发表科学论文300余篇（其中SCI收录260余篇），生物传感器和生物芯片相关专著3部。

通讯作者论文（近五年发表）

1. Minhai Chen,Chuang Yan,Yingxin Ma,Xian-En Zhang* (2021). A tandem near-infrared fluorescence complementation system with enhanced fluorescence for imaging protein-protein interactions in vivo. Biomaterials,268,DOI: 10.1016/j.biomaterials.2020.120544

2. Dianbing Wang*,Mengmeng Cui,Min Li,Xian-En Zhang* (2021). Biosensors for the Detection of Bacillus anthracis. Accounts of chemical research,DOI: 10.1021/acs.accounts.1c00407

3. YingXin Ma,Guobin Mao,Guoqiang Wu,Zongqiang Cui*,Xian-En Zhang*,Weiren Huang* (2021). CRISPR-dCas9-Guided and Telomerase-Responsive Nanosystem for Precise Anti-Cancer Drug Delivery. ACS Applied Materials & Interfaces,13(7),7890-7896.

4. Yingxin Ma,Guobin Mao,Guoqiang Wu,Minghai Chen,Fujun Qin,Luping Zheng,Xian-En Zhang* (2021).Dual-Fluorescence Labeling Pseudovirus for Real-Time Imaging of Single SARS-CoV-2 Entry in Respiratory Epithelial Cells. ACS Applied Materials & Interfaces,DOI:10.1021/acsami.1c03897.

5. Luping Zheng,Yingxin Ma,Minghai Chen,Guoqiang Wu,Chuang Yan,Xian-En Zhang* (2021). SARS-CoV-2 spike protein receptor-binding domain N-glycans facilitate viral internalization in respiratory epithelial cells. Biochemical and Biophysical Research Communications,579,69-75.

6. Yang Zheng,Qing Zhang,Ashaq Ali,Ke Li,Nan Shao,Xiaoli Zhou,Zhiqin Ye,Xiaomin Chen,Shanshan Cao,Jing Cui,Juan Zhou,Dianbing Wang,Baidong Hou,Min Li,Mengmeng Cui,Lihua Deng,Xinyi Sun,Qian Zhang,Qinfang Yang,Yong Li,Hui Wang,Yake Lei,Bo Yu,Yegang Cheng*,Xiaolin Tong*,Dong Men*,Xian-En Zhang* (2021). Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months. Virologica Sinica,36(5),869-878.

7. Chakavak Esmaeili,Jin Song,Yuliang Li,Lanqun Mao,Huibiao Liu,Fei Wu,Yanhuan Chen,Chenli Liu,Xian-En Zhang* (2021). Synthesis and Application of Graphdiyne Oxide-Polyurethane Nanocomposite Yield a Highly Sensitive Non-Enzyme Glucose Sensor. Journal of the Electrochemical Society,168(7),077520.

8. Yuwei Zhang,Juan Zhou,Yuchen Zhang,Tiangang Liu,Xiaoyun Lu,Dong Men*,Xian-En Zhang* (2021). Auxiliary Module Promotes the Synthesis of Carboxysomes in E. coli to Achieve High-Efficiency CO2 Assimilation. ACS Synthetic Biology,10(4),707-715.

9. Minghai Chen,Xian-En Zhang* (2021). Construction and applications of SARS-CoV-2 pseudoviruses: a mini review. International Journal of Biological Sciences,17(6),1574-1580.

10. Minghai Chen*,Chuang Yan,Fujun Qin,Luping Zheng,Xian-En Zhang* (2021). The intraviral protein-protein interaction of SARS-CoV-2 reveals the key role of N protein in virus-like particle assembly. International Journal of Biological Sciences,17(14),3889-3897.

11. Rui Gong,Dianbing Wang,Abbas Ghulam,Shimin Li,Qian Liu,Mengmeng Cui,Xian-En Zhang* (2021). A switch-on molecular biosensor for detection of caspase-3 and imaging of apoptosis of cells. Science China-Life Sciences,DOI:10.1007/s11427-021-1986-7.

12. Jianlin Zhang,Shimin Li,Ni Xie,Guohui Nie,Aifa Tang*,Xian-En Zhang*,Minmin Liang*,Xiyun Yan* (2021). A natural nanozyme in life is found: the iron core within ferritin shows superoxide dismutase catalytic activity. Science China-Life Sciences,DOI: 10.1007/s11427-020-1865-2.

