Cell Research, Vol 67, No 9, pp. 1178–1181, 7 July 2017, DOI: 10.1038/cr.2017.86
Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding
Jiping Yang, Jingyi Li, Keiichiro Suzuki, Xiaomeng Liu, Jun Wu, Weiqi Zhang, Ruotong Ren, Weizhou Zhang, Piu Chan, Juan Carlos Izpisua Belmonte, Jing Qu, Fuchou Tang & Guang-Hui Liu
Abstract
Cell replacement therapy holds great therapeutic promise towards restoring tissue homeostasis. However, aging-associated functional decay and neoplastic transformation following transplantation must be overcome before cell therapies can be effectively and safely implemented in the clinical settings. This goal can theoretically be achieved by developing enhancement strategies towards endowing stem cells with more robust regenerative capacities and concomitantly, a reduced risk for tumorigenesis. Here, we provide an experimental and conceptual strategy on how to genetically engineer superior and safer stem cells.
文章链接：http://www.nature.com/articles/cr201786
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