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中科院青促会会员

纪伟  博士 研究员 博士生导师  

中科院生物物理所,研究组长
中国科学院青年创新促进会会员
中国科学院关键技术人才

研究方向:单分子定位成像和检测技术

电子邮件:jiwei@ibp.ac.cn

电       话:010-64888846

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_zkyqchhy/202005/t20200519_339611.html

简       历:

  2001.09 - 2005.06  华中科技大学,生物医学工程学士

  2005.09 - 2010.06  中国科学院生物物理研究所,生物物理学博士

  2010.08 - 2011.12  中国科学院生物物理研究所,工程师

  2012.01 - 2016.12  中国科学院生物物理研究所,科学研究平台,高级工程师

  2017.01 - 2020.07  中国科学院生物物理研究所,科学研究平台,正高级工程师

  2020.07 - 至 今       中国科学院生物物理研究所,研究员,课题组组长

获奖及荣誉:

社会任职:

研究方向:

  主要方向是开发单分子定位成像和单分子检测技术:

  1. 利用干涉和冷冻成像新原理、新技术,把单分子定位成像的三维空间分辨率到分子尺度,并拓展其在生物大分子动态分析和纳米尺度细胞结构解析等生命科学研究中的应用;

  2. 发展基于单分子检测的检测方法,实现高灵敏、高通量的数字化免疫检测技术,拓展其在医学检测中的应用。

承担项目情况:

代表论著:

1. Lusheng Gu, Yuanyuan Li, Shuwen Zhang, Yanhong Xue, Weixing, DongLi, Tao Xu*, Wei Ji*. (2019) Molecular resolution imaging by repetitive optical selective exposure, Nature Methods, DOI:10.1038/s41592-019-0544-2.

2. Li Y, Xue Y, Xu X, Wang G, Liu Y, Wu H, Li W, Wang Y, Chen Z, Zhang W, Zhu Y, Ji W, Xu T, Liu L, Chen Q. (2018) A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. EMBO J. doi: 10.15252/embj.201798786. [Epub ahead of print] 

3. Xu X, Xue Y, Tian B, Feng F, Gu L, Li W, Ji W*, Xu T*.(2018) Ultra-stable super-resolution fluorescence cryo-microscopy for correlative light and electron cryo-microscopy. Sci China Life Sci. 61(11):1312-1319. doi: 10.1007/s11427-018-9380-3. Epub 2018 Nov 2.

4. Zou W, Fu J, Zhang H, Du K, Huang W, Yu J, Li S, Fan Y, Baylis HA, Gao S, Xiao R, Ji W*, Kang L*, Xu T*.(2018) Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron. Nat Commun. 9(1):4311. doi: 10.1038/s41467-018-06819-5.

5. Xi Lan#,Chunyan Fan#Wei Ji,Fuyun Tian,Tao Xu*,Zhaobing Gao*. (2016) Grafting voltage and pharmacological sensitivity in potassium channels. Cell Research  (2016) :1-11.

6. Liu B#, Xue Y#, Zhao W#, Chen Y, Fan C, Gu L, Zhang Y, Zhang X, Sun L, Huang X, Ding W, Sun F, Ji W*, Xu T*. (2015) Three-dimensional super-resolution protein localization correlated with vitrified cellular context. Sci Rep. (2015)5:13017.

7. Gu L#, Sheng Y#, Chen Y#, Chang H, Zhang Y, Lv P, Ji W*, Xu T*. (2014) High-density 3D single molecular analysis based on compressed sensing. Biophys J. 106(11):2443-9.

8. Zhang Y#, Gu L#, Chang H#, Ji W#, Chen Y, Zhang M, Yang L, Liu B, Chen L*, Xu T*. (2013) Ultrafast, accurate, and robust localization of anisotropic dipoles. Protein & Cell. 4(8): 598–606

9. Mingshu Zhang#, Hao Chang#, Yongdeng Zhang#, Junwei Yu, Lijie Wu, Wei Ji, Juanjuan Chen, Bei Liu, Jingze Lu, Yingfang Liu, Junlong Zhang, Pingyong Xu*, and Tao Xu*. (2012) Rational design of true monomeric and bright photoactivatable fluorescent proteins. Nature methods. doi:10.1038/nMeth.2021

10. Hao Chang#, Mingshu Zhang#, Wei Ji#, Juanjuan Chen, Yongdeng Zhang, Bei Liu, Jingze Lu, Junlong Zhang, Pingyong Xu*, and Tao Xu*. (2012) A unique series of reversibly switchable fluorescent proteins with beneficial properties for various applications. Proc Natl Acad Sci U S A. 109(12):4455-60.

11. Yu Chen#, Yan Wang#, Wei Ji#, Pingyong Xu* and Tao Xu*. (2008)A pre-docking role for microtubules in insulin-stimulated glucose transporter 4 translocation. FEBS J. 275(4):705-12

12. Wei Ji#, Pingyong Xu#, Zhengzheng Li#, Jingze Lu, Lin Liu, Yi Zhan, Yu Chen, BertilHille, Tao Xu*, and Liangyi Chen*. (2008) Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proc Natl Acad Sci USA. 105(36):13668-73.

(资料来源:纪伟研究员,2020-12-28)