Autophagy，Published Online，9.27.2013
Autophagy activity contributes to programmed cell death in Caenorhabditis elegans
Haibin Wang, Qun Lu, Shiya Cheng, Xiaochen Wang, Hong Zhang*
Abstract
The physiological relationship between autophagy and programmed cell death during C. elegans development is poorly understood. In C. elegans, 131 somatic cells and a large number of germline cells undergo programmed cell death. Autophagy genes function in the removal of somatic cell corpses during embryogenesis. Here we demonstrated that autophagy activity participates in germ-cell death induced by genotoxic stress. Upon γ ray treatment, fewer germline cells execute the death program in autophagy mutants. Autophagy also contributes to physiological germ-cell death and post-embryonic cell death in ventral cord neurons when ced-3 caspase activity is partially compromised. Our study reveals that autophagy activity contributes to programmed cell death during C. elegans development.
相关报道：http://www.ibp.cas.cn/kyjz/zxdt/201311/t20131106_3968663.html
文章链接：https://www.landesbioscience.com/journals/autophagy/article/26152/
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