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生物大分子重点实验室

高利增博士研究员博士生导师

基础前沿课题组长，中国生物物理学会理事
中国生物物理学会纳米酶分会副会长
中国科学院生物物理研究所，生物大分子重点实验室，中国科学院纳米酶工程实验室

研究方向：纳米酶学，铁硫生物活性材料，仿生抗菌新策略

电子邮件：gaolizeng@ibp.ac.cn

电话：010-64888534

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_xsszmA_G/202005/t20200519_341413.html

简历：

1996.09 - 2000.07 吉林大学，生物化学，理学学士

2000.09 - 2003.07 吉林大学，生物化学，理学硕士

2003.09 - 2006.07 中国科学院生物物理研究所，生物化学与分子生物学，理学博士

2006.09 - 2010.01 美国匹兹堡大学，石油与化学工程系，博士后

2010.01 - 2013.11 美国康奈尔大学，Baker Institute for Animal Health, 博士后

2013.12 - 2015.07 美国宾夕法尼亚大学，School of Dental Medicine, 博士后

2015.08 - 2019.08 扬州大学，医学院/转化医学研究院，江苏特聘教授

2019.09 - 至今中国科学院生物物理研究所，纳米酶工程实验室，研究员/研究组长

获奖及荣誉：

2023年泰山产业创新领军人才

2017年江苏双创个人项目

2016年国家海外高层次人才青年项目

2015年江苏特聘教授

2015年国际牙医协会口腔护理创新奖

2010年北京市科学技术奖一等奖（第二）

社会任职：

研究方向：

聚焦纳米酶仿生设计及新特性的探索，发现铁硫纳米酶具有多种独特的生物学活性，基于纳米酶建立仿生抗菌新策略，并推动转化应用。

1. 纳米酶的理性设计和特性拓展。首次报道了四氧化三铁过氧化物纳米酶后，仿照天然酶活性中心结构理性设计纳米酶，提高催化活性超越天然酶，发现纳米酶的多酶活性和低温催化特性，提出纳米酶过氧化物酶体，人工模拟亚细胞器复杂功能；发现Aβ蛋白聚集体是一种天然纳米酶，不仅与AD的发生相关，还将生物催化体系从蛋白酶、核酶拓展到纳米酶。

2. 铁硫生物活性材料。发现纳米铁硫材料（FeS₂， Fe₃S₄， Fe₇S₈， FeS等晶体或MOF类结构）能够模拟铁硫簇功能，具有多种氧化还原酶类活性，其中亚稳态硫化铁还能够响应性释放亚铁-多硫活性物质，不仅调控氧化还原代谢、铁死亡，还能通过多硫化修饰影响蛋白功能，在抗肿瘤、抗菌、抗病毒、抗氧化方面具有潜在的应用价值。

3. 纳米酶仿生抗菌新策略。提出基于纳米酶人工模拟免疫细胞溶酶体多酶协同杀菌原理，快速、高效清除多种耐药菌、生物膜（Biofilm）和胞内菌，发现并阐明其介导的细菌铁死亡机制，并将这一杀菌机制拓展到病毒和真菌，在此基础上提出纳米酶抗生素（Nanozybiotics）新概念，在口腔龋齿、表皮伤口、肺炎、肠炎、胆囊炎、附睾炎、阴道炎、败血症等多种感染模型中验证了显著的防治效果。

4. 纳米酶转化应用。在口腔龋病、细菌性阴道炎防治方面开展临床相关研究，专利转让宝洁等公司；建立纳米酶小试-中试-放大生产工艺，生产规模达到吨级，，同时作为骨干共同制定多项纳米酶相关国家标准和国际ISO标准，为纳米酶产业转化奠定基础。

承担项目情况：

代表论著：

（*为通讯作者，#为第一作者）

1. Tao Qin, Yulian Chen, Xinyu Miao, Mengjuan Shao, Nuo Xu, Chunxiao Mou, Zhenhai Chen, Yuncong Yin, Sujuan Chen, Yinyan Yin*, Lizeng Gao*, Daxin Peng*, Xiufan Liu. Low‐Temperature Adaptive Single‐Atom Iron Nanozymes against Viruses in the Cold Chain. Advanced Materials 2024, 2309669

2. Beibei Li, Ruonan Ma, Lei Chen, Caiyu Zhou, Yu-Xiao Zhang, Xiaonan Wang, Helai Huang, Qikun Hu, Xiaobo Zheng, Jiarui Yang, Mengjuan Shao, Pengfei Hao, Yanfen Wu, Yizhen Che, Chang Li, Tao Qin, Lizeng Gao*, Zhiqiang Niu*, Yadong Li. Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus. Nature Communications 2023, 14 (1), 7312.

