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Nanozyme: Discovery and its applications in tumor diagnosis and therapy
CD146: Discovery and its applications in tumor immunotherapy
Publications
2019
l Xi Hu, Fangyuan Li, Fan Xia, Xia Guo, Nan Wang, Lili Liang, Bo Yang, Kelong Fan, Xiyun Yan, and Daishun Ling. Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy. J Am Chem Soc. 2019 Dec 27.
l Ruofei Zhang, Yunlong Zhou, Xiyun Yan*, Kelong Fan*. Advances in chiral nanozymes: a review. Mikrochim Acta. 2019 Nov 15;186(12):782.
l Xiangqin Meng, Iman Zare, Xiyun Yan*, Kelong Fan*. Protein-protected metal nanoclusters: An emerging ultra-small nanozyme. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Nov 14:e1602.
l Lizeng Gao, Xiyun Yan. Nanozymes: Biomedical Applications of Enzymatic Fe3O4 Nanoparticles from In Vitro to In Vivo. Adv Exp Med Biol. 2019;1174:291-312.
l Xiangqin Meng, Kelong Fan*, Xiyun Yan*. Nanozymes: an emerging field bridging nanotechnology and enzymology. Sci China Life Sci. 2019 Nov;62(11):1543-1546.
l Shuai Zhao, Hongxia Duan, Yili Yang, Xiyun Yan* and Kelong Fan*. Fenozyme Protects the Integrity of the Blood-Brain Barrier against Experimental Cerebral Malaria. Nano Lett. 2019 Dec 11;19(12):8887-8895.
l Jiuyang He, Kelong Fan*, Xiyun Yan*. Ferritin drug carrier (FDC) for tumor targeting therapy. J Control Release. 2019 Sep 5.
l Yongting Luo, Xiao Teng, Lingling Zhang, Jianan Chen, Zheng Liu, Xuehui Chen, Shuai Zhao, Sai Yang, Jing Feng* & Xiyun Yan*. Publisher Correction: CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension. Nat Commun. 2019 Aug 7;10(1):3551.
l Dawei Jiang, Dalong Ni, Zachary T. Rosenkrans, Peng Huang*, Xiyun Yan* and Weibo Cai*. Nanozyme: new horizons for responsive biomedical applications. Chem Soc Rev. 2019 Jul 15;48(14):3683-3704.
l Minmin Liang*, Xiyun Yan*. Nanozymes: From New Concepts, Mechanisms, and Standards to Applications. Acc Chem Res. 2019 Jul 5.
l Yiliang Jin, Jiuyang He, Kelong Fan*, Xiyun Yan*. Ferritin variants: inspirations for rationally designing protein nanocarriers. Nanoscale. 2019 Jul 14;11(26):12449-12459.
l Bing Jiang, Ruofei Zhang, Jianlin Zhang, Yaxin Hou, Xuehui Chen, Meng Zhou, Xiuyun Tian, Chunyi Hao, Kelong Fan*, Xiyun Yan*. GRP78-targeted ferritin nanocaged ultra-high dose of doxorubicin for hepatocellular carcinoma therapy. Theranostics. 2019, 9(8): 2167-2182.
l Bing Jiang#, Liang Yan#, Jianlin Zhang, Meng Zhou, Guizhi Shi, Xiuyun Tian, Kelong Fan*, Chunyi Hao*, and Xiyun Yan*. Biomineralization synthesis of cobalt nanozyme in SP94-ferritin for targeting and visualizing hepatocellular carcinoma tissues. ACS Appl. Mater. & interfaces. 2019, 11: 9747-9755.
l Bolong Xu#, Hui Wang#, Weiwei Wang#, Lizeng Gao, Shanshan Li, Xueting Pan, Hongyu Wang, Hailong Yang, Xiangqin Meng, Qiuwen Wu, Lirong Zheng, Shenming Chen, Xinghua Shi, Kelong Fan*, Xiyun Yan*, and Huiyu Liu*. Single-Atom Nanozyme for Wound Antibacterial Applications. Angewandte Chemie International Edition. 2019 Jan 29.
l Hui Ding, Yanjuan Cai, Lizeng Gao, Minmin Liang, Beiping Miao, Hanwei Wu, Yang Liu, Ni Xie, Aifa Tang, Kelong Fan*, Xiyun Yan*,and Guohui Nie*. Exosome-like Nanozyme Vesicles for H2O2-Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma. NANO LETTERS. 2019, 19, 203-209
2018
l Minmin Liang# , Hui Tan#, Jun Zhou, Tao Wang, Demin Duan, Kelong Fan , Jiuyang He, Dengfeng Cheng*, Hongcheng Shi*, Hak Soo Choi*, and Xiyun Yan*. Bioengineered H-Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosis. ACS Nano. 2018 Sep 25;12(9):9300-9308.
