TiO2 supported single Ag atoms nanozyme for elimination of SARS-CoV2
Daji Wang, Bin Zhang, Hui Ding, Dan Liu, Jianquan Xiang, Xuejiao J.Gao, Xuehui Chen, Zhongjun Li, Lei Yang, Hongxia Duan, Jiyan Zheng, Zheng Liu, Bing Jiang, Yang Liu, Ni Xie, Han Zhang, Xiyun Yan, Kelong Fan, Guohui Nie
Abstract
The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO2 supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO2 SAN) is designed to serve as a highly efficient antiviral nanomaterial. Compared with traditional nano-TiO2 and Ag, Ag-TiO2 SAN exhibits higher adsorption (99.65%) of SARS-CoV2 pseudovirus. This adsorption ability is due to the interaction between SAN and receptor binding domain (RBD) of spike 1 protein of SARS-CoV2. Theoretical calculation and experimental evidences indicate that the Ag atoms of SAN strongly bind to cysteine and asparagine, which are the most abundant amino acids on the surface of spike 1 RBD. After binding to the virus, the SAN/virus complex is typically phagocytosed by macrophages and colocalized with lysosomes. Interestingly, Ag-TiO2 SAN possesses high peroxidase-like activity responsible for reactive oxygen species production under acid conditions. The highly acidic microenvironment of lysosomes could favor oxygen reduction reaction process to eliminate the virus. With hACE2 transgenic mice, Ag-TiO2 SAN showed efficient anti-SARS-CoV2 pseudovirus activity. In conclusion, Ag-TiO2 SAN is a promising nanomaterial to achieve effective antiviral effects for SARS-CoV2.
附件下载：
TiO2 supported single Ag atoms nanozyme for elimination of SARS-CoV2, Nano Today, 7 Jul 2021
Nano Today, 7 July, 2021, DOI：https://doi.org/10.1016/j.nantod.2021.101243
TiO2 supported single Ag atoms nanozyme for elimination of SARS-CoV2
Daji Wang, Bin Zhang, Hui Ding, Dan Liu, Jianquan Xiang, Xuejiao J.Gao, Xuehui Chen, Zhongjun Li, Lei Yang, Hongxia Duan, Jiyan Zheng, Zheng Liu, Bing Jiang, Yang Liu, Ni Xie, Han Zhang, Xiyun Yan, Kelong Fan, Guohui Nie
Abstract
The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO2 supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO2 SAN) is designed to serve as a highly efficient antiviral nanomaterial. Compared with traditional nano-TiO2 and Ag, Ag-TiO2 SAN exhibits higher adsorption (99.65%) of SARS-CoV2 pseudovirus. This adsorption ability is due to the interaction between SAN and receptor binding domain (RBD) of spike 1 protein of SARS-CoV2. Theoretical calculation and experimental evidences indicate that the Ag atoms of SAN strongly bind to cysteine and asparagine, which are the most abundant amino acids on the surface of spike 1 RBD. After binding to the virus, the SAN/virus complex is typically phagocytosed by macrophages and colocalized with lysosomes. Interestingly, Ag-TiO2 SAN possesses high peroxidase-like activity responsible for reactive oxygen species production under acid conditions. The highly acidic microenvironment of lysosomes could favor oxygen reduction reaction process to eliminate the virus. With hACE2 transgenic mice, Ag-TiO2 SAN showed efficient anti-SARS-CoV2 pseudovirus activity. In conclusion, Ag-TiO2 SAN is a promising nanomaterial to achieve effective antiviral effects for SARS-CoV2.
文章链接：https://www.sciencedirect.com/science/article/pii/S1748013221001687?via%3Dihub#!