How do metabolic stresses trigger catabolic autophagy for cell survival? A study now reveals that the metabolite sensor Pho81 integrates into and activates the kinase activity of the Atg1 complex for pexophagy triggered by phosphate starvation. This demonstrates the plasticity of the autophagy-initiating Atg1 complex.
附件下载：
Compositional plasticity of the Atg1 complex, Nat Cell Biol, 5 Feb 2024
Nature Cell Biology, 5 February, 2024, DOI：https://doi.org/10.1038/s41556-023-01340-4
Compositional plasticity of the Atg1 complex
Xiaoli Ma & Hong Zhang
Abstract
How do metabolic stresses trigger catabolic autophagy for cell survival? A study now reveals that the metabolite sensor Pho81 integrates into and activates the kinase activity of the Atg1 complex for pexophagy triggered by phosphate starvation. This demonstrates the plasticity of the autophagy-initiating Atg1 complex.
文章链接：https://www.nature.com/articles/s41556-023-01340-4