生物大分子重点实验室

　　1989 - 1993 华中科技大学化学系，学士

　　1993 - 1996 湖北省化学研究所，硕士

　　1996 - 1999 中国科学院生物物理研究所，博士

　　1999 - 2001 中国科学院生物物理研究所，助理研究员

　　2001 - 2008 中国科学院生物物理研究所，副研究员

　　2008 - 至今 中国科学院生物物理研究所，研究员

　　2019年，《细胞生物学》课程被评为中国科学院大学生命科学学院精品课程

　　2020年，《细胞生物学》课程被认定为国家一流本科课程

　　2021年，中国科学院大学领雁金奖——引航奖

　　2021年，江西省自然科学二等奖

培养研究生获奖情况：

　　2011年，赵凯，中国科学院三好学生标兵

　　2013年，周合江，国家奖学金

　　2014年，周合江，保罗生物科技奖学金

　　2016年，杜康，国家奖学金

　　2018年，贺小龙，所长奖学金

　　2018年，胡昊，所长奖学金

　　2020年，赵军程，唐立新奖学金

　　2020年，张佳龄，所长奖学金

　　2020年，李洪宇，所长奖学金

　　2020年，张叶，中国科学院大学大学生奖学金

　　线粒体是细胞的能量代谢中心，也是细胞命运决定的调控中枢之一。在正常生理条件下，线粒体网络不断发生动态变化、实现稳态维持，通过进行能量代谢与物质代谢维持细胞生命活动；在特定病理条件下，线粒体稳态被破坏，直接影响线粒体的功能，对生命过程造成显著影响。本课题组结合结构生物学、单分子生物物理学、蛋白组学及修饰组学等技术手段发现了多种维持线粒体稳态的蛋白质机器，解析了它们影响细胞命运决定的分子机制，并揭示了它们参与代谢性疾病及恶性肿瘤发生发展的重要作用；还构建了一系列靶向线粒体、调控细胞能量代谢并有效阻遏肿瘤的纳米生物材料。

1. Boda Zhou, Min Xiao, Hao Hu, Xiaoxia Pei, Yajun Xue, Guobin Miao, Jifeng Wang, Wanqi Li, Yipeng Du, Ping Zhang* and Taotao Wei*. Cardioprotective role of SIRT5 in response to acute ischemia through a novel liver-cardiac crosstalk mechanism. Frontiers in Cell and Developmental Biology. 9(2021), 687559.

2. Jialing Zhang, Liang Yan, Peng Wei, Ruyi Zhou, Chaoju Hua, Min Xiao, Yaping Tu, Zhanjun Gu and Taotao Wei*. PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition. European Journal of Pharmacology, 895(2021), 173866.

3. Sheng Wang, Yan Xie, Yanwu Huo, Yan Li, Peter W. Abel, Haihong Jiang, Xiaohan Zou, Haizhan Jiao, Xiaolin Kuang, Dennis W. Wolff, Youguo Huang, Thomas B. Casale, Reynold A. Panettieri Jr., Taotao Wei*, Zhengyu Cao* and Yaping Tu*. Airway relaxation mechanisms and structural basis of osthole to improve lung function in asthma. Science Signaling, 13(2020), eaax0273.（封面论文）

4. Jialing Zhang, Chaoju Hua, Yu Zhang, Peng Wei*, Yaping Tu* and Taotao Wei*. KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression. Cell Death and Disease 11(2020), 732.

5. Li Ma, Shuxin Hu, Xiaolong He, Na Yang, Licui Chen, Chenguang Yang, Fangfu Ye, Taotao Wei* and Ming Li*. Detection of tBid oligomerization and membrane permeabilization by graphene-based single-molecule surface-induced fluorescence attenuation. Nano Letters 19(2019), 6937-6944.

6. Peng Wei, Yan Xie, Peter W. Abel, Yapei Huang, Qin Ma, Linghai Li, Junfeng Hao, Dennis W. Wolff, Taotao Wei* and Yaping Tu*. Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis. Cell Death and Disease 10(2019), 670.

7. Yang Xu, Jinqi Ren, Xiaolong He, Han Chen, Taotao Wei* and Wei Feng*. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy 15(2019), 1017-1030.

8. Yipeng Du, Hao Hu, Xiaoxia Pei, Kang Du and Taotao Wei*. Genetically encoded FapR-NLuc as a biosensor to determine Malonyl-CoA in situ at subcellular scales. Bioconjugate Chemistry 30(2019), 826-832.

9. Yipeng Du*, Hao Hu, Saisi Qu, Jifeng Wang, Chaoju Hua, Jialing Zhang, Peng Wei, Xiaolong He, JunfengHao, Pingsheng Liu, Fuquan Yang, Tingting Li* and Taotao Wei*. SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis inob/ob mice. EBioMedicine 36(2018), 347-357.

