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脑与认知科学国家重点实验室

李龙博士研究员博士生导师

中科院生物物理所，脑与认知科学国家重点实验室，研究组长

研究方向：抑郁症的神经环路基础与治疗手段；社交奖赏的起源及神经环路基础；出生后压力应激对成年后压力易感性的影响及其分子与环路机制；长期社交及环境压力导致的激素和神经肽受体变化及其功能

电子邮件：longli@ibp.ac.cn

电话：

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_xsszmL/202310/t20231011_378693.html

简历：

　　2006 - 2010 青岛大学，医学院，学士

　　2010 - 2013 中国林业科学研究院，硕士

　　2013 - 2017 中国科学院生物物理研究所，博士

　　2018 - 2022 纽约西奈山伊坎医学院，博士后

　　2022 - 2023 纽约西奈山伊坎医学院，讲师

　　2023 - 至今中国科学院生物物理研究所，研究员，课题组长

获奖及荣誉：

社会任职：

研究方向：

　　抑郁症的神经环路基础与治疗手段；社交奖赏的起源及神经环路基础；出生后压力应激对成年后压力易感性的影响及其分子与环路机制；长期社交及环境压力导致的激素和神经肽受体变化及其功能。

　　实验室围绕社交行为障碍、精神疾病和情感障碍的神经机制开展研究工作。重点关注社交障碍和抑郁症神经环路机制。研究兴趣包括观察奖赏性和创伤性的社会经历如何在发育和环路水平上改变大脑及动物行为，并通过建立新的社交相关的行为范式来剖析不同的社交元素在社交活动中所起到的作用，并在此基础上检测社交功能障碍的分子和环路基础。我们使用转基因小鼠、化学遗传学、光遗传学、电生理学、病毒示踪工具、在体基因编辑、在体神经活动记录、啮齿类动物模型和分子生物学/生物化学方法来了解大脑和身体如何适应压力以调节抑郁和焦虑状态的病理行为。

承担项目情况：

代表论著：

1. Li L, Durand R, Aubry A, Burnett C, Parise L, Cathomas F, Chan K, Yuan C, Morel C, Shimo Y, Lin H, Wang J, Russo S. Social trauma engages lateral septum circuitry to occlude social reward. Nature. 613, 696-703 (2023) https://doi.org/10.1038/s41586-022-05484-5

Research Highlight: Whalley, K. Avoiding social interactions. Nat Rev Neurosci (2022). https://doi.org/10.1038/s41583-022-00668-4

2. Poller, W.C., Downey, J., Mooslechner, A.A., Khan N, Li L, Chan C, McAlpine C, et al. Brain motor and fear circuits regulate leukocytes during acute stress. Nature. 607, 578-584 (2022). https://doi.org/10.1038/s41586-022-04890-z

3. Durand-de Cuttoli R, Martínez-Rivera FJ, Li L, Minier-Toribio A, Holt LM, Cathomas F, Yasmin F, Elhassa SO, Shaikh JF, Ahmed S, Russo SJ, Nestler EJ, Sweis BM. Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice. Science Adv. 2022 Oct 21;8(42):eadd5579. doi: 10.1126/sciadv.add5579. Epub 2022 Oct 19. PMID: 36260683; PMCID: PMC9581472.

4. Takahashi A, Durand-de Cuttoli R, Flanigan ME, Hasegawa E, Tsunematsu T, Aleyasin H, Cherasse Y, Miya K, Okada T, Keino-Masu K, Mitsui K, Li L, Patel V, Blitzer RD, Lazarus M, Tanaka KF, Yamanaka A, Sakurai T, Ogawa S, Russo SJ. Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice. Nat Communication. 2022 Jul 21;13(1):4039. doi: 10.1038/s41467-022-31728-z. PubMed PMID: 35864121; PubMed Central PMCID: PMC9304121.

5. Morel C, Montgomery S, Li L, Durand R, Teichman E, Juarez B, Tzavaras N, Ku S, Flanigan M, Cai M, Walsh J, Russo S, Nestler E, Calipari E, Friedman A, Han M. Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors. Nature Communication 13, 1532 (2022). https://doi.org/10.1038/s41467-022-29155-1

6. Cathomas, F. Bevilacqua, L. Ramakrishnan, A. Kronman, H. Costi, S. Schneider, M. Chan, K. L. Li, L. Nestler, E. J. Shen, L. Charney, D. S. Russo, S. J. Murrough, J. W. Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression. Transl Psychiatry 12, 12 (2022).

7. Takahashi A, Aleyasin H, Stavarache MA, Li L, Cathomas F, Parise LF, Lin HY, Burnett CJ, Aubry A, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Sasaki T, Kaplitt MG, Ogawa S, McEwen BS, Russo SJ. Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression. Mol Psychiatry. 2021 Apr 30. doi: 10.1038/s41380-021-01110-4. PubMed PMID: 33931727.

8. Sun L*, Chen R*, Li L*, Yuan B*, Song K, Pan N, Cheng T, Chang S, Lin K, He X, Wu Q, Xu F, Qiu Z, Wang X. Visualization and correction of social abnormalities-associated neural ensembles in adult MECP2 duplication mice. Science Bulletin. 2020/07; 65(14):1192-1202. (* Equal-contribution)

9. Flanigan ME, Aleyasin H, Li L, Burnett CJ, Chan KL, LeClair KB, Lucas EK, Matikainen-Ankney B, Durand-de Cuttoli R, Takahashi A, Menard C, Pfau ML, Golden SA, Bouchard S, Calipari ES, Nestler EJ, DiLeone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ. Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice. Nat Neurosci. 2020 May;23(5):638-650. doi: 10.1038/s41593-020-0617-7. Epub 2020 Apr 13. PubMed PMID: 32284606; PubMed Central PMCID: PMC7195257.

10. Zhong S, Zhang S, Fan X, Wu Q, Yan L, Dong J, Zhang H, Li L, Sun L, Pan N, Xu X, Tang F, Zhang J, Qiao J, Wang X. A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex. Nature. 2018 Mar 22;555(7697):524-528. doi: 10.1038/nature25980. Epub 2018 Mar 14. PubMed PMID: 29539641.

11. Liu J, Liu W, Yang L, Wu Q, Zhang H, Fang A, Li L, Xu X, Sun L, Zhang J, Tang F, Wang X. The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding. Cell Stem Cell. 2017 Nov 2;21(5):635-649.e8. doi: 10.1016/j.stem.2017.08.013. Epub 2017 Oct 12. PubMed PMID: 29033352.

（资料来源：李龙研究员，2023-09-25）