l Zhuobin Xu, Zhiyue Qiu, Qi Liu, Yixin Huang, Dandan Li, Xinggui Shen, Kelong Fan, Juqun Xi, Yunhao Gu, Yan Tang, Jing Jiang, Jialei Xu, Jinzhi He, Xingfa Gao, Yuan Liu, Hyun Koo, Xiyun Yan , Lizeng Gao*. Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections. Nat Commun. 2018 Sep 13;9(1):3713.
l Yang Du#, Kelong Fan#, Hejun Zhang#, Li Li, Peixia Wang, Jiuyang He, Shigang Ding*, Xiyun Yan*, Jie Tian*. Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle. Nanomedicine: NBM. 2018 Jul 26;14(7):2259-2270.
l Kelong Fan and Xiyun Yan. Chapter 6 - Bioengineered Ferritin Nanoprobes for Cancer Theranostics. in Handbook of Nanomaterials for Cancer Theranostics, J. Conde, Editor. 2018, Elsevier. p. 143-175.
l Bing Jiang, Demin Duan, Lizeng Gao, Mengjie Zhou, Kelong Fan, Yan Tang, Juqun Xi, Yuhai Bi, Zhou Tong, George Fu Gao, Ni Xie, Aifa Tang, Guohui Nie, Minmin Liang and Xiyun Yan. Standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes. Nat Protoc. 2018 Jul 2.
l Yanbin Ma, Haofeng Zhang, Chaoliang Xiong, Zheng Liu, Qingji Xu, Jing Feng, Jun Zhang, Zhaoqing Wang, Xiyun Yan. CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition. Cancer Lett. 2018 Aug 28;430:201-214.
l Lingling Zhang, Yongting Luo, Xiao Teng, Zhenzhen Wu, Mengtao Li, Dong Xu, Qian Wang, Fei Wang, Jing Feng&Xiaofeng Zeng&Xiyun Yan. CD146: a potential therapeutic target for systemic sclerosis. Protein Cell. 2018 Apr 18.
l Kelong Fan, Juqun Xi, Lei Fan, Peixia Wang, Chunhua Zhu, Yan Tang, Xiangdong Xu, Minmin Liang,Bing Jiang, Xiyun Yan&Lizeng Gao. In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy. Nat Commun. 2018 Apr 12;9(1):1440.
l Kelong Fan, Bing Jiang, Zhe Guan, Jiuyang He, Dongling Yang, Ni Xie, GuohuiNie, Can Xie, Xiyun Yan. Fenobody: A Ferritin-Displayed Nanobody with High Apparent Affinity and Half-Life Extension. Anal Chem.2018 Apr 10.
l Kelong Fan, Xiaohua Jia, Meng Zhou, Kun Wang, Joao Conde, Jiuyang He, Jie Tian, Xiyun Yan. Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma. ACS Nano. 2018 Apr 4.
2017
l Chen J, Luo Y, Huang H, Wu S, Feng J, Zhang J, Yan X.CD146 is essential for PDGFRβ-induced pericyte recruitment. Protein Cell. 2017 Oct 16.
l Kelong Fan, Meng Zhou, Xiyun Yan. Questions about horse spleen ferritin crossing the blood brain barrier via mouse transferrin receptor 1. Protein Cell. 2017 Oct 9.
l Lizeng Gao, Kelong Fan, Xiyun Yan. Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetic for Biomedical Applications. Theranostics. 2017; 7(13):3207-3227.
l Jianan Chen, Yongting Luo, Hui Hui, TanxiCai, Hongxin Huang, Fuquan Yang, Jing Feng, Jingjing Zhang, and Xiyun Yan. CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl AcadSci U S A. 2017 Aug 21.
l Huiwen Yan, Chunxia Zhang,Zhaoqing Wang,Tao Tu,Hongxia Duan, Yongting Luo, Jing Feng, Feng Liu, and Xiyun Yan. CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis. Scientific Reports. 2017 Aug 7;7(1):7442.
l Qian Gao, Junfeng Zhang, Xiumei Wang, Ying Liu, Rongqiao He, Xingfeng Liu, Fei Wang, Jing Feng, Dongling Yang, Zhaoqing Wang, AnmingMeng,and Xiyun Yan. The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Nature Communications. 2017 Jun 7;8:15279.
l Yongting Luo, HongxiaDuan, Yining Qian, Liqun Feng, Zhenzhen Wu, Fei Wang, Jing Feng, Dongling Yang, Zhihai Qin, Xiyun Yan. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Research. 2017 Mar;27(3):352-372.
