Protein & Cell, 21 August, 2026, DOI：https://doi.org/10.1093/procel/pwag056
Isolation and proteomics of human skeletal muscle lipid droplets identify anchored mitochondria and associated TPD52L2
Xiaochuan Fu, Zhihua Zhang, Lijun Jiang, Qiumin Liao, Yilu Xu, Yang Wang, Zhen Cao, Jifeng Wang, Xiaojuan Wei, Yan Gao, Yue Li, Haijun Wang, Yin Pei, Fan Hu, Shuyan Zhang, Hongchao Zhang, Xin Zhang, Pingsheng Liu
Abstract
Skeletal muscle is the executing organ of animal physical activity and postural maintenance, and uses glucose and fatty acids (FA) that are stored in triacylglycerol (TAG) in lipid droplets (LDs) as an energy source. Skeletal muscle accounts for over 80% of postprandial glucose disposal, and its insulin resistance is widely recognized as a pivotal etiological factor in the development of type 2 diabetes mellitus (T2DM) (Merz and Thurmond, 2020). Insulin sensitivity in skeletal muscle is closely linked to LD dynamics that play central roles in lipid storage and metabolic regulation (Olzmann and Carvalho, 2019; Xu et al., 2018). Previous studies have demonstrated that LDs are present within human skeletal muscle fibers, and their accumulation as intramyocellular lipids (IMCL) is generally associated with reduced skeletal muscle insulin sensitivity (Pan et al., 1997; Phillips et al., 1996). Despite extensive morphological studies linking LD characteristics to insulin sensitivity, the absence of LD proteomic data from human skeletal muscle has hindered understanding of their role in insulin resistance and delayed therapeutic development.
文章链接：https://academic.oup.com/proteincell/advance-article/doi/10.1093/procel/pwag056/8767766
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