高磊 / 博士 项目研究员
中国科学院青年创新促进会会员 中国科学院生物物理研究所，表观遗传调控与干预重点实验室
简历
2004.09 - 2008.07 武汉大学生命科学学院 理学学士
2008.09 - 2015.07 中国科学院大学上海生命科学研究院健康科学研究所 发育生物学博士
2015.07 - 2019.10 中国科学院北京基因组研究所（国家生物信息中心） 助理研究员
2019.10 - 2023.03 中国科学院北京基因组研究所（国家生物信息中心） 副研究员
2023.03 - 2023.06 中国科学院北京基因组研究所（国家生物信息中心） 青年研究员
2023.06 - 至今 中国科学院生物物理研究所 项目研究员
获奖及荣誉
社会任职
承担项目情况
1. 中国科学院面上项目，32471502，空间单细胞DNA甲基化和羟甲基化测序技术的开发，2025.01-2028.12，项目负责人
2. 国家重点研发计划，2022YFC2703302，常见早孕期超声异常的临床队列建设、染色体及单基因变异诊断新技术和临床干预研究，2022.12-2025.11，课题骨干
3. 中国科学院战略性先导科技专项(B类)，XDB38020500，基因组修饰多维组学分析技术与标准化研究，2020.01-2024.12，课题骨干
4. 中国科学院青年创新促进会项目，2020000011，2020.01-2023.12，项目负责人
5. 国家自然科学基金青年科学基金项目，31601052，细胞周期中全基因组DNA甲基化遗传的时序分析，2017.01-2019.12，项目负责人
聚焦胚胎发育的表观遗传调控研究：
（1）揭示人类早期胚胎发育中合子基因组激活的调控机制（Cell 2018, Cell Discovery 2023a, Cell Discovery 2023b, Natl Sci Rev 2024a）
（2）揭示灵长类前额叶发育的表观调控规律，为阐明人与非人灵长类在认知能力上的差异机制提供潜在理论依据（Natl Sci Rev 2024b, Nat Commun 2022）
1. Chao Ning#, Xi Wu#, Xudong Zhao, Zongyang Lu, Xuelong Yao, Tao Zhou, Lizhi Yi, Yaoyu Sun, Shuaishuai Wu, Zhenbo Liu, Xingxu Huang*, Lei Gao*, Jiang Liu*. Epigenomic landscapes during prefrontal cortex development and aging in rhesus. Natl Sci Rev, 2024; 11(8):nwae213.
2. Shenli Yuan#, Lei Gao#*, Wenrong Tao#, Jianhong Zhan#, Gang Lu#, Jingye Zhang, Chuanxin Zhang, Lizhi Yi, Zhenbo Liu, Zhenzhen Hou, Min Dai, Han Zhao, Zi-Jiang Chen*, Jiang Liu*, Keliang Wu*. Allelic reprogramming of chromatin states in human early embryos. Natl Sci Rev, 2024; 11(3):nwad328.
3. Keliang Wu#, Dongdong Fan#, Han Zhao, Zhenbo Liu, Zhenzhen Hou, Wenrong Tao, Guanling Yu, Shenli Yuan, Xiaoxiao Zhu, Mengyao Kang, Yong Tian*, Zi-Jiang Chen*, Jiang Liu*, Lei Gao*. Dynamics of histone acetylation during human early embryogenesis. Cell Discovery. 2023; 9(1):29.
4. Shenli Yuan#, Jianhong Zhan#, Jingye Zhang#, Zhenbo Liu, Zhenzhen Hou, Chuanxin Zhang, Lizhi Yi, Lei Gao*, Han Zhao*, Zi-Jiang Chen*, Jiang Liu*, Keliang Wu*. Human zygotic genome activation is initiated from paternal genome. Cell Discovery. 2023; 9(1):13.
