Members

Institution: Institute of Biophysics, Chinese Academy of Sciences

Address: Room8201, 15 Datun Road, Chaoyang District, Beijing 100101, P.R.China

Phone: +86-10-64888137

Email: pangxy@ibp.ac.cn

Education

Ph.D. 2011-2015, Institute of Biophysics, Chinese Academy of Sciences, Beijing

M.S. 2004-2007, Laboratory of Structural Biology, School of Life Sciences & Department of Medical School, Tsinghua University, Beijing

B.S.1999-2003, School of Life Sciences, Shandong University, Jinan

Research Field and Experience

2009.9 –Present, Institute of Biophysics, Chinese Academy of Sciences,

      Studies on membrane remodeling by small GTPase proteins by electron microscopy,

      Structural and functional studies on ACAP1 in endocytic recycling by X-ray crystallography and Cryo-Electron Microscopy, 

       Studies on membrane remodeling by BAR domain proteins by electron microscopy

2007.7 – 2009.8, Institute of Biophysics, Chinese Academy of Sciences,                

      Regulated Cargo Binding studies on C-portion of ACAP1 protein in endocytic recycling

2004.9 – 2007.7, Graduate student, Tsinghua University,

 Crystallization and preliminary crystallographic analysis of cytochrome P450s.  

Research Projects：

National key research and development program  2021YFA1301500       2021/12 – 2026/11  

Role: Key member

Advanced technology for structural analysis of large protein machines

NSFC   31670744   2018/01-2021/12   Role:PI

Molecular mechanism studies on membrane remodeling by two protein families in intracellular transport pathway

973 Project   2014CB910700   2014.01--2018.08   Role: Key member

High resolution 3D reconstruction and function studies on complicated macro-molecules by Cry0-EM

NSFC   31000635   2011.01-2013.12   Role:PI

Structural and functional studies of adaptor ACAP1 in recycling pathway

Selected Publications:

Y. Zhang#, X. Pang#*, J. Li, J. Xu, V. W. Hsu*, and F. Sun*.Structural insights into membrane remodeling by SNX1. Proc Natl Acad Sci U S A. 2021Vol. 118 No. 10 e2022614118. (#: Co-first author, *:Co-corresponding author)

Zhang D., Zhang Y., Ma J., Zhu C., Niu T., Chen W., Pang X., Zhai Y.,and Sun F.* (2020) Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding. eLife 9: e50294. doi:10.7554/eLife.50294

Zhu G., Zeng H., Zhang S., Juli J., Pang X., Hoffmann J., Zhang Y., Morgner N., Zhu Y.*, Peng G.*, Michel H.* and Sun F.* (2020) A 3.3 A-resolution structure of hyperthermophilic respiratory complex III reveals the mechanism of its thermal stability. Angew Chem Int Ed Engl. 59 (1): 343-351. doi: 10.1002/anie.201911554.

Chan, C. ^#, X. Pang^#, Y. Zhang, T. Niu, S. Yang, D. Zhao, J. Li, L. Lu, V.W. Hsu, J. Zhou*, F. Sun*, and J. Fan*. 2019. ACAP1 assembles into an unusual protein lattice for membrane deformation through multiple stages. Plos Comput Biol. 15:e1007081. (#: Co-first author).

Ma, J., Zhai, Y., Chen, M., Zhang, K., Chen, Q., Pang, X.* , and Sun, F.* (2019). New interfaces on MiD51for Drp1 recruitment and regulation. PloS one 14 , e0211459. (*: Co-corresponding author)

Wang S., Zhai Y., Pang X., Niu T., Ding Y.H., Dong, M.Q., Hsu W.V. Sun Z.* and Sun F.* (2016), Structural characterization of coatomer in its cytosolic state. Proten Cell 7(8): 586-600

Sun F. ^#, Pang X. ^#, Xie T., Zhai Y., Wang G.G. and Sun F.  (2015), BrkAutoDisplay: functional display of multiple exogenous proteins on the surface of Escherichia coli by using BrkA autotransporter. Microbial Cell Factories. 14: 129. (#:Co-first author)

Pang X., Fan J., Zhang Y., Zhang K., Gao B., Ma J., Li J., Deng Y., Zhou Q., Egelman E.H., Hsu V.W. and Sun F. (2014), A PH Domain in ACAP1 Possesses Key Features of the BAR Domain in Promoting Membrane Curvature. Developmental Cell, 31(1) : 73-86.

Zhou Q., Li J., Yu H., Zhai Y., Gao Z., Liu Y., Pang X., Zhang L., Schulten K., Sun F. and Chen C. (2014), Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. Nature Communications, 5:3552

Sun F., Zhou Q., Pang X., Xu Y. and Rao Z. (2013), Revealing various coupling of electron transfer and proton pumping in mitochondrial respiratory chain. Current Opinion in Structural Biology, 23: 526-538

Bai M.^#, Pang X. ^#, Lou J., Zhou Q., Zhang K., Ma J., Li J., Sun F. Hsu V. (2012), Mechanistic insights into regulated cargo binding by ACAP1.  Journal of Biological Chemistry, 287: 28675-28685. (#:Co-first author).

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