13. Xiaohua Chen,Juan Zhou,Chen Chen,Baidong Hou,Ashaq Ali,Feng Li,Zhaolin Hua,Yingtao Wu,Qin Yang,Min Chen,Rong Zhang,Qianchuan Huang*,Jinya Ding*,Xian-En Zhang*,Dong Men* (2021). Consecutive Monitoring of Interleukin-6 Is Needed for COVID-19 Patients. Virologica Sinica,36(5),1093-1096.

14. Xiaoli Zhou,Yana Zhou,Ashaq Ali,Cuiqin Liang,Zhiqin Ye,Xiaomin Chen,Qing Zhang,Lihua Deng,Xinyi Sun,Qian Zhang,Jihong Luo,Wei Li,Kun Zhou,Shanshan Cao,Xiaowei Zhang,Xiaodong Li*,Xian-En Zhang*,Zongqiang Cui*,Dong Men* (2021). Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma. Frontiers in Immunology,12,701295.

15. Netrapal Singh,Lin Huang,Dian-Bing Wang,Nan Shao,Xian-En Zhang* (2020). Simultaneous Detection of a Cluster of Differentiation Markers on Leukemia-Derived Exosomes by Multiplex Immuno-Polymerase Chain Reaction via Capillary Electrophoresis Analysis. Analytical Chemistry,92(15):10569-10577.

16. Xia Li,Dianbing Wang,Zongqiang Cui,Qin Li,Min Li,Yinxin Ma,Qinxue Hu,Yikai Zhou*,Xian-En Zhang* (2020). HIV-1 viral cores enter the nucleus collectively through the nuclear endocytosis-like pathway. Science China-Life Sciences,DOI: 10.1007/s11427-020-1716-x.

17. Jin Song,Yiwei Li,Fang Yin,Zhitao Zhang,Dingkun Ke,Dian-bing Wang,Qipeng Yuan*,Xian-En Zhang* (2020). Enhanced Electrochemical Impedance Spectroscopy Analysis of 3Microbial Biofilms on an Electrochemically In Situ Generated Graphene Interface. ACS sensors,5(6) 1795-1803.

18. Song Lu,Dian-Bing Wang,Yu Hou,Dongge Guo,Yulin Deng*,Xian-En Zhang* (2020). Illuminating single genomic loci in live cells by reducing nuclear background fluorescence. Science China-Life Sciences,doi: 10.1007/s11427-020-1794-2.

19. Chenchen Xu,Weiwei Zhu,Hanjin Mao,Wenjing Zhang,Gen-Quan Yin,Xian-En Zhang*,Feng Li* (2020). Switch from Polymorphic to Homogenous Self-Assembly of Virus-Like Particles of Simian Virus 40 through Double-Cysteine Substitution. SMALL,DOI: 10.1002/smll.202004484.

20. Wei Feng,Ashley M. Newbigging,Connie Le,Bo Pang,Hanyong Peng,Yiren Cao,Jinjun Wu,Ghulam Abbas,Jin Song,Dian-Bing Wang,Mengmeng Cui,Jeffery Tao,D. Lome,Tyrrell,Xian-En Zhang*,Hongquan Zhang*,X. Chis Le* (2020). Molecular Diagnosis of COVID-19: Challenges and Research Needs. Analytical Chemistry,15(92),10196-10209.

21. Xian-En Zhang*. Nanobiology-Symphony of bioscience and nanoscience. Science China-Life Sciences,8(63),1099-1102.

22. Lin Huang,Ning Gu,Xian-En Zhang*,Dian-Bing Wang* (2019). Light-Inducible Exosome-Based Vehicle for Endogenous RNA Loading and Delivery to Leukemia Cells. Advanced Functional Materials,29(9):1807189.

23. Yan Xi,Dian-Bing Wang,Tingting Wang,Lin Huang,Xian-En Zhang* (2019). Quantitative Profiling of CD13 on Single Acute Myeloid Leukemia Cells by Super-resolution imaging and its Implication in Targeted Drug Susceptibility Assessment. Nanoscale,11(4):1737-1744.

24. Dongge Guo,Dian-Bing Wang,Chong Liu,Song Lu,Yu Hou,Xian-En Zhang* (2019). CRISPR-based genomic loci labeling revealed ordered spatial organization of chromatin in living diploid human cells. BBA-Molecular Cell Research,1866(12):118518.

