发表论文

1. Xue B, Wang P, Yu W, Feng J, Li J, Zhao R, Yang Z*, Yan X*, Duan H*. CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases. Sci China Life Sci. 2021, Oct 29. doi: 10.1007/s11427-021-2020-0. Online ahead of print.

2. Duan H^#, Jing L^#, Jiang X, Ma Y, Wang D, Xiang J, Chen X, Wu Z, Yan H, Jia J, Liu Z, Feng J, Zhu M*, Yan X*. CD146 bound to LCK promotes TCR signaling and anti-tumor immune response in mice. J Clin Invest. 2021, Nov 1;131(21):e148568. doi: 10.1172/JCI148568.

3. Chen X^#, Yan H^#, Liu D, Xu Q, Duan H, Feng J*, Yan X*, Xie C*. Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146. iScience. 2021, Apr 14;24(5):102417. doi:10.1016/j.isci.2021.102417. eCollection 2021 May 21

4. Hongxia Duan^#*, Shuai Zhao^#, Jianquan Xiang^#, Chenhui Ju, Xuehui Chen, Irene Gramaglia and Xiyun Yan*. Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier against experimental cerebral malaria. Cell Mol Immunol. 2021, Oct;18(10):2443-2454. doi: 10.1038/s41423-020-00582-8. Epub 2020 Nov 17.

5. DUAN Hongxia^# , XIONG Chaoliang^# , JING Lin^# , XU Qingji , LIU Jingyu ,MA Xinran , WANG Daji , XIANG Jianquan , HE Zhiheng , FENG Jing , YAN Xiyun. Review and prospect of CD146 research, 中国科学: 生命科学. 2020, doi: 10.1360/SSV-2020-0238.

6. Daji Wang^#, Hongxia Duan^#, Jing Feng, Jianquan Xiang, Liqun Feng, Dan Liu, Xuehui Chen, Lin Jing, Zheng Liu, Dexi Zhang, Hongjun Hao, Xiyun Yan. Soluble CD146, a cerebrospinal fluid marker for neuroinflammation, promotes blood-brain barrier dysfunction. (#Co-first author) Theranostics. 2020, Vol. 10, Issue 1.

7. Shuai Zhao, Hongxia Duan, Yili Yang, Xiyun Yan*, Kelong Fan*. Fenozyme Protects the Integrity of the Blood–Brain Barrier against Experimental Cerebral Malaria. Nano Lett. 2019.

8. Yongting Luo^#, Hongxia Duan^#, Yining Qian^#, Liqun Feng, Zhenzhen Wu, Jing Feng, Dongling Yang, Zhihai Qin, Xiyun Yan. Macrophage CD146 promotes atherosclerosis by trapping macrophages in the plaques. (#Co-first author) Cell Res. 2017, Mar;27(3):352-372 

9. Duan H, Xing S, Luo Y, Feng L, Gramaglia I, Zhang Y, Lu D, Zeng Q, Fan K, Feng J, Yang D, Qin Z, Couraud PO, Romero IA, Weksler B, Yan X. Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS. Sci Rep. 2013, 3:1687.

10. Duan H, Luo Y, Hao H, Feng L, Zhang Y, Lu D, Xing S, Feng J, Yang D, Song L, Yan X. Soluble CD146 in cerebrospinal fluid of active multiple sclerosis. Neuroscience. 2013, Apr 3;235:16-26.   

11. Jiang T, Zhuang J, Duan H, Luo Y, Zeng Q, Fan K, Yan H, Lu D, Ye Z, Hao J, Feng J, Yang D, Yan X. CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. Blood. 2012, Sep 13;120(11):2330-9. 

12. Zeng Q, Li W, Lu D, Wu Z, Duan H, Luo Y, Feng J, Yang D, Fu L, Yan X. CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer.Proc Natl Acad Sci U S A. 2012, Jan 24;109(4):1127-32.

13. Qian YN, Luo Y, Duan HX, Feng LQ, Bi Q, Wang YJ, Yan XY. Adhesion Molecule CD146 and its Soluble Form Correlate Well with Carotid Atherosclerosis and Plaque Instability. CNS Neurosci Ther. 2014, 20(5):438-45.

14. Shu Xing, Luo Y, Zhihua Liu, Pengcheng Bu, Hongxia Duan, Dan Liu, Ping Wang, Jing Yang, Lina Song, Jing Feng, Dongling Yang, Zhihai Qin, Xiyun Yan. Targeting endothelial CD146 attenuates colitis and prevents colitis-associated-carcinogenesis. Am J Pathol. 2014, 184:1604-16.

15. Wang P, Luo Y, Duan H, Xing S, Zhang J, Lu D, Feng J, Yang D, Song L, Yan X. MicroRNA-329 suppresses angiogenesis by targeting CD146. Mol Cell Biol. 2013, 33(18):3689-99.

16. Zeng Q, Wu Z, Duan H, Jiang X, Tu T, Lu D, Luo Y, Wang P, Song L, Feng J, Yang D, Yan X. Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice. Protein Cell, 2014, 5(6):445-56.

17. Gao Q, Chen X, Duan H, Wang Z, Feng J, Yang D, Song L, Zhou N, Yan X. FXYD6: a novel therapeutic target toward hepatocellular carcinoma. Protein Cell. 2014, Jul;5(7):532-43.

申请发明专利

1. 阎锡蕴，罗永挺，段红霞，冯立群，卢迪，冯静，杨东玲，CD146及其抗体诊断和治疗自身免疫病等炎症性疾病的应用，专利号ZL 2011 1 0188035.9；

2. 阎锡蕴，姜天霞，罗永挺，段红霞，卢迪，杨东玲，冯静，靶向作为 VEGFR-2共受体 CD146 的功能在抗肿瘤血管新生治疗中的应用，专利号：201210223311.5；

3. 阎锡蕴，王平，罗永挺，段红霞，冯静，杨东玲，宋丽娜，CD146作为预防和/或治疗缺血性眼部疾病的药物靶点的应用，专利号：201310295008；

4. 阎锡蕴，曾启群，吴真真，卢迪，段红霞，罗永挺，杨东玲，冯静，CD146及其抗体诊断和治疗三阴性乳腺癌的应用，专利号：201110412778.X；

5. 曾小峰，阎锡蕴，张令令，李梦涛，张德玺，段红霞，罗永挺，CD146作为分子标记物在诊断、分期或预后神经精神性狼疮中的作用，专利号：201410350619.51.

（资料来源：段红霞副研究员，2021-11-08）