中国科学院青年创新促进会会员
2006.09 – 2010.06 武汉大学生命科学学院,学士
2010.09 – 2019.03 北京生命科学研究所/北京师范大学,博士
2019.03 – 2021.11 中国科学院生物物理所,博士后
2021.11 – 2022.01 中国科学院生物物理所,助理研究员
2022.01 – 至今 中国科学院生物物理所,副研究员
国家自然科学基金青年基金项目(32000559),2021-2023,负责人。
我们运用多学科前沿技术,致力于研究发育与疾病过程中的染色质调控机制:
1. 哺乳动物早期胚胎染色质编程与重编程机制研究;
2. 染色质调控蛋白突变的致病机制研究。
1. Zhang J#, Zhang Y#, You Q#, Huang C, Zhang T, Wang M, Zhang T, Yang X, Xiong J, Li Y, Liu C-P, Zhang Z, Xu R-M*, Zhu B*. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science. 2022, 375(6584): 1053-1058.
2. Ming X, Zhu B*, Li Y*. Mitotic inheritance of DNA methylation: more than just copy and paste. Journal of Genetics and Genomics. 2021, 48(1): 1-13.
3. Ming X#, Zhang Z#, Zou Z, Lv C, Dong Q, He Q, Yi Y, Li Y, Wang H, Zhu B*. Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration. Cell Res. 2020, 30(11): 980-996.
4. Du W, Dong Q, Zhang Z, Liu B, Zhou T, Xu R-m, Wang H, Zhu B, Li Y*. Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1. J Biol Chem. 2019, 294(22): 8907-8917.
5.Li Y#, Zhang Z#, Chen J#, Liu W, Lai W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y, Zhang P, Fan G, Wong J, Xu G-L, Wang Z, Wang H, Gao S, Zhu B*. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1. Nature. 2018, 564(7734): 136-140.
6. Li X, Shang E, Dong Q, Li Y, Zhang J, Xu S, Zhao Z, Shao W, Lv C, Zheng Y, Wang H, Lei X, Zhu B*, Zhang Z*. Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway. J Biol Chem. 2018, 293(19): 7423-7436.
7. Huang C#, Zhang Z#, Xu M, Li Y, Li Z, Ma Y, Cai T, Zhu B*. H3.3-H4 Tetramer Splitting Events Feature Cell-Type Specific Enhancers. PLoS Genet. 2013, 9(6): e1003558.
8. Wu H, Chen X, Xiong J, Li Y, Li H, Ding X, Liu S, Chen S, Gao S, Zhu B*. Histone methyltransferase G9a contributes to H3K27 methylation in vivo. Cell Res. 2011, 21(2): 365-367.
(资料来源:李颖峰副研究员,2022-03-22)