25. Lingling Li,Chengchen Xu,Wenjing Zhang,Francesco Secundo,Chunyan Li,Zhi-Ping Zhang,Xian-En Zhang*,Feng Li* (2019). Cargo-Compatible Encapsulation in Virus-Based Nanoparticles. Nano Letters,19(4):2700-2706.

26. Tingting Wang,Guang Li,Dianbing Wang,Feng Li,Dong Men,Tao Hu,Yan Xi,and Xian-En Zhang* (2019). Quantitative profiling of integrin αvβ3 on single cells with quantum dot labeling to reveal the phenotypic heterogeneity of glioblastoma. Nanoscale,11(39):18224-18231.

27. Yiwei Li,Juan Zhou,Jin Song,Xiaosheng Liang,Zhiping Zhang,Dong Men*,Dianbing Wang,Xian-En Zhang* (2019). Chemical Nature of Electrochemical activation of Carbon Electrodes. Biosensors & Bioelectronics,144: 111534.

28. Sha Wei,Dianbing Wang,Hua Li,Lijun Bi,Jiaoyu Deng,Guofeng Zhu,Jibin Zhang,Chuanyou Li,Min Li,Yuan Fang,Guimin Zhang,Jian Chen,Shengce Tao,Xian-En Zhang* (2019). Fatty acylCoA synthetase FadD13 regulates proinflammatory cytokine secretion dependent on the NF‐κB signalling pathway by binding to eEF1A1. Cellular Microbiology,e13090.

29. Yuanyuan Chen,Zhengyan Zhan,Hongtai Zhang,Lijun Bi,Xian-En Zhang*,Yu Vincent Fu* (2019). Kinetic analysis of DNA compaction by mycobacterial integration host factor at the single-molecule level. Tuberculosis,119,101862.

30. 黄琳，王殿冰，顾宁，张先恩* (2019). 高效装载细胞内源蛋白工程化外泌体的构建. 生物工程学报，(8):1537-1545.

31. Xian-En Zhang* (2018). Forty years of highly synchronous development in China's scientific research and economy. National Science Review,5 (6):796-798.

32. Fan Yang,Xiaolei Zuo,Chunhai Fan*,Xian-En Zhang* (2018). Biomacromolecular nanostructures-based interfacial engineering: from precise assembly to precision biosensing. National Science Review,5 (5):740-755.

33. Lin Huang,Dian-Bing Wang,Netrapal Singh,Fang Yang,Ning Gu*,Xian-En Zhang* (2018). A dual-signal amplification platform for sensitive fluorescence biosensing of leukemia-derived exosomes. Nanoscale,10(43):20289-20295.

34. Ye Yuan,Dian-Bing Wang,Jibin Zhang,Ji Liu,Jian Chen,Xian-En Zhang* (2018). Raman spectra of the GFP-like fluorescent proteins. Biophysics reports,4(5):265-272.

35. Jigang Wang,Ti Fang,Ming Li,Wenjing Zhang,Zhi-Ping Zhang,Xian-En Zhang*,Feng Li* (2018). Intracellular delivery of peptide drugs using viral nanoparticles of bacteriophage P22: covalent loading and cleavable release. Journal of Materials Chemistry B,6(22):3716-3726.

36. Wen Yin,Wei Li,Qin Li,Chong Qin,Zhi-Ping Zhang,Xiaowei Zhang,Xian-En Zhang*,Zongqiang Cui* (2018). Structural Characterization and Analysis of Human Immunodeficiency Virus Encapsulating Quantum Dots. Journal of Nanoscience and Nanotechnology,18(7):4487-4494.

37. Wenjing Zhang,Xian-En Zhang*,Feng Li* (2018). Virus-Based Nanoparticles of Simian Virus 40 in the Field of Nanobiotechnology. Biotechnology Journal,13(6).

38. Dong Men,Juan Zhou,Wei Li,Cui-Hua Wei,Yuan-yuan Chen,Kun Zhou,Ying Zheng,Ke Xu,Zhi-Ping Zhang,Xian-En Zhang* (2018). Self-Assembly of Antigen Proteins into Nanowires Greatly Enhances the Binding Affinity for High-Efficiency Target Capture. ACS Appl Mater Interfaces,10(48):41019-41025.

39. Yingxin Ma,Mingxiu Wang,Wei Li,Zhiping Zhang,Xiaowei Zhang,Guoqiang Wu,Tianwei Tan,Zongqiang Cui*,Xian-En Zhang* (2017). Live Visualization of HIV-1 Proviral DNA Using a Dual-Color-Labeled CRISPR System. Analytical Chemistry,89(23):12896-12901.

