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南开大学联合实验室

黄兴禄  博士 教授 博士生导师  

南开大学生命科学学院、药物化学生物学国家重点实验室、生物活性材料教育部重点实验室
中科院生物物理所客座研究员

研究方向:纳米酶新技术的开发与应用

电子邮件:huangxinglu@nankai.edu.cn

电       话:

通讯地址:天津市南开区卫津路94号南开大学分子所410

英文版个人网页:

简       历:

  2007 - 2010  中国科学院理化技术研究所,博士

  2010 - 2014  美国国立卫生研究院,博士后

  2014 - 2017  约翰霍普金斯大学,博士后

  2018 - 至今  南开大学

获奖及荣誉:

社会任职:

 

研究方向:

  至目前为止已发表SCI研究论文共计40余篇,论文他人引用累计近4000次,H-index为30。以第一/通讯作者发表论文20余篇,包括Science AdvPNASNature ProtocJACSAngew ChemieACS NanoBiomaterials等。目前研究方向主要以合成生物学理念,发展新一代纳米技术,代表性技术主要包括纳米酶和纳米化人造细胞,用于肿瘤诊疗、组织修复与再生等方面的研究工作。

承担项目情况:

代表论著:

  1. Zhang R, Luo W, Zhang Y, Zhu D, Midgley AC, Song H, Khalique A, Zhang H, Zhuang J, Kong D*, Huang X*. Particle-based Artificial Three-dimensional Stem Cell Spheroids for Revascularization of Ischemic Diseases. Science Advances. 2020, 6(19):eaaz8011.

  2. Gao F, Wu J, Gao H, Hu X, Liu L, Midgley AC, Liu Q, Sun Z, Liu Y, Ding D, Wang Y, Kong D*, Huang X*. Hypoxia-tropic nanozymes as oxygen generators for tumor-favoring theranostics. Biomaterials. 2020, 230:119635.

  3. Huang X#, Zhuang J#, Chung SW#, Huang B, Halpert G, Negron K, Sun X, Yang J, Oh Y, Hwang PM, Hanes J, Suk JS. Hypoxia-Tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia. ACS Nano. 2019, 13(1):236-247. (#Equally contributed)

  4. Huang X, Chisholm J, Zhuang J, Xiao Y, Parikh K, Zhang C, Chen X, Suk JS, Hanes J. Protein Nanocages that penetrate airway mucus and tumor tissue. PNAS. 2017, 114(32): E6595-E6602.

  5. Huang X#, Zhang F#, Wang Y, Sun X, Choi KY, Liu D, Cheon J, Niu G, Chen X. Design Consideration of Iron-based Nanoclusters for Non-invasive Tracking Mesenchymal Stem Cell Homing. ACS Nano. 2014, 8(5):4403-14. (#Equally contributed)

  6. Choi KY#, Silvestre OF#, Huang X#, Hida N, Liu G, Ho DN, Lee S, Lee SW, Hong JI, Chen X. A Nanoparticle Formula for Delivering siRNA or miRNAs to Tumor Cells in Cell Culture and in vivo. Nature Protoc. 2014, 9(8):1900-15. (#Equally contributed)

  7. Sun X#, Huang X#, Guo J, Niu G, Zhu W, Kiesewetter DO, Sun S, Chen X. Self-illuminating 64Cu Doped CdSe/ZnS QDs for In Vivo Tumor Imaging. J Am Chem Soc. 2014, 136(5):1706-9. (#Equally contributed)

  8. Huang X, Zhang F, Zhu L, Choi KY, Guo N, Guo J, Tackett K, Anilkumar P, Liu G, Quan Q, Choi HS, Niu G, Sun Y, Lee S, Chen X. Effect of Injection Routes on the Biodistribution, Clearance, and Tumor Uptake of Carbon Dots. ACS Nano. 2013, 7(7):5684-93.

  9. He J#, Huang X#, Li YC, Liu Y, Babu T, Aronova MA, Wang S, Lu Z, Chen X, Nie Z. Self-Assembly of Amphiphilic Plasmonic Micelle-Like Nanoparticles in Selective Solvents. J Am Chem Soc. 2013, 135(21): 7974-7984. (#Equally contributed)

  10. Huang X, Swierczewska M, Choi K, Zhu L, Bhirde A, Park J, Kim K, Xie J, Niu G, Lee K, Lee S, Chen X. Multiplex Imaging of Intracellular Proteolytic Cascade Using a Broad Spectrum Nano-Quencher. Angew Chem Int Ed Engl. 2012, 51(7):1625-30.

 

(资料来源:黄兴禄教授,2020-12-04)