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中科院青促会会员

何玲莉博士副研究员

中国科学院青年创新促进会会员
中国科学院生物物理研究所，生物大分子国家重点实验室

研究方向：膜蛋白的结构和功能研究

电子邮件：helingli@ibp.ac.cn

电话：010-64888514

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_zkyqchhy/202203/t20220322_339563.html

简历：

　　2004.09 - 2008.06 中国农业大学，生物科学类，理学学士

　　2008.09 - 2014.01 中国科学院大学，植物学，理学博士

　　2014.04 - 2021.12 中国科学院生物物理研究所，生物大分子国家重点实验室，助理研究员

　　2022.01 - 至今中国科学院生物物理研究所，生物大分子国家重点实验室，副研究员

获奖及荣誉：

社会任职：

研究方向：

　　1. 谷氨酸受体的结构和功能研究

　　2. 电压门控钙离子通道的结构和功能研究

　　3. 单分子荧光共振能量转移技术

承担项目情况：

代表论著：

1. Zhang, H.^#, Su, J.^#, Li, B.^#, Gao, Y., Liu, M., He, L., Xu, H., Dong, Y., Zhang, X. C., & Zhao, Y.* (2022). Structure of human glycosylphosphatidylinositol transamidase. Nature structural & molecular biology, 29(3), 203-209. https://doi.org/10.1038/s41594-022-00726-6.

2. He, L.^#, Sun, J.^#, Gao, Y.^#, Li, B., Wang, Y., Dong, Y., An, W., Li, H., Yang, B., Ge, Y., Zhang, X. C.*, Shi, Y. S.*, & Zhao, Y.* (2021). Kainate receptor modulation by NETO2. Nature, 599(7884), 325-329. https://doi.org/10.1038/s41586-021-03936-y.

3. Yang, W.^#, Wang, Y.^#, Guo, J.^#, He, L., Zhou, Y., Zheng, H., Liu, Z., Zhu, P.*, & Zhang, X. C.* (2020). Cryo-electron microscopy structure of CLHM1 ion channel from Caenorhabditis elegans. Protein science: a publication of the Protein Society, 29(8), 1803-1815. https://doi.org/10.1002/pro.3904.

4. Zhou, Y., Cao, C., He, L., Wang, X., & Zhang, X. C.* (2019). Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870. eLife, 8, e48822. https://doi.org/10.7554/eLife.48822.

5. Wang, Y.^#, Gao, H.^#, He, L.^#, Zhu, W., Yan, L., Chen, Q., & He, C.* (2019). The PHOSPHATE1 genes participate in salt and Pi signaling pathways and play adaptive roles during soybean evolution. BMC plant biology, 19(1), 353. https://doi.org/10.1186/s12870-019-1959-8.

6. Zhu, Y., He, L., Liu, Y., Zhao, Y., & Zhang, X. C.* (2019). smFRET Probing Reveals Substrate-Dependent Conformational Dynamics of E. coli Multidrug MdfA. Biophysical journal, 116(12), 2296-2303. https://doi.org/10.1016/j.bpj.2019.04.034.

7. Cao, C.^#, Tan, Q.^#, Xu, C., He, L., Yang, L., Zhou, Y., Zhou, Y., Qiao, A., Lu, M., Yi, C., Han, G. W., Wang, X., Li, X., Yang, H., Rao, Z., Jiang, H., Zhao, Y., Liu, J., Stevens, R. C., Zhao, Q., Zhang, X. C.*, Wu, B.* (2018). Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nature structural & molecular biology, 25(6), 488-495. https://doi.org/10.1038/s41594-018-0068-y.

8. Zhang, H., Qiao, A., Yang, L., Van Eps, N., Frederiksen, K. S., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Cao, C., He, L., Yang, H., Lau, J., Ernst, O. P., Hanson, M. A., Stevens, R. C., Wang, M. W., Reedtz-Runge, S., Jiang, H., Zhao, Q.*, Wu, B.* (2018). Structure of the glucagon receptor in complex with a glucagon analogue. Nature, 553(7686), 106-110. https://doi.org/10.1038/nature25153.

9. Zhao, M., Gu, Y., He, L., Chen, Q., & He, C.* (2015). Sequence and expression variations suggest an adaptive role for the DA1-like gene family in the evolution of soybeans. BMC plant biology, 15, 120. https://doi.org/10.1186/s12870-015-0519-0.

10. Wang, L., He, L., Li, J., Zhao, J., Li, Z., & He, C.* (2014). Regulatory change at Physalis Organ Size 1 correlates to natural variation in tomatillo reproductive organ size. Nature communications, 5, 4271. https://doi.org/10.1038/ncomms5271.

11. Zhao, M., He, L., Gu, Y., Wang, Y., Chen, Q., & He, C.* (2014). Genome-wide analyses of a plant-specific LIM-domain gene family implicate its evolutionary role in plant diversification. Genome biology and evolution, 6(4), 1000-1012. https://doi.org/10.1093/gbe/evu076.

12. He, L., Zhao, M., Wang, Y., Gai, J., & He, C.* (2013). Phylogeny, structural evolution and functional diversification of the plant PHOSPHATE1 gene family: a focus on Glycine max. BMC evolutionary biology, 13, 103. https://doi.org/10.1186/1471-2148-13-103.

（资料来源：何玲莉副研究员，2022-03-22）