发表论文

1. Zhu Y, Wang L, Li J, Zhao Y, Yu X, Liu P, Deng X, Liu J, Yang F, Zhang Y, Yu J, Lai L, Wang C, Li Z*, Wang L*, Luo T* (2024) Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (-)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice. Cell Chem Biol doi.org/10.1016/j.chembiol.2023.10.003.

2. Liu P, Hu J, Wang L* (2024) SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic. Protein & Cell 15: 79-82.

3. Cheng F, Ji Q, Wang L, Wang CC, Liu GH*, Wang L* (2023) Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H₂O₂ release. EMBO Rep 24: e56439.

(Selected as a cover story on EMBO Reports)

4. Liu P, Wang X*, Sun Y, Zhao H, Cheng F, Wang J, Yang F, Hu J, Zhang H, Wang CC, Wang L* (2022) SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases. Redox Biol 54:102388.

5. Wang L*, Wang X, Lv X, Jin Q, Shang H, Wang CC, Wang L* (2022) The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential. Redox Biol 50: 102244

6. Qiao X, Zhang Y, Ye A, Zhang Y, Xie T, Lv Z, Shi C, Wu D, Chu B, Wu X, Zhang W, Wang P, Liu GH, Wang CC, Wang L*, Chen C* (2022) Reductive stress in the endoplasmic reticulum caused by Ero1α S-nitrosation accelerates senescence. Free Radic Biol Med 180: 165-178.

7. Fan F, Zhang Q, Zhang Y, Huang G, Liang X, Wang CC, Wang L*, Lu D* (2022) Two protein disulfide isomerase subgroups work synergistically in catalyzing oxidative protein folding. Plant Physiol 188: 241-254.

8. Chen X, Zhang J, Liu P, Wei Y, Wang XE, Xiao J, Wang CC, Wang L* (2021) Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization. Proc Natl Acad Sci U S A 118: e2100133118.

9. Yan Y, Wu X, Wang P, Zhang S, Sun L, Zhao Y, Zeng GY, Liu B, Xu G, Liu H, Wang L*, Wang X* and Jiang C* (2020) Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner. Redox Biol 37: 101742.

10. Yu J, Li T, Liu Y, Wang X, Zhang J, Wang Xe, Shi G, Lou J, Wang L, Wang CC, Wang L* (2020) Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. EMBO J 39: e103841

(Highlighted by EMBO J 'News & Views'; Recommended by F1000Prime)

11. Fan F, Zhang Y, Huang G, Zhang Q, Wang CC, Wang L*, Lu D* (2019) AtERO1 and AtERO2 exhibit differences in catalyzing oxidative protein folding in the ER. Plant Physiol 180:2022-2033.

12. Zhang Y, Li T, Zhang L, Shangguan F, Shi G, Wu X, Cui Y, Wang Xe, Wang X, Liu Y, Lu B, Wei T, Wang CC, Wang L* (2019) Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer. EBioMedicine 41:408-419.

13. Wu X, Zhang L, Miao Y, Yang J, Wang X, Wang CC, Feng J*, Wang L* (2019) Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis. Redox Biol 20: 46-59.

14. Zhang J, Zhu Q, Wang Xe, Yu J, Chen X, Wang J, Wang X, Xiao J, Wang CC, Wang L* (2018) Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α. EMBO J 37: e98699.

15. Fang J, Yang J, Wu X, Zhang G, Li T, Wang Xe, Zhang H, Wang CC, Liu GH*, Wang L* (2018) Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. Aging Cell 17: e12765.

16. Li H, Yang K, Wang W, Niu Y, Li J, Dong Y, Liu Y, Wang CC, Wang L*, Liang H* (2018) Crystal and solution structures of human protein disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity. J Biol Chem 293, 1192-1202.

17. Fan F, Zhang Y, Wang S, Han Y, Wang L*, Lu D* (2018) Characterization of the oxidative protein folding activity of a unique plant oxidoreductase, Arabidopsis protein disulfide isomerase-11. Biochem Biophys Res Commun 495:1041-1047.

18. Niu Y, Zhang L, Yu J, Wang CC* and Wang L* (2016) Novel roles of the non-catalytic elements of yeast protein-disulfide isomerase in its interplay with endoplasmic reticulum oxidoreductin 1. J Biol Chem 291:8283-8294.

19. Zhang L, Niu Y, Zhu L, Fang J, Wang Xe, Wang L* and Wang CC* (2014) Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α). J Biol Chem 289:31188-31199.

20. Wang L*, Zhang L, Niu Y, Sitia R and Wang CC* (2014) Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding. Antioxid Redox Signal 20: 545-556.

21. Wang L, Zhu L and Wang CC (2011) The Endoplasmic Reticulum Sulphydryl Oxidase Ero1β Drives Efficient Oxidative Protein Folding with Loose Regulation. Biochem J 434:113-121.

22. Wang L, Li SJ, Sidhu A, Zhu L, Liang Y, Freedman RB, and Wang CC* (2009) Reconstitution of human Ero1-Lα/protein disulfide isomerase oxidative folding pathway in vitro: position-dependent differences in role between the a and a' domains of protein disulfide isomerase. J Biol Chem 284: 199-206.

综述 & 评论 (*责任作者)

1. Cheng F, Wang L* (2024) Slowing down the central dogma rate for alleviating aging. Innovation Life 2: 100049.

2. 胡昕炜, 王志珍, 王磊* (2023)"后AlphaFold时代"的蛋白质折叠问题. 《科学通报》 68: 2943-2950.

3. Wang L*, Wang CC (2023) Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum. Trends Biochem Sci 48: 40-52.

4. Wang L*, Yu J, Wang CC (2021) Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities and pathophysiological functions. BioEssays 43: e2000147.

5. Wang L, Wang X, Wang CC* (2015) Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone. Free Radical Bio Med 83:305-313.

6. 王曦, 王磊, 陈畅, 王志珍 (2014) 未折叠蛋白响应: 2014年拉斯克基础医学研究奖解读. 《科学通报》59: 3533-3534.

全部发表论文

https://scholar.google.com/citations?hl=en&user=NUni5KMAAAAJ

ORCID: 0000-0002-5071-5800

（资料来源：王磊研究员，2024-02-02）