Nature Communications, 11 November, 2023, DOI：https://doi.org/10.1038/s41467-023-43176-4
Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus
Beibei Li, Ruonan Ma, Lei Chen, Caiyu Zhou, Yu-Xiao Zhang, Xiaonan Wang, Helai Huang, Qikun Hu, Xiaobo Zheng, Jiarui Yang, Mengjuan Shao, Pengfei Hao, Yanfen Wu, Yizhen Che, Chang Li, Tao Qin, Lizeng Gao, Zhiqiang Niu & Yadong Li
Abstract
Enveloped viruses encased within a lipid bilayer membrane are highly contagious and can cause many infectious diseases like influenza and COVID-19, thus calling for effective prevention and inactivation strategies. Here, we develop a diatomic iron nanozyme with lipoxidase-like (LOX-like) activity for the inactivation of enveloped virus. The diatomic iron sites can destruct the viral envelope via lipid peroxidation, thus displaying non-specific virucidal property. In contrast, natural LOX exhibits low antiviral performance, manifesting the advantage of nanozyme over the natural enzyme. Theoretical studies suggest that the Fe-O-Fe motif can match well the energy levels of Fe2 minority β-spin d orbitals and pentadiene moiety π* orbitals, and thus significantly lower the activation barrier of cis,cis-1,4-pentadiene moiety in the vesicle membrane. We showcase that the diatomic iron nanozyme can be incorporated into air purifier to disinfect airborne flu virus. The present strategy promises a future application in comprehensive biosecurity control.
文章链接：https://www.nature.com/articles/s41467-023-43176-4
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