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中科院青促会会员

柴谦（已调离）博士副研究员

中国科学院青年创新促进会会员

研究方向：免疫学及发育生物学

电子邮件：qianchai@ibp.ac.cn

电话：010-64880046

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_zkyqchhy/202005/t20200519_339598.html

简历：

　　2003.08 - 2007.06 山东大学生命科学学院理学学士

　　2007.08 - 2009.06 瑞典乌普萨拉大学理学硕士

　　2009.11 - 2013.11 瑞士苏黎世联邦高等工业学院(ETH) 理学博士

　　2013.12 - 2014.03 瑞士圣加伦州立医院免疫生物学研究所博士后

　　2014.06 - 2023.11 中国科学院生物物理研究所副研究员

获奖及荣誉：

社会任职：

研究方向：

　　主要从事免疫系统基质细胞微环境在淋巴器官和淋巴细胞发育与功能，以及在炎症反应等免疫应答过程中的作用与机制的研究：

　　1. 探索组织微环境对肠道天然淋巴细胞的发育、分化和功能的调控机制；

　　2. 发掘稳态以及炎症状态下，组织微环境与淋巴细胞交互对话的作用机制；

　　3. 探索慢性炎症反应中，淋巴器官纤维化的发生机制；

　　4. 探索基质细胞微环境在肿瘤转移过程中的相关功能与机制。

承担项目情况：

　　国家自然基金重大项目(81991493)，2020-2024年

　　国家自然基金面上项目(31970866)，2020-2023年

　　国家自然基金面上项目(81671537)，2017-2020年

　　国家重大科学研究计划青年科学家项目计划(973青年)(2015CB943400)，2015-2019年

　　国家自然基金青年基金(31400758)，2015-2017年

代表论著：

1. Pian YY^#, Chai Q^#*, Ren BY, Wang Y, Lv MJ, Qiu J, Zhu MZ*. Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LTβR Pathway during Listeria Infection. J Immunol. 2020 Aug 1, 205 (3) 853-863

2. Wang WJ, Zhou XX, Bian YJ, Wang S, Chai Q, Guo ZQ, Wang ZN, Zhu P, Peng H, Yan XY, Li WB, Fu YX, Zhu MZ*. Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B. Nature Nanotechnology. 2020, 15, 406-416

3. Wang Z, Wang W, Chai Q, Zhu M. Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LTβR Signaling. J Immunol. 2019 May 15; 202 (10):2999-3007.

4. Wang ZN^#, Chai Q^#*, Zhu MZ*. Differential Roles of LTβR in Endothelial Cell Subsets for Lymph Node Organogenesis and Maturation. J Immunol. 2018 July 1; 201 (1):69-76.

5. Chung J, Ebens CL, Perkey E, Radojcic V, Koch U, Scarpellino L, Tong A, Allen F, Wood S, Feng J, Friedman A, Granadier D, Tran IT, Chai Q, Onder L, Yan M, Reddy P, Blazar BR, Huang AY, Brennan TV, Bishop DK, Ludewig B, Siebel CW, Radtke F, Luther SA, Maillard I. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. J Clin Invest. 2017 Apr 3;127(4):1574-1588.

6. Wu W, Shi Y, Xia H, Chai Q, Jin C, Ren B, Zhu M. Epithelial LTβR signaling controls the population size of the progenitors of medullary thymic epithelial cells in neonatal mice. Sci Rep. 2017 Mar 14;7:44481.

7. Gil-Cruz C, Perez-Shibayama C, Onder L, Chai Q, Cupovic J, Cheng HW, Novkovic M, Lang P, Geuking M, McCoy K, Abe S, Cui GW, Ikuta K, Scandella E, Ludewig B. Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol. 2016 Oct.

8. Shi YY, Wu WW, Chai Q, Li QQ, Hou Y, Xia H, Ren BY, Xu HR, Guo XH, Jin CW, Lv MJ, Wang ZN, Fu YX& Zhu MZ. LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nat Commun. 2016 Aug.

9. Onder L, Nindl V, Scandella E, Chai Q, Cheng HW, Caviezel-Firner S, Novkovic M, Bomze D, Maier R, Mair F, Ledermann B, Becher B, Waisman A, Ludewig B. Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction. Eur J Immunol. 2015 Aug; 45(8):2218-31.

10. Fasnacht N, Huang HY, Koch U, Favre S, Auderset F, Chai Q, Onder L, Kallert S, Pinschewer DD, MacDonald HR, Tacchini-Cottier F, Ludewig B, Luther SA, Radtke F. Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. J Exp Med. 2014 Oct 20; 211(11):2265-79.

11. Perez-Shibayama C, Gil-Cruz C, Pastelin-Palacios R, Cervantes-Barragan L, Hisaki E, Chai Q, Onder L, Scandella E, Regen T, Waisman A, Isibasi A, Lopez-Macias C, Ludewig B. IFN-γ-producing CD4⁺ T cells promote generation of protective germinal center-derived IgM⁺ B cell memory against Salmonella Typhi. J Immunol. 2014 Jun 1; 192(11):5192-200.

12. Chai Q, Onder L, Scandella E, Gil-Cruz C, Perez-Shibayama C, Cupovic J, Danuser R, Sparwasser T, Luther SA, Thiel V, Rülicke T, Stein JV, Hehlgans T, Ludewig B. Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity. 2013 May 23; 38(5):1013-24.

13. Chai Q, Singh B, Peisker K, Metzendorf N, Ge X, Dasgupta S, Sanyal S. Organization of ribosomes and nucleoids in Escherichia coli cells during growth and in quiescence.J Biol Chem. 2014 Apr 18; 289(16):11342-52.

14. Onder L, Danuser R, Scandella E, Firner S, Chai Q, Hehlgans T, Stein J V, Ludewig B. Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation. J Exp Med. 2013 Mar 11; 210(3):465-73.

15. Onder L, Narang P, Scandella E, Chai Q, Iolyeva M, Hoorweg K, Halin C, Richie E, Kaye P, Westermann J, Cupedo T, Coles M, Ludewig B. IL-7-producing stromal cells are critical for lymph node remodeling. Blood. 2012 Dec 6; 120(24):4675-83.

16. Onder L, Scandella E, Chai Q, Firner S, Mayer C T, Sparwasser T, Thiel V, Rülicke T, Ludewig B. A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo. Front Immunol. 2011; 2:50.

（资料来源：柴谦副研究员，2020-12-28）