朱玲----中国科学院生物物理研究所

朱玲　/　博士副研究员

中国科学院青年创新促进会会员

研究方向：病毒结构生物学

电子邮件：lingzhu@ibp.ac.cn

电　　话：010-64888554

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_zkyqchhy/202005/t20200519_339574.html

基本情况研究方向代表成果人才培养团队风采

简历

2005 - 2009 四川大学生命科学学院，理学学士p>

2009 - 2012 四川大学华西医院生物治疗国家重点实验室，医科硕士

2013 - 2017 牛津大学医学科学院，理学博士

2018 - 至今中国科学院生物物理研究所，副研究员

获奖及荣誉

社会任职

承担项目情况

1. 国家自然科学基金委青年基金，小RNA病毒科C亚科重要病原体2A蛋白的结构与功能研究，2019-2021，主持

2. 国家重点研发计划非公开项目课题，2018-2021，主持

3. 中国科学院战略性先导专项，病原体宿主适应与免疫干预，2018-2023，参与

　　小RNA病毒家族是一类无包膜、由正二十面体衣壳蛋白包裹着单股正链RNA病毒，家族成员可导致人手足口病、甲型肝炎、脊髓灰质炎等多种疾病。使用结构生物学、细胞生物学等技术手段，揭示小RNA病毒入侵宿主细胞、病毒脱衣壳的分子机制，设计抑制病毒入侵的小分子药物；筛选稳定性好和免疫原性佳的候选疫苗。

1. Zhu L^#*, Sun Y^#, Fan J^#, Zhu B, Cao L, Gao Q, Zhang Y, Liu H, Rao Z*, Wang X*. Structures of CoxsackievirusA10 shed light on the molecular mechanisms of receptor binding and uncoating of enteroviruses. Nature Communications, 2018 , 2018, 9: 4985.

2. Zhu L^#, Xu K^#, Wang N^#, Cao L, Wu J, Gao Q, Fry E.E, Stuart D.I, Rao Z, Wang J, Wang X*. Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71. Mbio. 2018, 01013-18.

3. Zhu L^#, Wang X^#, Ren J, Kotecha A, Walter T.S, Yuan S, TuthillT.J, Fry E.E, Rao Z* and Stuart D.I*. Structure of human Aichi virus and implications for receptor binding. Nature Microbiology. 2016.9.5, 1 (11):16150~16150

4. Zhu L^#, Wang X^#, Ren J, Porta C, Wenham H, Ekstrom J, Panjwani A, Knowles N.J, Kotecha A, Siebert A.C, A. Lindberg M, Fry E.E, Rao Z and Stuart D.I. Structure of Ljungan virus reveals a novel mechanism for picornavirus genome packaging. Nature Communications. 2015,6:8316.

5. Zhu L, Zhang X. Hepatitis A virus exhibits a structure unique among picornaviruses, Protein & Cell. 2015, 6(2):79–80.

6. Wang X^#*, Zhu L^#, Dang M^#, Hu Z^#, Gao Q, Yuan S, Sun Y, Zhang B, Ren J, Wang J, Fry E.E*, Stuart D.I* and Rao Z*. Potent neutralization of Hepatitis A virus reveals effected by a receptor mimic mechanism. Proc Natl Acad Sci U S A, 2017.1.24, 114(4):770~775.

7. Wang X^#, Li S^#, Zhu L^#, Nian Q^#, Gao Q, Nian Q, Hu Z, Fry E.E, Qin C*, Stuart D.I* and Rao Z*. Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability, Nature Communications, 2017, 10.1038.

8. Ren J^#, Wang X^#, Zhu L^#,Hu Z^#, Li X, Wang J, Fry E.E, Rao Z* and Stuart D.I*. Structures of coxsackievirusA16 capsids with native antigenicity, implications for particle expansion, receptor binding and immunogenicity. Journal of Virology. 2015. 89 (20) :10500-10511.

9. Xie D, Liu Z, Nian Q, Zhu L, Wang N, Deng Y, Zhao H, Ji X, Li X, Wang X, Shi P & Qin C. A single residue in the αB helix of the E protein is critical for Zika virus thermostability. Emerging Microbes &Infections , 2018.10.1038/s41426-017-0006-9.

（资料来源：朱玲副研究员，2020-10-27）