2016
l Fan K, Wang H, Xi J, Liu Q, Meng X, Duan D, Gao L, Yan X. Optimization of Fe3O4 nanozyme activity via single amino acid modification mimicking an enzyme active site. Chem Commun (Camb). 2016 Dec 22;53(2):424-427.
l Dan Liu, Lei Du, Dong Chen, Zhongde Ye, Hongxia Duan, Tao Tu, Jing Feng, Yili Yang, Quan Chen, Xiyun Yan*. Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling. Oncotarget. 2016 Jun 9.
l Lizeng Gao , Xiyun Yan*. Nanozymes: an emerging field bridging nanotechnology and biology. Science China-Life Science. 2016 Apr;59(4):400-2.
l Yanzhao Zhao, Minmin Liang, Xiao Li, Kelong Fan, Jie Xiao, Yanli Li, Hongcheng Shi, Fei Wang, Hak Soo Choi,* Dengfeng Cheng,* and Xiyun Yan*. Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging. ACS Nano. 2016; 10 (4), 4184–4191
2015
l Demin Duan, Kelong Fan, Dexi Zhang, ShuguangTan, Mifang Liang, Yang Liu, Jianlin Zhang, PanheZhang, Wei Liu, Xiangguo Qiu, Gary P. Kobinger,George Fu Gao, Xiyun Yan* . Nanozyme-strip for rapid local diagnosis of Ebola. Biosensors and Bioelectronic. 2015;74(5),134-141.
l Tao Tu, Chunxia Zhang, Huiwen Yan, Yongting Luo, Ruirui Kong, Pushuai Wen, Zhongde Ye, Jianan Chen, Jing Feng, Feng Liu, Jane Y. Wu*, Xiyun Yan*. . CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Research. 2015;25(3), 275-87.
2014
l Yimin Qian,Yongting Luo, Hongxia Duan, Liqun Feng,Qi Bi, Yongjun Wang, Xiyun Yan*. Adhesion Molecule CD146 and its Soluble Form Correlate Well with Carotid Atherosclerosis and Plaque Instability. Cns Neuroscience & Therapeutics. 2014; 20,438-45.
l Minmin Liang, Kelong Fan, Meng Zhou, Demin Duan, Jiyan Zheng, Dongling Yang, Jing Fengand Xiyun Yan*. H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection. Proc Natl Acad Sci U S A. 2014;111(41) ,14900-5.
l Qiqun Zeng, Peng Zhang, Zhenzhen Wu, Peng Xue, Di Lu, Zhongde Ye, Xinlei Zhang, Zechi Huang, Jing Feng, Lina Song, Dongling Yang, Taijiao Jiang, Xiyun Yan*. Quantitative proteomics reveals ER-involvement in CD146-induced epithelial-mesenchymal transition in breast cancer cells. Journal of Proteomics, 2014; 103,153-69.
l Shu Xing, Yongting Luo, Zhihua Liu, Pengcheng Bu, Hongxia Duan, Dan Liu, Ping Wang, Jing Yang, Lina Song, Jing Feng, Dongling Yang, Zhihai Qin, Xiyun Yan*. Targeting endothelial CD146 attenuates colitis and prevents colitis associated carcinogenesis. The American Journal of Pathology. 2014;184(5),1604-16.
l Qiqun Zeng, Zhenzhen Wu, Hongxia Duan, Xuan Jiang, Tao Tu, Di Lu, Yongting Luo, Ping Wang, Lina Song, Jing Feng, Dongling Yang, Xiyun Yan*. Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice. Protein Cell. 2014; 5(6),445–456.
l Qian Gao, Xiongfei Chen, Hongxia Duan, Zhaoqing Wang, Jing Feng, Dongling Yang, Lina Song, Ningxin Zhou, and Xiyun Yan*. FXYD6: a novel therapeutic target toward hepatocellular carcinoma. Protein Cell. 2014;5(7),532-43.
