The romance of replication: Hand in hand, from dawn to dusk
Runze Ma, Zijing Liu, Bing Zhu
Abstract
Faithful DNA duplication is the fundamental event for all life forms. How to replicate the whole genome quickly and efficiently is a challenge that must be faced within every S phase of the cell cycle. Considering the increased size and complexity of mammalian genomes, it is plausible that the regulation of DNA replication is more intricate in mammals. Tens of thousands of replication origins have been identified throughout mammalian genomes. Whether replication forks originated from different origins cooperate during replication is a long-term concern in the field.
附件下载：
The romance of replication: Hand in hand, from dawn to dusk, Sci Bull, 24 Jun 2024
Science Bulletin, 24 June, 2024, DOI：https://doi.org/10.1016/j.scib.2024.06.028
The romance of replication: Hand in hand, from dawn to dusk
Runze Ma, Zijing Liu, Bing Zhu
Abstract
Faithful DNA duplication is the fundamental event for all life forms. How to replicate the whole genome quickly and efficiently is a challenge that must be faced within every S phase of the cell cycle. Considering the increased size and complexity of mammalian genomes, it is plausible that the regulation of DNA replication is more intricate in mammals. Tens of thousands of replication origins have been identified throughout mammalian genomes. Whether replication forks originated from different origins cooperate during replication is a long-term concern in the field.
文章链接：https://www.sciencedirect.com/science/article/pii/S2095927324004535?via%3Dihub