40. Qin Li,Wei Li,Wen Yin,Jia Guo,Zhi-Ping Zhang,Dejun Zeng,Xiaowei Zhang,Yuntao Wu,Xian-En Zhang*,and Zongqiang Cui* (2017). Single-Particle Tracking of Human Immunodeficiency Virus Type 1 Productive Entry into Human Primary Macrophages. ACS Nano,11(4):3890-3903.

41. Yingxin Ma,Mingxiu Wang,Wei Li,Zhiping Zhang,Xiaowei Zhang,Tianwei Tan,Xian-En Zhang* & Zongqiang Cui* (2017). Live cell imaging of single genomic loci with quantum dot-labeled TALEs. Nature Communications,8:15318.

42. Kun Li,Ting Li,Shan-shan Yang,Xu-De Wang,Lei-xin Gao,Rui-Qi Wang,JingGu,Xian-En Zhang*,Jiao-Yu Deng* (2017). Deletion of nudB causes increased susceptibility to antifolates in Escherichia coli and Salmonella enterica. Antimicrobial Agents & Chemotherapy,61(5):02378-16.

43. Hua Li,Sha Wei,Yuan Fang,Min Li,Xia Li,Zhe Li,Jibin Zhang,Guofeng Zhu,Chuanyou Li,Lijun Bi,Guimin Zhang,Dianbing Wang,* and Xian-En Zhang* (2017).Quantitative proteomic analysis of host responses triggered by Mycobacterium tuberculosis infection in human macrophage cells. ABBS,49 (9):835-844.

44. Zhitao Zhang,Dianbing Wang,Chuanyou Li,Jiaoyu Deng,Jibin Zhang,Lijun Bi and Xian-En Zhang* (2017). Microbial sensor for drug susceptibility testing of Mycobacterium tuberculosis. J Appl. Microbiol,124(1):286-293.

45. Jing Gu,Yuanyuan Chen,Hongsen Guo,Manluan Sun,Mingkun Yang,Xude Wang,Xian-En Zhang*,and Jiaoyu Deng* (2017). Lysine acetylation regulates the activity of Escherichia coil pyridoxine 5'-phosphate oxidase. ABBS,49(2):186-192.

46. 张先恩* (2017). 科技强国植根于深厚的基础研究.中国科学院院刊,32(5):496-503.

47. 张先恩* (2017). 生物传感发展50年及展望. 中国科学院院刊,32(12):1271-1280.

48. 王殿冰,崔宗强,张先恩* (2017). 分子生物传感器与细胞内分子影像. 中国科学院院刊,32(12):1303-1312.

49. 张先恩*,刘云,周程,方在庆,向桂林 (2017). 基础研究内涵及投入统计的国际比较. 中国软科学,(5):131-138.

非通讯作者论文（近三年发表）

1. Ali Ashaq,Noman Muhammad,Guo Yong,Liu Xu,Zhang Rong,Zhou Juan,Zheng Yang,Xian-En Zhang,Qi Yong*,Chen Xiaohua*,Men Dong* (2021). Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality. Scientific Reports,1(1),DOI: 10.1038/s41598-021-85426-9.

2. Weiwei Zhu,Ti Fang,Wenjing Zhang,Ao Liang,Hui Zhang,Zhiping Zhang,Xian-En Zhang,Feng Li* (2021). A ROS scavenging protein nanocage for in vitro and in vivo antioxidant treatment. Nanoscale,13(8),4634-4643.

3. Hongmei Shi,Ting Li,Jintian Xu,Jifang Yu,Shanshan Yang,Xian-En Zhang,Shengce Tao,Jing Gu*,Jiao-Yu Deng* (2021). MgrB Inactivation Confers Trimethoprim Resistance in Escherichia coli. Frontiers in Microbiology,(12),6822085.

4. Wei Li,Ji Liu,Yuanyuan Liu,Qin Li,Wen Yin,Kevin K. Wanderi,Xiaowei Zhang,Zhiping Zhang,Xian-En Zhang,Zongqiang Cui* (2021). HIV-1 Uses Dynamic Podosomes for Entry into Macrophages. Journal of Virology,95(10),e02480-20.

5. Yong Yang,Xi Wang,Ronghui Du,Wei Zhang,Haorui Si,Yan Zhu,Xurui,Shen,Qian Li,Bei Li,Dong Men,Yana Zhou,Hui Wang,Xiaolin Tong,Xian-En Zhang,Zhengli Shi,Peng Zhou* (2021). Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses. Emerging Microbes & Infections,10(1),905-912.