2013
l Zhongde Ye, Chunxia Zhang, Tao Tu, Min Sun, Dan Liu, Di Lu, Jing Feng, Dongling Yang,Feng Liu*& Xiyun Yan*.Wnt5a uses CD146 as a receptor to regulatecell motility and convergent extension.Nature Communications. 2013;4,2803.
l Ping Wang, Yongting Luo, Hongxia Duan, Shu Xing, Jianlin Zhang, Di Lu, Jing Feng, Dongling Yang, Lina Song, Xiyun Yan*. MicroRNA 329 Suppresses Angiogenesis by Targeting CD146. Molecular and Cellular Biology. 2013;33(18),3689-99.
l Tao Tu, Qian Gao, Yongting Luo, Jianan Chen, Di Lu, Jing Feng, Dongling Yang, Lina Song, Xiyun Yan*.CD146 Deletion in the Nervous System Impairs Appetite,Locomotor Activity and Spatial Learning in Mice. PLoS ONE. 2013;8(9),e74124.
l Fei Wang, Xichong Yan, Lina Song, Ping Wang, Di Lu, Jing Feng, Dongling Yang, Xiyun Yan*. A novel 'pipeline' system for downstream preparation of therapeutic monoclonal antibodies. Biotechnology Letters. 2013; 35,1411-8.
l Hongxia Duan, Shu Xing, Yongting Luo, Liqun Feng, Irene Gramaglia, Ying Zhang, Di Lu, Qiqun Zeng, Kelong Fan, Jing Feng, Dongling Yang, Zhihai Qin, Pierre-Olivier Couraud, Ignacio A. Romero, Babette Weksler, Xiyun Yan*. Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS. Scientific Reports. 2013; 3,1687.
l Kelong Fan, Lizeng Gao, Xiyun Yan*. Human ferritin for tumor detection and therapy. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2013; 5(4), 287-98.
l Hongxia Duan, Yongting Luo, Hongjun Hao,Liqun Feng, Ying Zhang, Di Lu, Shu Xing, Jing Feng, Dongling Yang, Lina Song, Xiyun Yan*. Soluble CD146 in cerebrospinal fluid ofactive multiple sclerosis. Neuroscience. 2013; 235,16-26.
l Haofeng Zhang, Jun Zhang, Zhaoqing Wang, Di Lu, Jing Feng, Dongling Yang, Xiuqin Chen, Xiyun Yan*. CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer. Oncology Letters. 2013 Apr;5(4),1189-1194.
l Minmin Liang, Kelong Fan, Yong Pan, Hui Jiang, Fei Wang, Dongling Yang, Di Lu, Jing Feng, Jianjun Zhao, LiuYang, Xiyun Yan*. Fe3O4 magnetic nanoparticle peroxidase mimetic-based colorimetric assay for the rapid detection of organophosphorus pesticide and nerve agent. Analytical Chemistry. 2013; 85(1),308-12.
l Zhaoqing Wang, Xiyun Yan*. CD146, a multi-functional molecule beyond adhesion. Cancer Letters. 2013; 330(2),150-62.
l Yunhe An, Wei Han, Xiuqin Chen, Xiaohang Zhao, Di Lu, Jing Feng, Dongling Yang, Lina Song,Xiyun Yan*. A novel anti-sTn monoclonal antibody 3P9 inhibits human xenografted colorectal carcinomas.Journal of Immunotherapy. 2013;36(1),20-8.
l Demin Duan, Lixing Hui, Lishi Li, Xiyun Yan*, Jiong Li*. Establishment and Optimization of a Label free microRNA Microarray Analytical Method. Progress in Biochemistry and Biophysics. 2013;40(5),479-89.
2012
l Kelong Fan, Changqian Cao, Yongxin Pan, Di Lu, Dongling Yang, Jing Feng,Lina Song, Minmin Liang & Xiyun Yan*. Magnetoferritin nanoparticles for targeting and visualizing tumor tissues. Nature Nanotechnology. 2012; 7(7),459-64.
(Highlighted by commentary articles in GEN 2012,6)
l Tianxia Jiang, Jie Zhuang, Hongxia Duan, Yongting Luo, Qiqun Zeng, Kelong Fan, Huiwen Yan, Di Lu, Zhongde Ye, Junfeng Hao, Jing Feng, Dongling Yang, Xiyun Yan*. CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. Blood. 2012; 120(11),2330-9.
