发表论文

1.Zhu X, Hong S, Bu J, Liu Y, Liu C, Li R, Zhang T, Zhang Z, Li L, Zhou X, Hua Z*, Zhu B*, Hou B*. Antiviral memory B cells exhibit enhanced innate immune response facilitated by epigenetic memory. Sci Adv. 2024 Mar 29;10(13):eadk0858. doi: 10.1126/sciadv.adk0858. Epub 2024 Mar 29. PMID: 38552009; PMCID: PMC10980274.

2.Cao S, Zhang Q, Song L, Xiao M, Chen Y, Wang D, Li M, Hu J, Lin L, Zheng Y, Zhou K, Ye S, Zhou J, Zhou YN, Cui J, Wang J, Sun J, Tao J, Chen Z, Chen R, Zhou P, Shi Z, Wei S, Zhao L, Wang H*, Tong X*, Li X*, Men D*, Hou B*, Zhang XE*. Dysregulation of Innate and Adaptive Immune Responses in Asymptomatic SARS-CoV-2 Infection with Delayed Viral Clearance. Int J Biol Sci. 2022 Jul 11;18(12):4648-4657. doi: 10.7150/ijbs.72963. PMID: 35874943; PMCID: PMC9305270.

3. Guo C, Peng Y, Lin L, Pan X, Fang M, Zhao Y, Bao K, Li R, Han J, Chen J, Song TZ, Feng XL, Zhou Y, Zhao G, Zhang L, Zheng Y, Zhu P, Hang H, Zhang L, Hua Z*, Deng H*, Hou B*. A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates. Cell Rep Med. 2021 Nov 16;2(11):100448. doi: 10.1016/j.xcrm.2021.100448. Epub 2021 Oct 23. PMID: 34723223; PMCID: PMC8536523.

4. Lin X, Twelkmeyer T, Zhu D, Zhang L, Zhao Y, Zhang C, Iwakura Y, Meng G, Hua Z, Yan B, Liu WJ, Luo Z, Gong S, Chen H, Li S*, Hou B*, Tang H*. Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2019798118. doi: 10.1073/pnas.2019798118. PMID: 33875594; PMCID: PMC8092388.

5. Hua Z*, Hou B*. The role of B cell antigen presentation in the initiation of CD4⁺ T cell response. Immunol Rev. 2020 Apr 18. doi: 10.1111/imr.12859. [Epub ahead of print] Review. PMID:32304104

6. Hong S, Zhang Zhimin, Liu H, Tian M, Zhu X, Zhang Zhuqiang, Wang W, Zhu B, Zhou X, Zhang F, Ge Q, Tang H*, Hua Z*, Hou B*. B cells are the dominant antigen-presenting cells that activate naive CD4⁺ T cells upon immunization with a virus-derived nanoparticle antigen. Immunity, 2018, Sep 21. pii: S1074-7613(18)30353-4. doi: 10.1016/j.immuni.2018.08.012. [Epub ahead of print]

◆ Selected and recommended by Faculty of 1000.

7. Tian M, Hua Z, Hong S, Zhang Z, Liu C, Lin L, Chen J, Zhang W, Zhou X, Zhang F, DeFranco AL and Hou B*. B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle. J Immunol. 2018 February 1. 200 (3) 937-948. PMID: 29282308

8. Liao W, Hua Z, Liu C, Lin L, Chen R, Hou B*. Characterization of T-Dependent and T-Independent B Cell Responses to a Virus-like Particle. J Immunol. 2017 May 15. PMID:28416599

9. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B*, DeFranco AL*. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014 Feb 1;192(3):875-85. PMID: 24379120

10. Hua Z, Hou B*. TLR signaling in B cell development and activation. Cell. Mol. Immunol., Vol.10, 103-106, 2013. PMID: 23241902

11. DeFranco AL, Rookhuizen D, Hou B. Contribution of TLR signaling to germinal center antibody responses. Immunological reviews. 2012 May;247(1):64-72. PMID: 22500832.

12. Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, Defranco AL, Yarovinsky F. B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage. Immunity. 2012 Feb 24;36(2):228-38. PMID: 22306056.

13. Hou B*, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee L, Coffman R, Bachmann M, DeFranco AL*. Selective utilization of TLR/MyD88 signaling in B cells for enhancement of the anti-viral germinal center response. Immunity 2011 Mar 25;34(3):375-84. PMID: 21353603.

◆ Selected and recommended by Faculty of 1000.

14. Hou B*, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F*. Critical coordination of innate immune defense to Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci USA. 2011 Jan 4;108(1):278-83. PMID: 21173242.

15. Hou B, Reizis B, DeFranco AL. Toll-like receptor-mediated dendritic cell-dependent and –independent stimulation of innate and adaptive immunity. Immunity 2008 Aug; 29(2): 272-82. PMID: 18656388.

◆ Highlighted in News View. Immunity 2008

◆ Selected and evaluated for the Faculty of 1000

专利

1. 活化CD4+ T细胞的方法，发明人：侯百东；洪胜；华兆琳；唐宏；专利号：ZL 2019 8 0052317.0

2. 病原样抗原疫苗及其制备方法，发明人：侯百东；华兆琳；郭畅；专利号：ZL 2020 1 1480939.4

3. 针对新型冠状病毒感染的疫苗组合物，发明人：侯百东；专利号：ZL 2020 1 1480978.4

（资料来源：侯百东研究员，2024-09-13）