中国科学院青年创新促进会会员
1999.09 - 2003.07 北京大学药学院,理学学士
2003.09 - 2009.12 中国科学院生物物理研究所,理学博士(导师:常文瑞院士)
2010.01 - 2011.12 中国科学院生物物理研究所,助理研究员
2011.12 - 2020.12 中国科学院生物物理研究所,副研究员
2018年 入选中国科学院青年创新促进会会员
2011年 英国David Blow学生奖学金
2009年 中国科学院三好学生
2008年 中国科学院三好学生
2007年 中国科学院优秀学生干部
2003年 北京大学优秀毕业生
2003年 北京市优秀毕业生
光合作用是地球上最重要的化学反应之一。蓝细菌、藻类和高等植物等放氧光合生物在利用太阳能将二氧化碳转变为有机物的同时,还能释放出氧气,为地球上几乎所有生物体提供赖以生存的物质和能量。放氧光合生物都有两个光系统,分别是光系统I和光系统II,它们都由反应中心和捕光天线组成。捕光天线负责吸收太阳光能并传递到反应中心,在反应中心发生电荷分离和水裂解反应,释放氧气。光合生物为了适应不断变化的自然环境,进化出一系列的调控机制,包括非化学能量淬灭、状态转换和环式电子传递等。我们主要利用结构生物学手段,综合运用X-射线晶体学和冷冻电子显微镜技术来研究光合作用相关的膜蛋白复合体的结构及功能,揭示光合生物进行光能捕光、能量传递、光保护、状态转换和环式电子传递等一系列重要过程的分子机理及调控机制。目前的主要研究进展包括:
1. 揭示了蓝藻环式电子传递过程的分子机理(Nat Commun,2020)。
2. 解析了绿藻光系统I复杂的天线系统结构及色素网络,揭示了其高效捕光和能量传递的分子机理(Nat Plants,2019)。
3. 阐明了在不断变换的自然光环境中,高等植物两个光系统进行能量平衡分配的状态转换机制(Science,2018; BBA Bioenerg, 2020)。
4. 揭示了高等植物光系统II捕光天线CP29捕光和能量传递的分子机制,发现了其潜在的能量淬灭中心(Nat Struct Mol Biol, 2011; Curr Opin Struct Biol, 2013)。
蓝藻环式电子传递复合物NDH-Fd冷冻电镜结构(Pan X, Cao D, Xie F, Xu F, et al. Nat commun,2019)
衣藻PSI-8LHCI(a)及PSI-10LHCI(b)复合体的三维结构(Su X, Ma J, Pan X, et al. Nat Plants,2019)
玉米状态转换复合物PSI-LHCI-LHCII的三维结构(Pan X, Ma J, Su X, et al. Science, 2018)
菠菜捕光复合物CP29晶体结构(Pan X,et al. Nat Struct Mol Biol, 2011)
1. Pan X*; Cao D*, Xie F*; Xu F*; Su X; Mi H#; Zhang X#; Li M# (2020) Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase, Nature Communications 11:610.
2. Pan X; Cao P; Su X; Liu Z; Li M# (2020) Structural analysis and comparison of light-harvesting complexes I and II, Biochim Biophys Acta Bioenerg 1861: 148038.
3. Cao P; Pan X; Su X; Liu Z; Li M# (2020) Assembly of eukaryotic photosystem II with diverse light-harvesting antennas, Curr Opin Struct Biol 63: 49-57.
4. Yu A*; Xie Y*; Pan X; Zhang H; Su X; Cao P; Chang W; Li M# (2020) Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle. The Plant Cell 32: 1556-1573.
5. Gao Y*; Zhang H*; Fan M; Jia C; Shi L; Pan X; Cao P; Zhao X; Chang W; Li M# (2020) Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase, Nature Communications 11: 1525
6. Su X*, Ma J*, Pan X*, Zhao X, Chang W, Liu Z, Zhang X#, Li M# (2019) Antenna arrangement and energy transfer pathways of a green algal photosystem-I-LHCI supercomplex. Nat Plants 5: 273-281.
7. Pan X*, Ma J*, Su X*, Cao P, Chang W, Liu Z, Zhang X#, Li M# (2018) Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II. Science 360: 1109-1113.