(Highlighted by commentary articles in Blood 2012,9,(120)2164-2165)
l Qiqun Zeng, Weidong Li, Di Lu, Zhenzhen Wu, Hongxia Duan, Yongting Luo, Jing Feng, Dongling Yang, Li Fu, and Xiyun Yan*. CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(4),1127-32.
l Yongting Luo, Chaogu Zheng, Jinbin Zhang, Di Lu, Jie Zhuang, Shu Xing, Jing Feng, Dongling Yang, Xiyun Yan*. Recognition of CD146 as an ERM-binding protein offers novel mechanisms for melanoma cell migration. Oncogene. 2012;31(3),306-21.
l Jie Zhuang,Kelong Fan,Lizeng Gao,Di Lu,Jing Feng,Dongling Yang,Ning Gu, Yu Zhang, Minmin Liang and Xiyun Yan*. Ex Vivo Detection of iron oxide magnetic nanoparticles in mice using their intrinsic peroxidase-mimicking activity. Molecular Pharmaceutics. 2012;9(7),1983-9.
l Yunhe An, Haofeng Zhang, Min Sun, Jun Zhang, Xiuqin Chen, Dong Chen, Di Lu, Jing Feng, Dongling Yang, Lina Song, Xiyun Yan*.sTn is a novel biomarker for type endometrial carcinoma. Progress in Biochemistry and Biophysics. 2012; 39(6),548-55.
2011
l Chaogu Zheng, Jing Feng, Di Lu, Ping Wang, Shu Xing, Jean-Luc Coll, Dongling Yang,Xiyun Yan*. A novel anti-CEACAM5 monoclonal antibody, CC4, suppresses colorectal tumor growth and enhances NK cells-mediated tumor immunity. PLoS ONE. 2011;6(6),e21146.
l Demin Duan, Kexiao Zheng, Ye Shen, Rong Cao, Li Jiang, Zhuoxuan Lu,Xiyun Yan and Jiong Li*. Label-free high-throughput microRNA expressionprofiling from total RNA. Nucleic Acids Research. 2011; 39(22), e154.
l Weidong Li, Dongling Yang, Shuling Wang, Xiaojing Guo, Ronggang Lang, Yu Fan, Feng Gu,Xinmin Zhang, Yun Niu, Xiyun Yan*, Li Fu*. Increased expression of CD146 and microvessel density (MVD) in invasivemicropapillary carcinoma of the breast: Comparative study with invasive ductalcarcinoma-not otherwise specified. PathologyResearch and Practice. 2011; 207(12),739-46.
l Yu Niu, Jie Zhuang, Li Liu, Xiyun Yan, Gang Jin*. Two kinds of anti-ricin antibody and ricin interaction evaluated by biosensor basedon imaging ellipsometry. Thin Solid Films. 2011; 519(9),2768-2771.
2010
l Xinglu Huang, Jie Zhuang, Xu Teng,Linlin Li, Dong Chen, Xiyun Yan, Fangqiong Tang*. The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species. Biomaterial, 2010; 31(24), 6142-6153.
l Bin Mu, Xinglu Huang, Pengcheng Bu, Jie Zhuang, Zhixue Cheng, Jing Feng,Dongling Yang,Changsheng Dong, Jianbing Zhang, Xiyun Yan*. Influenza virusdetectionwithpentabody-activatednanoparticles. Journal ofVirologicalMethods. 2010;169,282-289.
l Jie Zhuang, Tianxia Jiang, Di Lu, Yongting Luo, Chaogu Zheng, Jing Feng, Dongling Yang, Chang Chen, Xiyun Yan*. NADPH oxidase4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction. Free Radical Biology & Medicine. 2010; 49,227-236.
l Jie Zhuang, Tao Cheng, Lizeng Gao, Yongting Luo, Quan Ren, Di Lu,Fangqiong Tang, Xiangling Ren, Dongling Yang, Jing Feng, Jingdong Zhu, Xiyun Yan*. Silica coating magnetic nanoparticle-based silver enhancement immunoassay for rapid electrical detection of ricin toxin. Toxicon. 2010; 55(1), 145-52.
2009
l Bairu Zhang, Ling Li, Ying Zhang, Xiaofeng Zeng, Liqun Feng, Jing Feng, Dongling Yang, Chaogu Zheng, Xiyun Yan*. Elevated levels of soluble and neutrophil CD146 in active systemic vasculitis. Labmedicine. 2009; 40 (6),351-356.
l Xinglu Huang, Jie Zhuang, DongChen, Huiyu Liu, Fangqiong Tang*, Xiyun Yan, Xianwei Meng, Lin Zhang, Jun Ren. General strategy for designing functionalized magnetic microspheres for different bioapplications. Langmuir. 2009;25(19),11657-63.
l Chaogu Zheng, Yijun Qiu, Qiqun Zeng, Ying Zhang, Di Lu, Dongling Yang,Jing Feng, Xiyun Yan*. Endothelial CD146 is required for in vitro tumor-induced angiogenesis:The role of a disulfide bond in signaling and dimerization. The International Journal of Biochemistry and Cell Biology. 2009; 41(11), 2163-72.
l Cai Qi, Yi Lin, Jing Feng, Zhanhui Wang, Chuanfeng Zhu, Yonghong Meng, Xiyun Yan, Lijun Wan, Gang Jin*. Phage M13KO7 detection with biosensor based on imaging ellipsometryand AFM microscopic confirmation. Virus Research. 2009; 140(1-2),79-84.