3. Zhuobin Xu, Yufei Zhu, Mengke Xie, Kankan Liu, Liangliang Cai, Huihui Wang, Dandan Li*, Hao Chen*, Lizeng Gao*. Mackinawite nanozymes as reactive oxygen species scavengers for acute kidney injury alleviation. Journal of Nanobiotechnology 2023, 21 (1), 1-17.

4. Ye Yuan, Lei Chen, Lingfei Kong, Lingling Qiu, Zhendong Fu, Minmin Sun, Yuan Liu, Miaomiao Cheng, Saiyu Ma, Xiaonan Wang, Changhui Zhao, Jing Jiang, Xinzheng Zhang, Liping Wang*, Lizeng Gao*. Histidine modulates amyloid-like assembly of peptide nanomaterials and confers enzyme-like activity. Nature Communications 2023, 14 (1), 5808.

5. Xiaonan Wang, Ting Liu, Mengxia Chen, Qian Liang, Jing Jiang, Lei Chen, Kelong Fan, Jinhua Zhang*, Lizeng Gao*. An Erythrocyte-Templated Iron Single-Atom Nanozyme for Wound Healing. Advanced Science 2023, 2307844.

6. Xinyu Miao, Yinyan Yin, Yulian Chen, Wenhui Bi, Yuncong Yin, Sujuan Chen, Daxin Peng*, Lizeng Gao*, Tao Qin*, Xiufan Liu. Bidirectionally Regulating Viral and Cellular Ferroptosis with Metastable Iron Sulfide Against Influenza Virus. Advanced Science 2023, 2206869.

7. Huizhen Fan, Jiajia Zheng, Jiaying Xie, Juewen Liu, Xingfa Gao, Xiyun Yan, Kelong Fan, Lizeng Gao*. Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay. Advanced Materials 2023, 2300387.

8. Haolin Cao, Qian Wang, Xiaonan Wang, Lei Chen, Jing Jiang, and Lizeng Gao*. Metastable Iron Sulfides: A Versatile Antibacterial Candidate with Multiple Mechanisms against Bacterial Resistance. Accounts of Materials Research 2023, 4 (2), 115-132.

9. Yao Chen, Qing Tian, Haoyu Wang, Ruonan Ma, Ruiting Han, Yu Wang, Huibin Ge, Yujing Ren, Rong Yang, Huimin Yang, Yinjuan Chen, Xuezhi Duan, Lianbing Zhang*, Jie Gao*, Lizeng Gao*, Xiyun Yan, Yong Qin*. A Manganese‐Based Metal-Organic Framework as a Cold‐Adapted Nanozyme. Advanced Materials 2022, 2206421.

10. Ruonan Ma, Ling Fang, Lei Chen, Xiaonan Wang, Jing Jiang, Lizeng Gao*. Ferroptotic stress promotes macrophages against intracellular bacteria. Theranostics, 2022, 12(5): 2266-2289.

11. Caiyu Zhou, Qian Wang, Jing Jiang, Lizeng Gao*. Nanozybiotics: Nanozyme-Based Antibacterials against Bacterial Resistance. Antibiotics, 2022, 11 (3): 390.

12. Ling Fang, Ruonan Ma, Xuejiao J Gao, Lei Chen, Yuan Liu, Yanwu Huo, Taotao Wei, Xiaonan Wang, Qian Wang, Haojue Wang, Chengjun Cui, Qifeng Shi, Jing Jiang, Lizeng Gao*. Metastable Iron Sulfides Gram-Dependently Counteract Resistant Gardnerella Vaginalis for Bacterial Vaginosis Treatment. Advanced Science, 2022, 2104341.