5. Xuelong Yao#, Zongyang Lu#, Zhanying Feng#, Lei Gao#, Xin Zhou, Min Li, Suijuan Zhong, Qian Wu, Zhenbo Liu, Haofeng Zhang, Zeyuan Liu, Lizhi Yi, Tao Zhou, Xudong Zhao, Jun Zhang, Yong Wang, Xingxu Huang*, Xiaoqun Wang*, Jiang Liu*. Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human. Nat Commun. 2022; 13(1):3883.
6. Lei Gao#, Keliang Wu#, Zhenbo Liu, Xuelong Yao, Shenli Yuan, Wenrong Tao, Lizhi Yi, Guanling Yu, Zhenzhen Hou, Dongdong Fan, Yong Tian, Jianqiao Liu*, Zi-Jiang Chen*, Jiang Liu*. Chromatin Accessibility Landscape in Human Early Embryos and its Association with Evolution. Cell, 2018; 173(1):248-259.
7. Lei Gao, Dantong Li, Ke Ma, Wenjuan Zhang, Tao Xu, Cong Fu, Changbin Jing, Xiao-E Jia, Shuang Wu, Xin Sun, Mei Dong, Min Deng, Yi Chen, Wenger Zhu, Jinrong Peng, Fengyi Wan, Yi Zhou, Leonard I. Zon, Weijun Pan. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genetics, 2015; 11(7):e1005346.
8. Yuan Gao#*, Lizhi Yi#, Jianhong Zhan#, Lijuan Wang#, Xuelong Yao#, Junhao Yan, Sijing Jian, Lei Gao, Mamadboqirova Farangez, Ming Gao, Yang Zou, Xuan Gao, Keliang Wu, Jiang Liu*, Zi-Jiang Chen*. A clinical study of preimplantation DNA methylation screening in assisted reproductive technology. Cell Res, 2023; 33(6):483-485.
9. Xinxin Wang#, Xin Ma#, Gaobo Wei#, Weirui Ma, Zhen Zhang, Xuepeng Chen, Lei Gao, Zhenbo Liu, Yue Yuan, Lizhi Yi, Jun Wang, Toshinobu Tokumoto, Junjiu Huang, Dahua Chen*, Jian Zhang*, Jiang Liu*. The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish. Genomics Proteomics Bioinformatics, 2021 Feb;19(1):48-63.
10. Tao Huang#, Shenli Yuan#, Lei Gao, Mengjing Li, Xiaochen Yu, Jianhong Zhan, Yingying Yin, Chao Liu, Chuanxin Zhang, Gang Lu, Wei Li, Jiang Liu*, Zi-Jiang Chen*, Hongbin Liu*. The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair. Elife, 2020; 9:e53459.
11. Xuepeng Chen#, Yuwen Ke#, Keliang Wu#, Han Zhao#, Yaoyu Sun, Lei Gao, Zhenbo Liu, Jingye Zhang, Wenrong Tao, Zhenzhen Hou, Hui Liu, Jiang Liu*, Zi-Jiang Chen*. Key role for CTCF in establishing chromatin structure in human embryos. Nature, 2019; 576(7786):306-310.
12. Dantong Li#, Wenzhi Xue#, Mei Li#, Mei Dong, Jianwei Wang, Xianda Wang, Xiyue Li, Kai Chen, Wenjuan Zhang, Shuang Wu, Yingqi Zhang, Lei Gao, Yujie Chen, Jianfeng Chen, Bo O Zhou, Yi Zhou, Xuebiao Yao, Lin Li, Dianqing Wu, Weijun Pan. VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Nature, 2018; 564(7734):119-124.
13. Yuwen Ke#, Yanan Xu#, Xuepeng Chen#, Songjie Feng, Zhenbo Liu, Yaoyu Sun, Xuelong Yao, Fangzhen Li, Wei Zhu, Lei Gao, Haojie Chen, Zhenhai Du, Wei Xie, Xiaocui Xu, Xingxu Huang*, Jiang Liu*. 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis. Cell, 2017; 170(2): 367-381.
（资料来源：高磊，2024-11-25）