2008
l Changcheng Yin, Lili Ren, Linlin Zhu, Xiangbin Wang, Zhong Zhang,Hualiang Huang, Xiyun Yan*. Construction of a fully synthetic human scFv antibody librarywith CDR3 regions randomized by a split–mix–split method and its application. The Journal of Biochemistry. 2008;144,591-8 .
l Shufen Wang, Yi Shen, Xiaohua Yuan, Kai Chen, Xiangyu Guo, Yongchang Chen, Yuyu Niu, Jian Li, Renhe Xu, Xiyun Yan*, Qi Zhou*, Weizhi Ji*. Dissecting signaling pathways that govern self-renewal of rabbit embryonic stem cells. The Journal of Biological Chemistry. 2008;283 (51),35929-40.
l Ying Zhang, Chaogu Zheng, Jinbin Zhang, Dongling Yang, Jing Feng, Di Lu, Xiyun Yan*. Generation and Characterization of a panel of monoclonal antibodies against distinctepitopes of human CD146. Hybridoma. 2008;27(5),345-52.
l Jie Zhuang, Jinbin Zhang, Lizeng Gao, Yu Zhang, Ning Gu, Jing Feng, Dongling Yang, Xiyun Yan*. A novel application of iron oxide nanoparticles for detection of hydrogenperoxide in acid rain. Materials Letters. 2008;62,3972-4.
l Jinbin Zhang, Jie Zhuang, Lizeng Gao, Yu Zhang, Ning Gu, Jing Feng, Dongling Yang, Xiyun Yan*. Decomposing phenol by the hidden talent of ferromagnetic nanoparticles. Chemosphere.2008;73(9),1524-8.
l Shuyan Zhang, Chaogu Zheng, Xiyun Yan, Weixi Tian*. Low concentration of condensed tannins from catechu significantly inhibitsfatty acid synthase and growth of MCF-7 cells. Biochemical and Biophysical Research Communications. 2008;371(4),654-8.
l Chaogu Zheng, Xiyun Yan*. Progress in epigenetic regulation of V(D)J recombination. Progress in Biochemistry and Biophysics. 2008; 35(2),133-42.
l Qin Liu, Bairu Zhang, Xingang Zhao, Ying Zhang,Yixun Liu, Xiyun Yan*. Blockade of adhesionmolecule CD146 causes pregnancy failure in mice. Journal of Cellular Physiology. 2008; 215(3),621-6.
l Leyu Wang, Peng Li, Jie Zhuang, Feng Bai, Jing Feng, Xiyun Yan, Yadong Li*. Carboxylic acid enriched nanospheres of semiconductor nanorods for cell imaging. Angewandte Chemie International Edition. 2008; 47(6),1054-7.
2007
l Lizeng Gao, Jie Zhuang, Leng Nie, Jinbin Zhang, Yu Zhang, Ning Gu, Taihong Wang, Jing Feng, Dongling Yang, Sarah Perrett, Xiyun Yan*. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nature Nanotechnology. 2007; 2 (9) ,577-83.
(Highlighted by commentary articles in Nature Nanotechnology 2007,(2),535-36; Science News 2007,11(172),174; Nature China 2007,8; Chem Soc Rev 2012,41,2122-34)
l Yun Lin, Xiaoping Wu, Yi Shen, Pengcheng Bu, Dongling Yang, Xiyun Yan*. A novel antibody AA98 VH/L directed against CD146 efficiently inhibits angiogenesis. Anticancer Research. 2007; 27 (6B),4219-24.
l Pengcheng Bu, Jie Zhuang, Jing Feng, Dongling Yang, Xun Shen, Xiyun Yan*. Visualization of CD146 dimerization and its regulation in living cells. Biochimica et Biophysica Acta (BBA) -Molecular Cell Research. 2007; 1773 (4) ,513-20.
l Leng Nie, Lizeng Gao, Xiyun Yan, Taihong Wang*. Functionalized tetrapod-like ZnO nanostructrures for DNA gene delivery. Solid State Phenomena. 2007; 121,747-50.
