中科院青促会会员

　　2007.09 – 2011.07  复旦大学，理学学士

　　2011.09 – 2016.06  中国科学院大学，理学博士

　　2016.07 – 2019.11  中国科学院生物物理研究所，助理研究员

　　2019.12 – 至今        中国科学院生物物理研究所，高级工程师

　　超高场（≥ 7 Tesla）磁共振成像（Magnetic Resonance Imaging, MRI）具有卓越的信噪比和对比度，可无创的获得亚毫米尺度的医学影像和功能影像，为脑疾病和脑科学的研究开辟了新的视野。我们基于7T MRI平台开发多种模态的脑血管成像和脑功能成像技术，并探索其应用价值。

　　1. 国家自然科学基金青年项目（82001804），基于7T超高场磁共振的同时多层采集和超分辨重建的颅内动脉粥样硬化斑块成像方法研究，2021-2023，主持。

　　2. 北京市自然科学基金青年项目（7184226），基于局部激发的7T高分辨颅内穿支动脉管壁成像技术研发，2018-2019，主持。

　　3. 科技部国家重点研发计划（2017YFC1307904），症状性颅内外大动脉狭窄复发进展预测模型与干预策略研究，2017-2020，骨干。

　　4. 国家自然科学基金中美合作与交流项目（81961128030），基于多模态影像学的CADASIL血脑屏障破坏机制研究，2020-2024，骨干。

　　5. 北京市自然科学基金重点项目（7191003），基于神经网络深度学习的脑卒中相关血管管壁斑块量化分析及破裂风险预警模型研究，2020-2023，骨干。

　　6. 北京市卫健委首都卫生发展科研专项（首发2020-2-5115），脑深部髓静脉形态与脑小血管病认知障碍的相关性研究，2017-2023，骨干。

　　7. 科技部国家重点研发计划（2015CB351701），视觉认知的脑工作机理及高级脑机交互关键技术研究，2014-2019，参与。

　　8. 国家自然科学基金面上项目（31871107），双眼竞争中人脑视皮层亚层特异的7T超高场功能磁共振成像，2019-2022，参与。

　　9. 国家自然科学基金面上项目（81871350），基于平衡式稳态自由进动的7T超高场高分辨率快速功能磁共振成像方法研究，2019-2022，参与。

　　10. 国家自然科学基金面上项目（81870833），基于多模态影像融合技术的颈动脉狭窄患者脑网络与认知功能研究，2019-2022，参与。

1. Sun, C. and Wu, Y., Ling, C., Xie, Z., Sun, Y., Xie, Z., Li, Z., Fang, X., Kong, Q., An, J., Wang, B., Zhuo Y., Zhang W., Wang Z., Yuan Y.^# and Zhang, Z.^#, 2021. Reduced Blood Flow Velocity in Lenticulostriate Arteries of Patients with CADASIL Assessed by PC-MRA at 7T. Journal of Neurology, Neurosurgery and Psychiatry, 93(4), pp.451-452. http://dx.doi.org/10.1136/jnnp-2021-326258

2. Kong, Q., Wu, Y., Weng, D., An, J., Zhuo, Y.^# and Zhang, Z.^#, 2021. Optimized Inner-Volume 3D TSE for High-Resolution Vessel Wall Imaging of Intracranial Perforating Arteries at 7T. Frontiers in Neuroscience, 15, p.66. https://doi.org/10.3389/fnins.2021.620172

3. Sun, C. and Wu, Y., Ling, C., Xie, Z., Kong, Q., Fang, X., An, J., Sun, Y., Zhang, W., Yang, Q., Wang, Z., Zhang, Z.^# and Yuan, Y.^#, 2020. Deep Gray Matter Iron Deposition and Its Relationship to Clinical Features in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Patients: A 7.0-T Magnetic Resonance Imaging Study. Stroke, 51(6), 1750-1757. https://doi.org/10.1161/STROKEAHA.119.028812

