Tumor-associated myeloid cells (TAMCs) are the predominant immune population in glioblastoma (GBM), but the definite role of TAMCs in GBM tumorigenicity remains uncertain. In this issue of Cell Metabolism, Rashidi et al. identify a specific population of TAMCs surrounding hypoxic regions of GBM. These TAMCs provide creatine to nearby tumor cells to promote GBM progression.
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TAMC-derived creatine sustains glioblastoma growth, Cell Metab, 2 Jan 2024
Cell Metabolism, 2 January, 2024, DOI：https://doi.org/10.1016/j.cmet.2023.12.012
TAMC-derived creatine sustains glioblastoma growth
Huiwen Yan, Pengcheng Bu
Abstract
Tumor-associated myeloid cells (TAMCs) are the predominant immune population in glioblastoma (GBM), but the definite role of TAMCs in GBM tumorigenicity remains uncertain. In this issue of Cell Metabolism, Rashidi et al. identify a specific population of TAMCs surrounding hypoxic regions of GBM. These TAMCs provide creatine to nearby tumor cells to promote GBM progression.
文章链接：https://www.sciencedirect.com/science/article/pii/S1550413123004631?via%3Dihub