2006
l Xiyun Yan*. Angiogenesis-A novel therapeutic target. Journal of Medical Molecular Biology. 2006; 3(5), 323-30.
l Cai Qi, Jinzhu Duan, Zhanhui Wang, Yanyan Chen, Panhe Zhang, Lin Zhan, Xiyun Yan, Wuchun Cao, Gang Jin*. Investigation of interaction between two neutralizing monoclonal antibodies and SARS virus using biosensor based on imaging ellipsometry. Biomed Microdevices. 2006; 8(3), 247-53.
l Leng Nie, Lizeng Gao, Ping Feng, Jingyuan Zhang, Xingqiu Fu, Yonggang Liu, Xiyun Yan, Taihong Wang*. Three-Dimensional Functionalized Tetrapodlike ZnO Nanostructures for Plasmid DNA Delivery. Small. 2006; 2(5), 621-5.
l Pengcheng Bu, Lizeng Gao, Jie Zhuang, Jing Feng, Dongling Yang, Xiyun Yan*. Anti-CD146 monoclonal antibody AA98 inhibits angiogenesis via suppression of nuclear factor-kB activation . Molecular Cancer Therapeutics. 2006; 5(11), 2872-8.
l Lizeng Gao, Leng Nie, Taihong Wang, Yujun Qin, Zhixin Guo, Dongling Yang,Xiyun Yan*. Carbon nanotubes delivery of the GFP-geneinto mammalian cells. ChemBioChem. 2006; 7 (2) , 239- 42.
l Jinzhu Duan, Xin Ji, Jing Feng, Wei Han, Panhe Zhang, Wuchun Cao, Xueming Guo, Cai Qi, Dongling Yang, Gang Jin, Guangxia Gao,Xiyun Yan*. A human neutralizing antibody against a conformational epitope shared by oligomeric SARS S1 protein. Antiviral therapy. 2006; 11(1), 117-23.
l Yanyong Kang, Fengcai Wang, Jing Feng, Dongling Yang, Xu Yang, Xiyun Yan*. Knockdown of CD146 reduces the migration and proliferation of human endothelial cells. Cell Research. 2006; 16(3), 313-8.
l Yun Lin, Jing Feng, Dongling Yang, Yi Shen, Xiyun Yan*. Suppression of Human Hepatoma Growth In Vivo by a Monoclonal Antibody against a Mr 45,000 Protein. Cancer Investigation. 2006; 24(8), 734-9.
l Jing Feng, Yi Shen, DongLing Yang, Xiyun Yan*.A novel monoclonal antibody with a mono-specificity for a 46 kD-cytokeratin. Progress in Biochemistry and Biophysics. 2006; 33 (1) , 24-30.
2005
l Jinzhu Duan, Xiyun Yan*,Xueming Guo, Wuchun Cao, Wei Han, Cai Qi, Jing Feng, Dongling Yang,Guangxia Gao, Gang Jin. A human SARS-CoV neutralizing antibody against epitope on S2 protein. Biochemical Biophysical Research Communication. 2005; 333(1), 186-93.
2004
l Yun Lin, Xiyun Yan*, Wuchun Cao, Chaoying Wang, Jing Feng, Jinzhu Duan, Sishen Xie. Probing the Structure of the SARS Coronavirus Using Scanning Electron Microscopy. Antiviral Therapy. 2004; 9(2), 287-289.
l Qin Liu, Xiyun Yan*, Yang Li, Ying Zhang, Xingang Zhao, Yi Shen.Pre-eclampsia is associated with the failure of melanoma cell adhesion molecule (MCAM/CD146) expression by intermediate trophoblast. Lab Investigation. 2004; 84, 221-228.
l Andrea Bernini, Ottavia Spiga, Arianna Ciutti, Stefano Chiellini, Luisa Bracci, Xiyun Yan, Bojian Zheng, Jiandong Huang, Mingliang He, Huaidong Song, Pei Hao, Guoping Zhao, Neri Niccolai*. Prediction of quaternary assembly of SARS coronavirus peplomer. Biomolecular Structure Research Center & D BBCR. 2004; 325, 1210-4.
2003
l Xiyun Yan*, Yun Lin, Dongling Yang, Yi Shen, Mei Yuan, Zhiqiang Zhang, Peiyu Li, Hongtian Xia, Li Li, Dandan Luo, Qin Liu,Karlheinz Mann, Bernhard L Bader. A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth. Blood. 2003; 102 (1), 184-91.