8. Cao P, Su X, Pan X, Liu Z, Chang W, Li M# (2018) Structure, assembly and energy transfer of plant photosystem II supercomplex. Biochim Biophys Acta Bioenerg 1859: 633-644.
9. Fox KF, Unlu C, Balevicius V, Jr., Ramdour BN, Kern C, Pan X, Li M, van Amerongen H, Duffy CDP# (2018) A possible molecular basis for photoprotection in the minor antenna proteins of plants. Biochim Biophys Acta Bioenerg 1859: 471-481.
10. Cao P*, Xie Y*, Li M#, Pan X, Zhang H, Zhao X, Su X, Cheng T, Chang W# (2015) Crystal structure analysis of extrinsic PsbP protein of photosystem II reveals a manganese-induced conformational change. Mol Plant 8: 664-666.
11. Fan M, Li M#, Liu Z, Cao P, Pan X, Zhang H, Zhao X, Zhang J, Chang W# (2015) Crystal structures of the PsbS protein essential for photoprotection in plants. Nat Struct Mol Biol 22: 729-735.
12. Jia C, Li M#, Li J, Zhang J, Zhang H, Cao P, Pan X, Lu X, Chang W# (2015) Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases. Protein Cell 6: 55-67.
13. Zhang H, Li M#, Gao Y, Jia C, Pan X, Cao P, Zhao X, Zhang J, Chang W# (2015) Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation. Protein Cell 6: 147-151.
14. Feng X, Pan X, Li M, Pieper J, Chang W, Jankowiak R# (2013) Spectroscopic study of the light-harvesting CP29 antenna complex of photosystem II--part I. J Phys Chem B 117: 6585-6592.
15. Guo J, Wei X, Li M, Pan X, Chang W#, Liu Z# (2013) Structure of the catalytic domain of a state transition kinase homolog from Micromonas algae. Protein Cell 4: 607-619.
16. Pan X, Liu Z#, Li M, Chang W# (2013) Architecture and function of plant light-harvesting complexes II. Curr Opin Struct Biol 23: 515-525.
17. Pan X, Li M, Wan T, Wang L, Jia C, Hou Z, Zhao X, Zhang J, Chang W# (2011) Structural insights into energy regulation of light-harvesting complex CP29 from spinach. Nat Struct Mol Biol 18: 309-315.
18. Peng S, Zhang H, Gao Y, Pan X, Cao P, Li M, Chang W# (2011) Crystal structure of uroporphyrinogen III synthase from Pseudomonas syringae pv. tomato DC3000. Biochem Biophys Res Commun 408: 576-581.
19. Wang L, Zhao F, Li M, Zhang H, Gao Y, Cao P, Pan X, Wang Z, Chang W# (2011) Conformational Changes of rBTI from Buckwheat upon Binding to Trypsin: Implications for the Role of the P-8 ' Residue in the Potato Inhibitor I Family. Plos One 6:1-7.
20. Pan X, Zhang H, Gao Y, Li M, Chang W# (2009) Crystal structures of Pseudomonas syringae pv. tomato DC3000 quinone oxidoreductase and its complex with NADPH. Biochem Biophys Res Commun 390: 597-602.
21. Li M, Chen Z, Zhang P, Pan X, Jiang C, An X, Liu S, Chang W# (2008) Crystal structure studies on sulfur oxygenase reductase from Acidianus tengchongensis. Biochem Biophys Res Commun 369: 919-923.
22. Li M, Zhang P, Pan X, Chang W# (2007) Crystal structure study on human S100A13 at 2.0 Å resolution. Biochem Biophys Res Commun 356: 616-621.
23. Li M*, Li Y*, Chen J*, Wei W, Pan X, Liu J, Liu Q, Leu W, Zhang L, Yang X#, Lu J, Wang K (2007) Copper ions inhibit S-adenosylhomocysteine hydrolase by causing dissociation of NAD+ cofactor. Biochemistry 46: 11451-11458.
1. 潘晓伟*,李梅,柳振峰,常文瑞。光合作用光反应中的重要蛋白及复合物的结构生物学研究进展,《新生物学年鉴2012》,科学出版社,2013.2.1,ISBN:9787030364036。
(资料来源:潘晓伟副研究员,2020-06-08)