4. Zhang, Z. and Fan, Z., Kong, Q., Xiao, J., Wu, F., An, J., Yang, Q.^#, Li, D. and Zhuo, Y., 2019. Visualization of the lenticulostriate arteries at 3T using black-blood T1-weighted intracranial vessel wall imaging: comparison with 7T TOF-MRA. European radiology, 29(3), pp.1452-1459. https://doi.org/10.1007/s00330-018-5701-y

5. Ling, C. and Zhang, Z., Wu, Y., Fang, X., Kong, Q., Zhang, W., Wang, Z., Yang, Q.^# and Yuan, Y.^#, 2019. Reduced Venous Oxygen Saturation Associates With Increased Dependence of Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: A 7.0-T Magnetic Resonance Imaging Study. Stroke, 50(11), pp.3128-3134. https://doi.org/10.1161/STROKEAHA.119.026376

6. Huang, L., Zuo, Z., Bai, J., Zong, R., Zhou, J., Cui, Z., Wang, J, Chai, X., Wang, Z., An, J., Zhuo Y., Boada, F., Yu, X., Ling, Z., Qu, B., Pan, L.^# and Zhang, Z., 2021. Sodium MRI at 7T for Early Response Evaluation of Intracranial Tumors following Stereotactic Radiotherapy Using the CyberKnife. American Journal of Neuroradiology, 43(2), pp.181-187. https://doi.org/10.3174/ajnr.A7404

7. Feng, J., Liu, X., Zhang, Z.^#, Wu, Y., Li, Z., Zhang, Q., Jiang, Y., You, W., Liu, P., Wang, Y., Mossa-Basha, M., Saloner, D., Li, Y^#. and Zhu, C., 2021. Comparison of 7T and 3T vessel wall MRI for the evaluation of intracranial aneurysm wall. European Radiology, pp.1-9. https://doi.org/10.1007/s00330-021-08331-9

8. Wei, N., Zhang, X., An, J., Zhuo, Y. and Zhang, Z.^#, 2021. A processing pipeline for quantifying lenticulostriate artery vascular volume in subcortical nuclei. Frontiers in Neurology, p.1320. https://doi.org/10.3389/fneur.2021.700476

9. Liu, X., Feng, J., Li, Z., Zhang, Z.^#, Zhang, Q., Jiang, Y., Huo, X., Chai, X., Wu, Y., Kong, Q., Liu, P., Ge, H., Jin, H., An, J., Jiang, P., Saloner, D., Li, Y.^# and Zhu, C. 2021. Quantitative analysis of unruptured intracranial aneurysm wall thickness and enhancement using 7T high resolution, black blood magnetic resonance imaging. Journal of NeuroInterventional Surgery. http://doi.org/10.1136/neurintsurg-2021-017688

10. Wang, P., Cai, H., Luo, R., Zhang, Z., Zhang, D. and Zhang, Y.^#, 2021. Measurement of Cortical Atrophy and Its Correlation to Memory Impairment in Patients With Asymptomatic Carotid Artery Stenosis Based on VBM-DARTEL. Frontiers in Aging Neuroscience, p.304. https://doi.org/10.3389/fnagi.2021.620763

11. Sun, K., Cui, J., Xue, R., Jiang, T., Wang, B., Zhang, Z., Zhuo, Y., Zhou, X.J., Liang, S., Yu, X. and Chen, L., 2021. New imaging features of tuberous sclerosis complex: A 7 T MRI study. NMR in Biomedicine, 34(9), p.e4565. https://doi.org/10.1002/nbm.4565

12. Liu, X., Zhang, Z., Zhu, C., Feng, J., Liu, P., Kong, Q., Zhang, X., Zhang, Q., Jin, H., Ge, H., Jiang, Y., Saloner, D. and Li, Y.^#, 2020. Wall enhancement of intracranial saccular and fusiform aneurysms may differ in intensity and extension: a pilot study using 7-T high-resolution black-blood MRI. European Radiology, pp.1-7. https://doi.org/10.1007/s00330-019-06275-9

