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中科院青促会会员

张维绮（已调离）博士研究员

国家“优秀青年基金”获得者 
入选中国科协“青年人才托举工程”
中国科学院青年创新促进会会员

研究方向：衰老的机制及调控

电子邮件：weiqizhang@aliyun.com

电话：010-64889970

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_zkyqchhy/202005/t20200519_339596.html

简历：

　　2001.09 – 2005.06 南昌大学，生命科学学院，学士

　　2005.09 – 2011.06 北京大学，生命科学学院，博士

　　2011.10 – 2015.10 中国科学院生物物理研究所，生物大分子国家重点实验室，助理研究员

　　2015.10 – 2016.12 中国科学院生物物理研究所，生物大分子国家重点实验室，副研究员

　　2016.12 – 2019 中国科学院生物物理研究所，生物大分子国家重点实验室，研究员

　　（获中国科学院生物物理研究所“项目研究员计划”支持）

获奖及荣誉：

社会任职：

　　中国细胞生物学会衰老细胞生物学分会委员

　　中国老年学和老年医学学会抗衰老分会委员

研究方向：

　　衰老的细胞分子机制及调控：利用干细胞、模式生物、基因编辑、基因组范围筛选和多层次组学揭示衰老发生发展的关键信号调控网络，发现和鉴定未知的延缓衰老进程的分子靶标。

承担项目情况：

代表论著：

1. Zhang W*, Wan H*, Feng G*, Qu J*, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W, Liu G-H and Hu B. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018;560:661-665.(*equal contribution)

2. Zhang W*, Li J*, Suzuki K*, Qu J*, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu G-H and Belmonte JCI. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015;348:1160.(*equal contribution)

3. Kubben N, Zhang W^#, Wang L, Voss TC, Yang J, Qu J^#, Liu G-H and Misteli T. Repression of the Antioxidant NRF2 Pathway in Premature Aging. Cell. 2016;165:1361-1374.(^#Cosenior author)

4. Zhang W*, Song M*, Qu J and Liu G-H. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018;123:773-786. (*equal contribution)

5. Zhang W, Qu J, Suzuki K, Liu G-H and Belmonte JCI. Concealing cellular defects in pluripotent stem cells. Trends in Cell Biology. 2013;23:587-592.

6. Geng L*, Liu Z*, Zhang W^#, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L, Ju Z, Chan P, Song M^#, Qu J^# and Liu G-H^#. Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein & Cell. 2018. (^#Corresponding author)

7. Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu G-H^#, Zhang W^#, Song M^# and Qu J^#. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein & Cell. 2018.(#Corresponding author)

8. Li Y*, Zhang W*, Chang L, Han Y, Sun L, Gong X, Tang H, Liu Z, Deng H, Ye Y, Wang Y, Li J, Qiao J, Qu J, Zhang W and Liu G-H. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein & Cell. 2016;7:478-488. (*equal contribution)

9. Wu Z*, Zhang W*, Song M*, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J, Suzuki K, Belmonte JCI and Liu G-H. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein & Cell. 2018;9:333-350. (*equal contribution)

10. Guan D*, Zhang W*, Zhang W, Liu GH and Belmonte JCI. Switching cell fate, ncRNAs coming to play. Cell Death & Disease. 2013;4:e464. (*equal contribution)

11. Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M and Deng H. Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation. Cell Stem Cell. 2008;3:475-479.

12. Yang J*, Zhang W*, Jiang W, Sun X, Han Y, Ding M, Shi Y and Deng H. P21cip-Overexpression in the Mouse β Cells Leads to the Improved Recovery from Streptozotocin-Induced Diabetes. PLOS ONE. 2009;4:e8344. (*equal contribution

13. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Izpisua Belmonte JC, Qu J, Tang F and Liu G-H. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Research. 2017;27:1178.

14. Tong Z, Fan Y, Zhang W, Xu J, Cheng J, Ding M and Deng H. Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling. Cell Research. 2009;19:710.

15. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T, Qu J and Liu G-H. Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Research. 2017;27:483.

16. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J, Tang F and Liu G-H. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Research. 2016;26:190.

17. Liu G-H, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla RD, Goebl A, Aizawa E, Kim NY, Kim J, Dubova I, Li Y, Ren R, Benner C, del Sol A, Bueren J, Trujillo JP, Surralles J, Cappelli E, Dufour C, Esteban CR and Belmonte JCI. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. Nature Communications. 2014;5:4330.

18. Liu G-H, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Wagner U, Kim A, Ren B, Li Y, Goebl A, Kim J, Soligalla RD, Dubova I, Thompson J, Iii JY, Esteban CR, Sancho-Martinez I and Belmonte JCI. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature. 2012;491:603.

19. Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y and Deng H. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Research. 2010;21:196.

20. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Belmonte JCI, Chen Z, Wang X, Jiang T, Qu J, Tang F and Liu G-H. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nature Communications. 2015;6:10068.

21. Zhang W*, Guan D*, Qu J, Zhang W and Liu G-H. Non-viral iPSCs: a safe way for therapy? Protein & Cell. 2012;3:241-245. (*equal contribution)

22. Zhang W*, Duan S*, Li Y, Xu X, Qu J, Zhang W and Liu G-H. Converted neural cells: induced to a cure? Protein & Cell. 2012;3:91-97. (*equal contribution)

23. Zhang W*, Ding Z* and Liu G-H. Evolution of iPSC disease models. Protein & Cell. 2012;3:1-4. (*equal contribution)

24. Xu X, Yang J, Fu L, Ren R, Yi F, Suzuki K, Liu K, Ding Z, Qu J, Zhang W, Li Y, Yuan T, Yuan G, Sui L, Guan D, Duan S, Pan H, Wang P, Zhu X, Montserrat N, Li M, Bai R, Liu L, Izpisua Belmonte JC and Liu G-H. Direct reprogramming of porcine fibroblasts to neural progenitor cells. Protein & Cell. 2014;5:4-7.

25. Wang S, Liu Z, Ye Y, Li B, Liu T, Zhang W, Liu G-H, Zhang YA, Qu J, Xu D and Chen Z. Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model. Cell Death & Disease. 2018;9:923.

26. Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J, Tang F and Liu G-H. ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells. Cell Discovery. 2018;4:2.

27. Wang P*, Zhang W*, Yang J, Qu J and Liu G-H. Higher-order genomic organization in pluripotent stem cells. Protein & Cell. 2012;3:483-486. (*equal contribution)

28. Pan H*, Zhang W*, Zhang W and Liu G-H. Find and replace: editing human genome in pluripotent stem cells. Protein & Cell. 2011;2:950-956. (*equal contribution)

29. Fu L, Xu X, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Belmonte JCI, Qu J and Liu G-H. Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs. Protein & Cell. 2016;7:210-221.

30. Ding Z, Sui L, Ren R, Liu Y, Xu X, Fu L, Bai R, Yuan T, Hao Y, Zhang W, Pan H, Liu W, Yu H, Esteban CR, Yu X, Yang Z, Li J, Wang X, Belmonte JCI, Liu G-H, Yi F and Qu J. A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells. Protein & Cell. 2015;6:386-389.

（资料来源：张维绮研究员，2018-09-29）