当前位置:  首页 >> 最新重要论文

最新重要论文

Structures and Functions of Chromatin Fibers, Annu Rev Biophys, May 2021

发布时间:2021年05月31日

Annual Review Of Biophysics, May, 2021, DOI:https://doi.org/10.1146/annurev-biophys-062920-063639

Structures and Functions of Chromatin Fibers

Ping Chen, Wei Li and Guohong Li

Abstract

In eukaryotes, genomic DNA is packaged into chromatin in the nucleus. The accessibility of DNA is dependent on the chromatin structure and dynamics, which essentially control DNA-related processes, including transcription, DNA replication, and repair. All of the factors that affect the structure and dynamics of nucleosomes, the nucleosome–nucleosome interaction interfaces, and the binding of linker histones or other chromatin-binding proteins need to be considered to understand the organization and function of chromatin fibers. In this review, we provide a summary of recent progress on the structure of chromatin fibers in vitro and in the nucleus, highlight studies on the dynamic regulation of chromatin fibers, and discuss their related biological functions and abnormal organization in diseases.

文章链接:https://www.annualreviews.org/doi/10.1146/annurev-biophys-062920-063639

 

 

    附件下载: