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姓氏首字母L

刘超培博士研究员博士生导师

中科院生物物理所，表观遗传调控与干预重点实验室，研究组长
中国科学院青年创新促进会会员

研究方向：染色质组装与调控的结构生物学

电子邮件：liuchaopei@ibp.ac.cn

电话：010-64888390

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_xsszmL/202402/t20240222_657437.html

简历：

2001 - 2005 湖南师范大学物理学学士

2005 - 2010 中国科学院高能物理研究所博士

2010 - 2013 中国科学院生物物理研究所博士后

2013 - 2021 中国科学院生物物理研究所副研究员

2022 - 2023 中国科学院生物物理研究所研究员

2024 - 至今中国科学院生物物理研究所研究员，课题组长

获奖及荣誉：

社会任职：

研究方向：

本研究组主要从事染色质组装与调控的结构生物学研究，具体分两个方面：

1. DNA复制偶联的染色质组装机理

伴随DNA复制的染色质组装是真核生物细胞继承与可塑性的核心机制，涉及复制机器与组蛋白伴侣、修饰酶等表观遗传因子之间复杂而精密地联动。解析复制偶联关键蛋白复合体的结构与功能，将为理解染色质复制过程中表观遗传信息的继承提供重要认知，并为探索抗肿瘤新策略提供结构框架。

2. 减数分裂同源染色体联会的分子机理

减数分裂联会复合体与程序性DNA双链断裂（DSB）的产生和修复之间相互调控，确保同源染色体正确的识别、配对、重组和分离，以实现遗传物质在生物世代间的稳定传递和生物的遗传多样性。解析减数分裂重组调控的分子基础，将为生殖健康的精准治疗提供重要的结构参考。

承担项目情况：

代表论著：

1. Chao-Pei Liu^#*, Zhenyu Yu^#, Jun Xiong^#, Jie Hu^#, Aoqun Song^#, Dongbo Ding^#, Cong Yu, Na Yang, Mingzhu Wang, Juan Yu, Peini Hou, Kangning Zeng, Zhenyu Li, Zhuqiang Zhang, Xinzheng Zhang, Wei Li, Zhiguo Zhang, Bing Zhu*, Guohong Li*, and Rui-Ming Xu*. Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 2023, 381(6660): eadd8673.

2. Weiran Ge^#, Cong Yu^#, Jingjing Li^#, Zhenyu Yu, Xiaorong Li, Yan Zhang, Chao-Pei Liu, Yingfeng Li, Changlin Tian, Xinzheng Zhang, Guohong Li, Bing Zhu*, and Rui-Ming Xu*. Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase. Nature, 2023, 616(7955):176-182.

3. Ye Yue^#, Wen-Si Yang^#, Lin Zhang, Chao-Pei Liu, and Rui-Ming Xu. Topography of histone H3-H4 interaction with the Hat1-Hat2 acetyltransferase complex. Genes & Development, 2022, 36(7-8):408-413.

4. Hui Wang^#, Boyuan Li^#, Linyu Zuo, Bo Wang, Yan Yan, Kai Tian, Rong Zhou, Chenlu Wang, Xizi Chen, Yongpeng Jiang, Haonan Zheng, Fangfei Qin, Bin Zhang, Yang Yu, Chao-Pei Liu, Yanhui Xu, Juntao Gao, Zhi Qi, Wulan Deng, and Xiong Ji. The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors. Nature Communications, 2022, 13(1):5703.

5. Jing Zhang^#, Yan Zhang^#, Qinglong You^#, Chang Huang, Tiantian Zhang, Mingzhu Wang, Tianwei Zhang, Xiaocheng Yang, Jun Xiong, Yingfeng Li, Chao-Pei Liu, Zhuqiang Zhang, Rui-Ming Xu*, and Bing Zhu*. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science, 2022, 375(6584):1053-1058.

6. Chao-Pei Liu^#*, Wenxing Jin^#, Jie Hu, Mingzhu Wang, Jingjing Chen, Guohong Li, and Rui-Ming Xu*. Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes & Development, 2021, 35(23-24):1610-1624.

7. Wenxing Jin^#, Jia Wang^#, Chao-Pei Liu, Hong-Wei Wang*, and Rui-Ming Xu*. Structural Basis for pri-miRNA Recognition by Drosha. Molecular Cell, 2020, 78(3):423-433.e5.

8. Peini Hou^#, Chang Huang^#, Chao-Pei Liu, Na Yang, Tianshu Yu, Yuxin Yin, Bing Zhu*, and Rui-Ming Xu*. Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding. Structure, 2019, 27(5):837-845.e3.

9. Chaoyang Xiong^#, Zengqi Wen^#, Juan Yu, Jun Chen, Chao-Pei Liu, Xiaodong Zhang, Ping Chen, Rui-Ming Xu, and Guohong Li. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells. BMC Biology, 2018, 16(1):110.

10. Wenxing Jin^#, Yi Wang^#, Chao-Pei Liu^#, Na Yang, Mingliang Jin, Yao Cong, Mingzhu Wang* and Rui-Ming Xu*. Structural basis for snRNA recognition by the double WD40-repeat domain of Gemin5. Genes & Development, 2016, 30(21): 2391-2403.

11. Chao-Pei Liu^#, Chaoyang Xiong^#, Mingzhu Wang, Zhouliang Yu, Na Yang,Ping Chen, Zhiguo Zhang, Guohong Li* and Rui-Ming Xu*. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nature Structural & Molecular Biology, 2012, 19(12): 1287-1292.

（资料来源：刘超培研究员，2024-02-22）