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中科院青促会会员

魏艳博士副研究员

中国科学院青年创新促进会会员
中科院生物物理所，脑与认知科学国家重点实验室

研究方向：蛋白质异常修饰与代谢性疾病

电子邮件：yanwei@ibp.ac.cn

电话：010-64888531

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_zkyqchhy/202005/t20200519_339594.html

简历：

　　2000.09 - 2005.06 北京大学护理学院，医学学士

　　2005.09 - 2010.06 中国科学院生物物理研究所，理学博士

　　2010.07 - 2014.12 中国科学院生物物理研究所，助理研究员

　　2014.07 - 2014.10 澳大利亚昆士兰大学脑研究所，访问学者

　　2015.08 - 2016.08 澳大利亚昆士兰大学脑研究所，国家公派访问学者

　　2015.01 - 至今中国科学院生物物理研究所，副研究员

获奖及荣誉：

社会任职：

研究方向：

　　从分子、细胞、动物水平研究蛋白质异常修饰（磷酸化、糖基化等）的促发因素、错误折叠以及与代谢性疾病的关系。

承担项目情况：

　　1. 国家自然科学基金面上项目《核糖代谢异常在糖尿病脑病中的作用及机制研究》，2017-2020，直接经费60万，负责人

　　2. 国家青年科学基金项目《核糖糖基化导致Tau蛋白超磷酸化的分子机制研究》，2013-2015，23万，负责人

代表论著：

1. Mou LX, Hu PD, Cao X, Chen Y, Xu Y, He T, Wei Y^#, He RQ^#. Comparison of bovine serum albumin glycation by ribose and fructose in vitro and in vivo. BBA Mol Basis Dis, 2022, 1868(1):166283. (^#co-corresponding authors)

2. Li T*, Wei Y*, Qu M, Mou L, Miao J, Xi M, Liu Y, He R. Formaldehyde and de/methylation in age-related cognitive impairment. Genes, 2021, 12(6): 913. (* co-first authors)

3. Yu LX, Chen Y, Xu Y, He T, Wei Y^#, He RQ^#. D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. Aging (Albany NY), 2019, 11(14):4943-4969. (^#co-corresponding authors)

4. Wu BB, Wang YJ, Shi CG, Chen Y, Yu LX, Li J, Li WW, Wei Y^#, He RQ^#. Ribosylation-Derived Advanced Glycation End Products Induce Tau Hyperphosphorylation Through Brain-Derived Neurotrophic Factor Reduction. J Alzheimers Dis, 2019, 71(1):291-305.

5. Wu BB, Yu LX, Hu PD, Lu Y, Li J, Wei Y^#, He RQ^#. GRP78 protects CHO cells from ribosylation. BBA-Mol Cell Res, 2018, 1865:629-637. (^#co-corresponding authors)

6. Chen XX, Su T, Chen Y, He YG, Liu Y, Xu Y, Wei Y^#, Li J, He RQ^#. D-Ribose as a Contributor to Glycated Haemoglobin. Ebiomedicine, 2017, 25:143-153. (^#co-corresponding authors)

7. Hatch RJ, Wei Y, Xia D, Goetz J. Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta Neuropathol, 2017, 133(5):717-730.

8. Li T, Su T, He YG, Lu JH, Mo WC, Wei Y^#, He RQ^#. Brain formaldehyde is related to water intake behavior. Aging Dis, 2016, 10.14336/AD.2016.0323. ( ^#co-corresponding authors)

9. Wei Y*, Wang YJ*, Wu BB, Zhang YH, He RQ. Ribosylated BSA monomer is severely toxic to SH-SY5Y cells. Prog Biochem Biophys, 2016, 43(6):579-591. (* co-first authors)

10. Wu BB*, Wei Y*, Wang YJ, Su T, Zhou L, Liu Y, He RQ. Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice. Oncotarget, 2015, 6(33):34128-42. (* co-first authors)

11. Wei Y, Han CS, Wang YJ, Wu BB, Su T, Liu Y, He RQ. Ribosylation triggering Alzheimer’s disease-like Tau hyperphosphorylation via activation of CaMKII. Aging Cell, 2015, 14(5):754-763.

12. Han CS, Lu Y, Wei Y^#, Wu BB, Liu Y, He RQ^#. D-Ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation. Cell Death Dis, 2014, 5, e1117. ( ^#co-corresponding authors)

13. Lu Y, He HJ, Zhou J, Miao JY, Lu J, He YG, Pan R, Wei Y^#, Liu Y, He RQ^#. Hyperphosphorylation results in tau dysfunction in DNA folding and protection. J Alzheimers Dis, 2013, 37:551-563. ( ^#co-corresponding authors)

14. Wei Y, Han CS, Zhou J, Liu Y, Chen L, He RQ. D-ribose in glycation and protein aggregation. Biochim Biophys Acta, 2012, 1820(4):488-494.

15. Liu YY, Qiang M, Wei Y, He RQ. A novel molecular mechanism for nitrated alpha-synuclein-induced cell death. J Mol Cell Biol, 2011, 3:239–249.

16. Chen L*, Wei Y*, Wang XQ, He RQ. Ribosylation rapidly induces a-synuclein to form highly cytotoxic molten globules of advanced glycation end products. PLoS ONE, 2010, 5(2):e9052. (* co-first authors)

17. Wei Y*, Chen L*, Chen J, Ge L, He RQ. Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells. BMC Cell Biol, 2009, 10:10. (* co-first authors)

18. Wei Y*, Qu MH*, Wang SX, Chen L, Wang DL, Liu Y, Hua Q, He RQ. Binding to the Minor Groove of the Double-Strand, Tau Protein Prevents DNA from Damage by Peroxidation. PLoS ONE, 2008, 3(7): e2600. (* co-first authors)

（资料来源：魏艳副研究员，2021-11-02）