13. Xiangqin Meng, Dandan Li, Lei Chen, Helen He, Qian Wang, Chaoyi Hong, Jiuyang He, Xingfa Gao, Yili Yang, Bing Jiang, Guohui Nie, Xiyun Yan*, Lizeng Gao*, Kelong Fan*. High-performance self-cascade pyrite nanozymes for apoptosis-ferroptosis synergistic tumor therapy. ACS nano, 2021, 15 (3): 5735-5751.

14. Juqun Xi, Ruofei Zhang, Liming Wang, Wei Xu, Qian Liang, Jingyun Li, Jian Jiang, Yili Yang, Xiyun Yan*, Kelong Fan*, Lizeng Gao*. A nanozyme-based artificial peroxisome ameliorates hyperuricemia and ischemic stroke. Advanced Functional Materials, 2021, 31 (9): 2007130.

15. 高利增^#, 梁敏敏^#, 温涛^#, 魏辉, 张宇, 范克龙, 江冰, 曲晓刚, 顾宁, 庞代文, 许海燕*, 阎锡蕴*. 纳米酶标准术语. 中国科技术语, 2020, 22 (6): 21-24.

16. Xinyu Shen, Ruonan Ma, Yixin Huang, Lei Chen, Zhuobin Xu, Dandan Li, Xiangqin Meng, Kelong Fan, Juqun Xi, Xiyun Yan, Hyun Koo, Yili Yang, Jing Jiang, Lizeng Gao*. Nano-decocted ferrous polysulfide coordinates ferroptosis-like death in bacteria for anti-infection therapy. Nano Today, 2020, 35: 100981.

17. Tao Qin, Shang Ma, Xinyu Miao, Yan Tang, Dandan Huangfu, Jinyuan Wang, Jing Jiang, Nuo Xu, Yuncong Yin, Sujuan Chen, Xiufan Liu, Yinyan Yin*, Daxin Peng*, Lizeng Gao*. Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant. Advanced Science, 2020, 7 (18): 2000771.

18. Tao Qin^#, Ruonan Ma^#, Yinyan Yin, Xinyu Miao, Sujuan Chen, Kelong Fan, Juqun Xi, Qi Liu, Yunhao Gu, Yuncong Yin, Jiao Hu, Xiufan Liu, Daxin Peng*, Lizeng Gao*. Catalytic inactivation of influenza virus by iron oxide nanozyme. Theranostics, 2019; 9(23): 6920-6935.

19. Shourong Shi*, Shu Wu, Yiru Shen, Shan Zhang, Yunqi Xiao, Xi He, Jiansen Gong, Yuhua Farnell, Yan Tang, Yixin Huang, Lizeng Gao*. Iron oxide nanozyme suppresses intracellular Salmonella enteritidis growth and alleviates infection in vivo. Theranostics, 2018; 8(22): 6149-6162.

20. Zhuobin Xu, Zhiyue Qiu, Qi Liu, Yixin Huang, Dandan Li, Xinggui Shen, Kelong Fan, Juqun Xi, Yunhao Gu, Yan Tang, Jing Jiang, Jialei Xu, Jinzhi He, Xingfa Gao, Yuan Liu, Hyun Koo, Xiyun Yan and Lizeng Gao*. Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections. Nature Communications, 2018, 9: 3713.

21. Kelong Fan, Juqun Xi, Lei Fan, Peixia Wang, Chunhua Zhu, Yan Tang, Xiangdong Xu, Minmin Liang, Bing Jiang, Xiyun Yan*, Lizeng Gao*. In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy. Nature communications, 2018, 9 (1): 1440.

22. Lizeng Gao*, Yuan Liu, Dongyeop Kim, Yong Li, Geelsu Hwang, Pratap C. Naha, David P. Cormode, Hyun Koo*. Nanocatalysts promote Streptococcus mutans biofilm matrix degradation and enhance bacterial killing to suppress dental caries in vivo. Biomaterials, 2016, 101: 272-284.

23. Lizeng Gao^#, Jie Zhuang^#, Leng Nie, Jinbin Zhang, Yu Zhang, Ning Gu, Taihong Wang, Jing Feng, Dongling Yang, Sarah Perrett*, Xiyun Yan*. Intrinsic Peroxidase-like Activity of Ferromagnetic Nanoparticles. Nature Nanotechnology, 2007, 2 (9): 577-583.

（资料来源：高利增研究员，2024-04-01）