SCFSlmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila, Cell Research,  advance online publication 19 December 2014

Cell Research advance online publication 19 December 2014; doi: 10.1038/cr.2014.166

SCF^Slmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila

Hongtao Zhang1,2,*, Changqing Li1,*, Hanqing Chen1,2, Chuanxian Wei1,2, Fei Dai1,2, Honggang Wu1,2, Wen Dui1,2, Wu-Min Deng3 and Renjie Jiao1,4

Abstract

Deregulation of the evolutionarily conserved Hippo pathway has been implicated in abnormal development of animals and in several types of cancer. One mechanism of Hippo pathway regulation is achieved by controlling the stability of its regulatory components. However, the executive E3 ligases that are involved in this process, and how the process is regulated, remain poorly defined. In this study, we identify, through a genetic candidate screen, the SCFSlmb E3 ligase as a novel negative regulator of the Hippo pathway in Drosophila imaginal tissues via mediation of the degradation of Expanded (Ex). Mechanistic study shows that Slmb-mediated degradation of Ex is inhibited by the Hippo signaling. Considering the fact that Hippo signaling suppresses the transcription of ex, we propose that the Hippo pathway employs a double security mechanism to ensure fine-tuned homeostasis during development.

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文章链接：http://www.nature.com/cr/journal/vaop/ncurrent/full/cr2014166a.html