13. Qian, Y., Zou, J., Zhang, Z., An, J., Zuo, Z., Zhuo, Y., Wang, D.J. and Zhang, P., 2020. Robust functional mapping of layer-selective responses in human lateral geniculate nucleus with high-resolution 7T fMRI. Proceedings of the Royal Society B, 287(1925), p.20200245. https://doi.org/10.1098/rspb.2020.0245

14. Liu, C., Guo, F., Qian, C., Zhang, Z., Sun, K., Wang, D.J., He, S. and Zhang, P., 2020. Layer-dependent multiplicative effects of spatial attention on contrast responses in human early visual cortex. Progress in Neurobiology, p.101897. https://doi.org/10.1016/j.pneurobio.2020.101897

15. Kong, Q. and Zhang, Z.^#, Yang, Q., Fan, Z., Wang, B., An, J. and Zhuo, Y.^#, 2019. 7T TOF-MRA Shows Modulated Orifices of Lenticulostriate Arteries Associated with Atherosclerotic Plaques in Patients with Lacunar Infarcts. European Journal of Radiology, 118, pp.271-276. https://doi.org/10.1016/j.ejrad.2019.07.032

16. Ling, C. and Fang, X., Kong, Q., Sun, Y., Wang, B., Zhuo, Y., An, J., Zhang, W., Wang, Z., Zhang, Z.^# and Yuan, Y.^#, 2019. Lenticulostriate Arteries and Basal Ganglia Changes in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, A High-Field MRI study. Frontiers in Neurology, 10, p.870. https://doi.org/10.3389/fneur.2019.00870

17. Wei, N., Zhang, Z.^#, An, J., Weng, D. and Zhuo, Y., 2018. Improved visualization of superficial temporal artery using segmented time-of-flight MR angiography with venous suppression at 7T. Neuroradiology, 60(11), pp.1243-1246. https://doi.org/10.1007/s00234-018-2099-9

18. Cong, F., Wang, J.W., Wang, B., Yang, Z., An, J., Zuo, Z., Zhang, Z., Zhang, Y.Q.^# and Zhuo, Y.^#, 2018. Direct localisation of the human pedunculopontine nucleus using MRI: a coordinate and fibre-tracking study. European radiology, 28(9), pp.3882-3892. https://doi.org/10.1007/s00330-017-5299-5

19. Zhang, Z., Deng, X., Weng, D., An, J., Zuo, Z., Wang, B., Wei, N., Zhao, J. and Xue, R.^#, 2015. Segmented TOF at 7 T MRI: technique and clinical applications. Magnetic resonance imaging, 33(9), pp.1043-1050. https://doi.org/10.1016/j.mri.2015.07.002

20. Deng, X., Zhang, Z., Zhang, Y., Zhang, D., Wang, R., Ye, X., Xu, L., Wang, B., Wang, K. and Zhao, J.^#, 2016. Comparison of 7.0-and 3.0-T MRI and MRA in ischemic-type moyamoya disease: preliminary experience. Journal of neurosurgery, 124(6), pp.1716-1725. https://doi.org/10.3171/2015.5.JNS15767

21. Fang, X.J., Yu, M., Wu, Y., Zhang, Z.H., Wang, W.W., Wang, Z.X. and Yuan, Y.^#, 2017. Study of enhanced depth imaging optical coherence tomography in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Chinese medical journal, 130(9), p.1042. https://doi.org/10.4103/0366-6999.204935

22. Ma, Y.J., Liu, W., Zhao, X., Tang, W., Zhang, Z., Tang, X., Fan, Y., Li, H. and Gao, J.H.^#, 2015. Improved adaptive reconstruction of multichannel MR images. Medical physics, 42(2), pp.637-644. https://doi.org/10.1118/1.4905163

（资料来源：张紫豪高级工程师，2022-04-02）