Nature Methods, 09 September, 2019，DOI：https://doi.org/10.1038/s41592-019-0544-2
Molecular resolution imaging by repetitive optical selective exposure
Lusheng Gu, Yuanyuan Li, Shuwen Zhang, Yanhong Xue, Weixing Li, Dong Li, Tao Xu & Wei Ji
We introduce an interferometric single-molecule localization method for super-resolution fluorescence microscopy. Fluorescence molecules are located by the intensities of multiple excitation patterns of an interference fringe, providing around a twofold improvement in the localization precision compared with the conventional imaging with the same photon budget. We demonstrate this technique by resolving nanostructures down to 5 nm in size over a large 25 × 25 μm2 field of view.