6. Minghai Chen,Siting Li,Wei Li,Zhiping Zhang,Xiaowei Zhang,Xian-En Zhang,Feng Ge*,Zongqiang Cui* (2021). Nanoscale Imaging of RNA-Protein Interactions with a Photoactivatable Trimolecular Fluorescence Complementation System. ACS Chemical Biology,16(6),1003-1010.

7. Wenjing Zhang,Qingyan Jia， Yibo Teng,Mengsi Yang,Hui Zhang,Xian-En Zhang,Pengfei Wang,Jiechao Ge*,Sheng Cao*,Feng Li* (2021). An Ultrastable Virus-Like Particle with a Carbon Dot Core and Expanded Sequence Plasticity. Small,17(35),2101717.

8. Ruimin Gao,Xian-En Zhang,Feng Li*(2021). Generation and characterization of self-assembled protein nanocages based on beta-carboxysomes in Escherichia coli. Acta Biochimica Et Biophysica Sinca,53(7),943-949.

9. Juan Zhang,Wenjing Zhang,Mengsi Yang,Weiwei Zhu,Ming Li,Ao Liang,Hui Zhang,Ti Fang,Xian-En Zhang,Feng Li*(2021). Passive cancer targeting with a viral nanoparticle depends on the stage of tumorigenesis. Nanoscale,13(26),11334-11342.

10. Yaguo Wang,Zihui Li,Shucai Wu,Fleming Joy,Chuanyou Li,Guofeng Zhu,Bo Chen,Baiguang Ren,Xingyun Wang,Boping Du,Pingjun Li,Peilei Hu,Juwang Yang,Yi Liu,Chongchen Zhou,Xian-En Zhang,Lijun Bi,Hongtai Zhang*,Junmei Yang*,Zongde Zhang*(2021). Systematic Evaluation of Mycobacterium tuberculosis Proteins for Antigenic Properties Identifies Rv1485 and Rv1705c as Potential Protective Subunit Vaccine Candidates. Infection and Immunity,89(3). e00585-20.

11. Jie Gao,Li Zeng,Linlin Yao,Ziniu Wang,Xiaoxi Yang,Jinbo Shi,Ligang Hu,Qian Liu,Chunying Chen,Tian Xia,Guangbo Qu,Xian-En Zhang,Guibin Zhang* (2021). Inherited and acquired corona of coronavirus in the host: Inspiration from the biomolecular corona of nanoparticles. NANO TODAY,39,101161.

12. Xiao Wei Zhang,Hanzhong Wang,Yunan Sun,Mi Qi,Wei Li,Zhiping Zhang,Xian-En Zhang,Zongqiang Cui* (2020). Enterovirus A71 Oncolysis of Malignant Gliomas. Molecular Therapy,28(6),1533-1546.

13. Xuehong Min,Ti,Fang,Lingling Li,Chaoqun Li,Zhiping Zhang,Xian-En Zhang,Feng Li* (2020). AIE nanodots scaffolded by mini-ferritin protein for cellular imaging and photodynamic therapy. Nanoscale,12(4),2340-2344.

14. Wen Yin,Wei Li,Qin Li,Yuanyuan Liu,Ji Liu,Min Ren,Yingxin Ma,Zhiping Zhang,Xiaowei Zhang,Yutao Wu,Shibo Jiang,Xian-En Zhang,Zongqiang Cui* (2020). Real-time imaging of individual virion-triggered cortical actin dynamics for human immunodeficiency virus entry into resting CD4 T cells. Nanoscale,12(1)115-129.

15. Yingxin Ma,Guobin Mao,Weiren Huang,Guoqiang Wu,Wen Yin,Xinghu Ji,Zishi Deng,Zhiming Cai,Xian-En Zhang,Zhike He,Zongqiang Cui* (2019). Quantum Dot Nanobeacons for Single RNA Labeling and Imaging. Journal of the American Chemical Society,141(34):13454-13458.

16. Chong Qin,Wei Li,Qin Li,Wen Yin,Xiaowei Zhang,Zhi-Ping Zhang,Xian-En Zhang,Zongqiang Cui* (2019). Real-time dissection of dynamic uncoating of individual influenza viruses. PNAS,116(7):2577-2582.

（资料来源：张先恩研究员，2021-12-27）