Future trends in Protein Science include using peptide and protein construction motifs not only to produce new nanomaterials but also to fabricate novel devices and tools that cannot even be imagined a decade ago. Protein Science has generally been associated with protein purifications, biophysical characterization of proteins, CD, NMR and X-ray structural determinations of proteins, drug target of proteins, protomics and high throughput structural genomics. That is about to change. Protein science will also expand to discovery and fabrication of biological and molecular materials with diverse structures, functionalities and utilities. Advent of nanobiotechnology and nanotechnology accelerated this trend. Similar as construction of an intricate architectural structure, diverse and numerous structural motifs are used to assemble a sophisticated complex. Nature has selected, produced and evolved numerous protein molecular architectural motifs over billions of years for particular functions. These protein molecular motifs can now be used to build materials from the bottom up. Protein Science will continue to harness proteins enormous power to benefit other disciplines and society.