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现在位置:首页 > 科研进展 > 最新重要论文(影响因子PNAS及以上)
Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila,Cell Host & Microbe, 14 Aug 2019
2019-08-14 | 【     】【打印】【关闭

Cell Host & Microbe14 August, 2019,DOI:http://dx.doi.org/10.1016/j.chom.2019.07.001

Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila

Shuo Yang, Yaya Zhao, Junjing Yu, Zhiqin Fan, Si-tang Gong, Hong Tang, Lei Pan

Summary

Interorgan immunological communication is critical to connect the local-systemic innate immune response and orchestrate a homeostatic host defense. However, the factors and their roles in this process remain unclear. We find Drosophila IMD response in guts can sequentially trigger a systemic IMD reaction in the fat body. Sugar alcohols of the polyol pathway are essential for the spatiotemporal regulation of gut-fat body immunological communication (GFIC). IMD activation in guts causes elevated levels of sorbitol and galactitol in hemolymph. Aldose reductase (AR) in hemocytes, the rate-limiting enzyme of the polyol pathway, is necessary and sufficient for the increase of plasma sugar alcohols. Sorbitol relays GFIC by subsequent activation of Metalloprotease 2, which cleaves PGRP-LC to activate IMD response in fat bodies. Thus, this work unveils how GFIC relies on the intermediate activation of the polyol pathway in hemolymph and demonstrates that AR provides a critical metabolic checkpoint in the global inflammatory response.

文章链接:https://www.sciencedirect.com/science/article/pii/S1931312819303452?via%3Dihub

 

 

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