10. Ping Zhu, Yongzhang Liu, Fenglin Zhang, Xiufeng Bai, Zilei Chen, FugenShangguan, Bo Zhang, Lingyun Zhang, Qianqian Chen, DeyaoXie, Linhua Lan, XiangdongXue, Xingjie Liang, Bin Lv*, Taotao Wei* and Yan Qin*. Human Elongation Factor 4 regulates cancer bioenergetics by acting as a mitochondrial translation switch. Cancer Research 78(2018), 2813-2824.

11. Bo Zhang, PengWei, Zhixiang Zhou and Taotao Wei*. Interactions of graphene with mammalian cells: Molecular mechanismsand biomedical insights. Advanced Drug Delivery Reviews 105 (2016) 145–162.

12. Chuu-Yun A. Wong, Haihong Jiang, Peter W. Abel, Margaret A. Scofield, Yan Xie, Taotao Wei* and Yaping Tu*. Phorbolmyristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression. Protein & Cell 7(2016), 417-433.

13. Bo Zhang, Wei Chu, Peng Wei, Ying Liu and Taotao Wei*. Xanthohumol induces generation of reactive oxygen species and triggers apoptosis through inhibition of mitochondrial electron transfer chain complex I. Free Radical Biology & Medicine 89(2015), 486-497. 

14. Yipeng Du, Tanxi Cai, Tingting Li, Peng Xue, Bo Zhou, Xiaolong He, Peng Wei, Pingsheng Liu, Fuquan Yang* and Taotao Wei*. Lysine malonylation is elevated in type 2 diabeticmouse models and enriched in metabolicassociated proteins. Molecular & Cellular Proteomics 14(2015), 227-236. 

15. Teng Zhou, Meifang Yu, Bo Zhang, Liming Wang, Xiaochun Wu, Hejiang Zhou, Yipeng Du, JunfengHao, YapingTu, Chunying Chen* and Taotao Wei*. Inhibition of cancer cell migration by gold nanorods: molecular mechanisms and implications for cancer therapy. Advanced Functional Materials 24(2014), 6922-6932.

16. Qianqian Chen, Juan Zhang, Kai Zhao, Wei Li, Qi Miao, Yang Sun, Xingyu Zhao, Taotao Wei* and Fuyu Yang*. Lysosomal chymotrypsin inducesmitochondrial fission in apoptotic cellsby proteolytic activation of calcineurin. Protein & Cell 5(2014), 643-647.

17. Yipeng Du and Taotao Wei*. Inputs and outputs of insulin receptor. Protein & Cell 5(2014), 203-213.

18. Teng Zhou, Bo Zhang, Peng Wei, Yipeng Du, Hejiang Zhou, Meifang Yu, Liang Yan, Wendi Zhang, Guangjun Nie, Chunying Chen, Yaping Tu and Taotao Wei*. Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets. Biomaterials 35(2014), 9833-9843.

19. Hejiang Zhou, Bo Zhang, Jiajia Zheng, Meifang Yu, Teng Zhou, Kai Zhao, YanxiaJia, Xingfa Gao*, Chunying Chen* and Taotao Wei*. The inhibition of migration and invasion of cancer cells by graphenevia the impairment of mitochondrial respiration. Biomaterials 35(2014), 1597-1607.  

20. Wenjuan Duan, Juefei Zhou, Wei Li, Teng Zhou, Qianqian Chen, Fuyu Yang* and Taotao Wei*. Plasma membrane calcium ATPase 4binhibits nitric oxide generation throughcalcium-induced dynamic interaction withneuronal nitric oxide synthase. Protein & Cell 4(2013), 286-298.

21. Kai Zhao, Hejiang Zhou, Xingyu Zhao, Dennis W. Wolff, YapingTu, Huili Liu, Taotao Wei* and Fuyu Yang*. Phosphatidic acid mediates the targeting of tBid toinduce lysosomal membrane permeabilizationand apoptosis. Journal of Lipid Research 53(2012), 2102-2114.

22. Hejiang Zhou, Kai Zhao, Wei Li, Na Yang, Ying Liu, Chunying Chen* and Taotao Wei*. The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways. Biomaterials 33(2012), 6933-6942.

23. Wei Li, Lina Zhao, Taotao Wei*, Yuliang Zhao* and Chunying Chen*. The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles. Biomaterials 32(2011), 4030-4041.

24. Kai Zhao, Xingyu Zhao, YapingTu, Qi Miao, Dongxu Cao, WenjuanDuan, Yang Sun, Jincheng Wang, Taotao Wei* and Fuyu Yang*. Lysosomal chymotrypsin B potentiates apoptosis via cleavageof Bid. Cellular and Molecular Life Sciences 67(2010), 2665-2678.

（资料来源：卫涛涛研究员，2021-10-29）