网站地图 联系我们搜索内部网English | 中国科学院
首页 所况简介 机构设置 科研队伍 科学研究平台 院地合作 党群园地 国际交流 博士后 研究生教育 信息公开
科研进展
成果报道
最新重要论文(影响因子PNAS及以上)
发表论文数据库
所级学术报告
科学成果
发表论文
专著
专利
获奖
专题
所史丛书
所庆专辑
建所50周年画册
现在位置:首页 > 科研进展 > 最新重要论文(影响因子PNAS及以上)
Fenozyme Protects the Integrity of Blood Brain Barrier against Experimental Cerebral Malaria, Nano letters, 01 Nov 2019
2019-11-01 | 【     】【打印】【关闭

Nano letters01 November, 2019,DOI:https://doi.org/10.1021/acs.nanolett.9b03774

Fenozyme Protects the Integrity of Blood Brain Barrier against Experimental Cerebral Malaria

Shuai Zhao, Hongxia Duan, Yili Yang, Xiyun Yan and Kelong Fan

Abstract

Cerebral malaria is a lethal complication of malaria infection characterized by central nervous system dysfunction, and is often not effectively treated by the anti-malaria combination therapies. It has been shown that the sequestration of the parasite infected red blood cells that interact with cerebral vessel endothelial cells and the damage of the blood-brain barrier (BBB) play critical roles in the pathogenesis. In this study, we developed a ferritin nanozyme (Fenozyme) composed of recombinant human ferritin (HFn) protein shells that specifically target to BBB endothelial cells (BBB ECs), and inner Fe3O4 nanozyme core that exhibits reactive oxygen species-scavenging catalase-like activity. In the experimental cerebral malaria (ECM) mouse model, administration of the Fenozyme, but not HFn, markedly ameliorated the damage of BBB induced by the parasite and improved the survival rate of infected mice significantly. Further investigations found that Fenozyme, as well as HFn, was able to polarize the macrophages in liver to M1 phenotype and promote the elimination of malaria in the blood. Thus, the catalase-like activity of the Fenozyme is required for its therapeutic effect in the mouse model. Moreover, the Fenozyme significantly alleviated the brain inflammation and memory impairment in ECM mice that had been treated with artemether, indicating that combining Fenozyme with anti-malaria drug is a novel strategy for the treatment of cerebral malaria.

文章链接:https://pubs.acs.org/doi/10.1021/acs.nanolett.9b03774

相关报道:http://www.ibp.cas.cn/kyjz/zxdt/201911/t20191104_5420434.html

 

 

评 论
          
版权所有:中国科学院生物物理研究所     京ICP备05002792号 京公网安备 110402500011 号
地址:北京市朝阳区大屯路15号(100101) 电话:010-64889872
意见反馈联系人:侯文茹 电子邮件:houwenru@ibp.ac.cn