Baoyu Zhu, Kelong Fan*, Zhihai Qin*. Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme-Mediated Catalytic/Starvation/Mild-Temperature Photothermal Therapy. Advanced Materials. 2023, 35(22): 2210464.
22. Wenhui Gao, Jiuyang He, Lei Chen, Xiangqin Meng, Yana Ma, Liangliang Cheng, Kangsheng Tu, Xingfa Gao, Cui Liu*, Mingzhen Zhang*, Kelong Fan*, Dai-Wen Pang*, Xiyun Yan*. Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme. Nature Communications. 2023, 14: 160. (Featured Article Selected by Editors of NC)(ESI高被引论文)
23. Ruofei Zhang#, Bai Xue#, Yanhong Tao#, Hanqing Zhao, Zixia Zhang, Xiaonan Wang, Xinyao Zhou, Bing Jiang, Zhenglin Yang*, Xiyun Yan*, and Kelong Fan*. Edge-site Engineering of Defective Fe-N4 nanozymes with Boosted Catalase-like Performance for Retinal Vasculopathies. Advanced Materials. 2022, 34(39): 2205324.(ESI高被引论文)
(资料来源:范克龙研究员,2026-10-22)