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中科院青促会会员

冯菡博士副研究员

中国科学院青年创新促进会会员

研究方向：病原菌感染及宿主免疫应答

电子邮件：qingfengpa@163.com

电话：

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_zkyqchhy/202005/t20200519_339573.html

简历：

　　2006.09 - 2011.06 吉林大学，学士

　　2011.09 - 2016.06 中国科学院生物物理研究所，博士

　　2016.07 - 2019.12 中国科学院生物物理研究所，助理研究员

　　2020.01 - 至今中国科学院生物物理研究所，副研究员

获奖及荣誉：

社会任职：

研究方向：

　　利用结构生物学手段（X-ray 和冷冻电镜）并结合生物化学及细胞生物学等手段，探索感染与免疫相关的生物学问题，包括病原体感染及宿主免疫应答两个方面。

承担项目情况：

代表论著：

1. Feng Na^#, Feng Han^#, Wang Sheng, Avinash S. Punekar, Rudolf Ladenstein, Wang Da-Cheng, Zhang Qinghua*, Ding Jingjin* and Liu Wei*. Structures of heat shock factor trimers bound to DNA. iScience, 2021.9.24 :102951

2. Feng Han^#, Tian Huabin^#, Wang Yong, Zhang Qixiang, Lin Ni, Liu Songqing, Yu Yang, Deng Hongyu*, Gao Pu*. Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10. PNAS, 2020.10.27 117 (43) 26719-26727

3. Zhu Yalan^#; Gao Ang^#; Zhan Yi; Wang Yong; Feng Han; Liu Songqing; A. Serganov* and Gao Pu*. Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins. Molecular cell，2019.4.18 74(2): 296~309.

4. Wang Yong^#; Shi Miao; Feng Han; Zhu Yalan; Liu Songqing; Gao Ang*; Gao Pu*. Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE. Cell, 2018.5.17 173(5): 1231~1243.

5. Feng Han^#; Liu Xuehui; Wang Sheng; Fleming Joy; Wang Da-Cheng*; LiuWei*. The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. Nature Communications, 2017.12.21 8(2242).

6. Feng Han^#; Ding Jingjin^#; Zhu Deyu^#; Liu Xuehui; Xu Xueyong; Zhang Ying; Zang Shanshan; Wang Da-Cheng*; Liu Wei*. Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins. Journal of the American Chemical Society, 2014.10.22 136(42): 14694~14697.

7. Wang Yong^#; Feng Han^#; Zhu Yalan; Gao Pu(*).Structural insights into glutathione-mediated activation of the master regulator PrfA in Listeria monocytogenes. Protein & Cell, 2017.03.07 8: 308~312.

8. Feng Han^#; Wang Sheng^#; Guo Ling; Punekar Avinash S.; Ladenstein Rudolf; Wang Da-Cheng*; Liu Wei*. MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction. Protein & Cell, 2016.12 7(12) : 916~920.

9. Feng Han^#; Liu Wei; Wang Da-Cheng*. Purification crystallization and X-ray diffraction analysis of the DNA-binding domain of human heat-shock factor 2. Acta Crystallographica Section F-Structural Biology Communications, 2016.4 72 : 294~299.

（资料来源：冯涵副研究员，2021-12-29）