(Highlighted by commentary articles in Faculty of 1000 Biology 2007(12).)
Xl Xiufang Xu, Yi Shen, Jing Wang, Feili Gong, Xiyun Yan*. Immuno-detection of exfoliated cells in sputum with a monoclonal antibody. The Chinese-German Journal of Clinical Oncology. 2003; 2(2), 110-3.
Prior to 2003
l Fang Fang, Lin Wang, Xiaojie Qi, Xiyun Yan, Lan Ding*, Daqing Zhao, Jiazuan Ni*. Human catalytic antibodies with glutathione peroxidase activity. Journal of Inorganic Biochemistry. 2001; 85 (4), 301-7.
l Li Guo,Jinhua Wang,Xiyun Yan, Runsheng Chen, Shijun Qian*, Guangzhen Meng. Characterization of L-asparaginase fused with a protective ScFv and stabilization mechanism. Biochemical and Biophysical Research Communications. 2000; 276(1), 197- 203.
l Li Guo,Jinhua Wang,Shijun Qian,Xiyun Yan,Runsheng Chen,Guangzhen Meng*. Construction and Structural Modeling of a Single-Chain Fv-Asparaginase Fusion Protein Resistant to Proteolysis. Biotechnology and bioengineering. 2000; 70(4), 456-63.
l Xiyun Yan*, Jian Tang,Xiaoping Wu, Fengcai Wang, Jiansheng Li, Dongling Yang. Human single chain antibody to vascular endothelial growth factor: gene cloning, high-level expression, affinity maturation and bioactivity. SCIENCE IN CHINA(Series C). 2000; 43(3), 232-238.
l Li Guo, Xiyun Yan, Shijun Qian*, Guangzhen Meng. Selecting and expressing protective single-chain fv fragment to stabilize L-asparaginase against inactivation by trypsin. Bio-technology and Applied Biochemistry. 2000; (31), 21-27.
l Peiyu Li, Mei Yuan, Xiyun Yan*. Anti-tumor effect of an Anti-endothelial cell monoclonal antibody on solid tumor xenograft in nude mice. Chinese Journal of Cancer Research. 1999; 11(2), 92.
l Xiyun Yan*, Xiaoping Wu,Li Li. A human single-chain Fv target to an antigen on stimulated human umbilical vein endothelial cells. Proceedings of the American Association for Cancer Research. 1999; 40, 558.
l Xiyun Yan*, Jian Tang, Xiaoping Wu. A human single-chain Fv to vascular endothelial growth factor. Proceedings of the American Association for Cancer Research. 1999; 40, 70.
l Jian Tang, Xiyun Yan*, Yuanyi Liu, Huasong Tian, Po Tian. Production and characterization of a human single-chain Fv to collagenase IV. Science in China (Series C). 1998; 41(4), 387-92.
l Yanxing Yu, Mei Yuan, Li Li,Xiyun Yan*. Expression and characterization of a recombinant IL2-single chain antibody fusion protein in E.Coli. High Technology letters. 1997; 3(1), 101-5.
l Xiyun Yan*, Po Tian. Human antibodies from a single-chain Fv fusion phage library. Chinese Science Bulletin. 1997; 42(15), 1300-3.
l Mei Yuan, Li Li, Xiyun Yan*. Gene cloning, expression and immunoreactivity of a single chain Fv-fragment antibody PS-9. High Technology Letters. 1996; 2, 99-102.
l Xiyun Yan*, Stephen V.Evans, Marcin J. Kaminke, Stephen D.Gillies, Ralph A.Reisfeld, Alan N. Houghton, Paul B. Chapman. Characterization of an Ig VH idiotope that results in specific homophilic binding and increased avidity for antigen. Journal of Immunology. 1996; 157(4), 1582-8.
l Xiyun Yan*, KuhnS,Traub P. A complex of intermediate filament protein-DNA: A target for autoantibodies in systemic lupus erythematosus. Journal of Chinese Medical Sciences. 1995; 10(2), 90-92.
l Xiyun Yan*, Li Li, Mei Yuan, Po Tian. Cloning, expression and characterization of a single-chain antibody PS-9 targeted to pancreatic cancer. Science in China, Series B. 1995; 38(10), 1230-6.
l Xiyun Yan*. A new method for purification of anti-DNA antibodies. Journal of Chinese Medical Sciences. 1994; 9(1), 208-10.
