表观遗传调控与干预重点实验室

1994.09 - 1998.07  烟台大学，学士学位

1998.09 - 2003.07  中国科学院生物物理所，博士研究生

2003.11 - 2005.04  密西根大学，博士后

2005.05 - 2006.07  耶鲁大学医学院，博士后

2006.08 - 2009.07  芝加哥大学，研究助理

2009.07 - 2023.06  中国科学院北京基因组研究所，研究员

2023.06 - 至今       中国科学院生物物理研究所，研究员

2014年  中国科学院青年科学家奖，中国科学院

2014年  杰出青年基金获得者，国家自然科学基金委员会

2014年、2020年  朱李月华导师奖，中国科学院

2015年  第三世界科学院青年通讯会士（TWAS Young Affiliate）

2015年  李汝祺动物遗传奖，中国遗传学会

2015、2016、2019、2020年  中国科学院优秀导师奖，中国科学院

2016年  政府特殊津贴专家，中华人民共和国国务院

2017年  国家百千万人才工程"有突出贡献中青年专家"，中华人民共和国人力资源和社会保障部

2018年  "新时代科技报国"优秀共产党员，中共中国科学院党组

2018年  谈家桢生命科学创新奖，谈家桢生命科学奖奖励委员会

2020年  第八届中国侨界贡献奖，中华全国归国华侨联合会

1.表观遗传信息调控胚胎发育：

表观遗传信息调控基因的表达和胚胎的发育。研究团队在建立新的表观遗传时空组学技术，研究表观遗传信息在胚胎发育和器官建立过程中的重编程动态变化，并揭示调控表观遗传重编程的分子机制，进而解析不同表观遗传调控信息对胚胎发育及器官建立的调控作用。

2. 表观遗传信息在生殖医学的临床应用

团队在国际上首创了使用DNA甲基化筛选胚胎的方法，近期我们在与生殖中心合作进行多中心随机对照临床试验。我们将结合人工智能等方法，建立筛选优质胚胎提高试管婴儿出生率的临床标准。同时我们还研究其它的改善辅助生殖的方法和技术。我们致力于将基础研究转化到临床中，帮助不孕不育患者获得后代，并减少出生缺陷的比例。

1. Chao Ning, Xi Wu, Xudong Zhao, Zongyang Lu, Xuelong Yao, Tao Zhou, Lizhi Yi, Yaoyu Sun, Shuaishuai Wu, Zhenbo Liu, Xingxu Huang*, Lei Gao*, Jiang Liu*. The epigenomic landscapes during prefrontal cortex development and aging in rhesus. National Science Review, 2024, doi.org/10.1093/nsr/nwae213

2. Shenli Yuan, Lei Gao, Wenrong Tao, Jianhong Zhan, Gang Lu, Jingye Zhang, Chuanxin Zhang, Lizhi Yi, Zhenbo Liu, Zhenzhen Hou, Min Dai, Han Zhao, Zi-Jiang Chen*, Jiang Liu*, and Keliang Wu*. Allelic reprogramming of chromatin states in human early embryos. National Science Review, 2024, 11, nwad328.

3. Shenli Yuan, Jianhong Zhan, Jingye Zhang, Zhenbo Liu, Zhenzhen Hou, Chuanxin Zhang, Lizhi Yi, Lei Gao*, Han Zhao*, Zi-Jiang Chen*, Jiang Liu* and Keliang Wu*. Human zygotic genome activation is initiated from paternal genome. Cell discovery. 2023, 9, 13.

4. Keliang Wu, Dongdong Fan, Han Zhao, ZhenboLiu, Zhenzhen Hou, Wenrong Tao, Guanling Yu, Shenli Yuan, Xiaoxiao Zhu, Mengyao Kang, Yong Tian*, Zi-Jiang Chen*, Jiang Liu* and Lei Gao*. Dynamics of histone acetylation during human early embryogenesis. Cell discovery, 2023, 9, 29.

5. Shan Jiang, Zheng Huang, Yun Li, Chengwei Yu, Hao Yu, Yuwen Ke, Lan Jiang*, and Jiang Liu*, Single-cell chromatin accessibility and transcriptome atlas of mouse embryos. Cell reports. 2023, 42, 112210.

6. Yuan Gao*, Lizhi Yi, Jianhong Zhan, Lijuan Wang, Xuelong Yao, Junhao Yan, Sijing Jian, Lei Gao, Mamadboqirova Farangez, Ming Gao, Yang Zou, Xuan Gao, Keliang Wu, Jiang Liu*, and Zi-Jiang Chen*. A clinical study of preimplantation DNA methylation screening in assisted reproductive technology. Cell Research. 2023, May; 33: 483-485

7. Shenli Yuan, Tao Huang,5,6*, Ziyou Bao, Shiyu Wang, Xinyue Wu, Jiang Liu*, Hongbin Liu* and Zi-Jiang Chen*. The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots. Genome biology. 2022 Sep, 23, 187.

8. Xuelong Yao, Zongyang Lu, Zhanying Feng, Lei Gao, Xin Zhou, Min Li, Suijuan Zhong, Qian Wu, Zhenbo Liu, Haofeng Zhang, Zeyuan Liu, Lizhi Yi, Tao Zhou, Xudong Zhao, Jun Zhang, Yong Wang, Xingxu Huang*, Xiaoqun Wang* & Jiang Liu*. Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human. Nat Commun. 2022 Jul 6;131. :3883

9. Xinxin Wang, Xin Ma, Gaobo Wei, Weirui Ma, Zhen Zhang, Xuepeng Chen, Lei Gao, Zhenbo Liu, Yue Yuan, Lizhi Yi, Jun Wang, Toshinobu Tokumoto, Junjiu Huang, Dahua Chen*, Jian Zhang*, and Jiang Liu*. The Role of DNA Methylation Reprogramming During Sex Determination and Transition in Zebrafish. Genomics Proteomics Bioinformatics. 2021 Feb;191. :48-63

10. Tao Huang, Shenli Yuan, Lei Gao, Mengjing Li, Xiaochen Yu, Jianhong Zhang, Yingying Yin, Chao Liu, Chuanxin Zhang, Gang Lu, Wei Li, Jiang Liu*, Zi-Jiang Chen*, Hongbin Liu*. The histone modification reader ZCWPW1 links 1 histone methylation to PRDM9-induced double strand break repair. Elife DOI: 10.7554/eLife.53459

11. Xuepeng Chen, Yuwen Ke, Keliang Wu, Han Zhao, Yaoyu Sun, Lei Gao, Zhenbo Liu, Jingye Zhang, Wenrong Tao, Zhenzhen Hou, Hui Liu, Jiang Liu*, Zi-Jiang Chen*. Key role for CTCF in establishing chromatin structure in human embryos. Nature, 2019, 576：306-310

12. Xiaocui Xu, Guoqiang Li, Congru Li, Jing Zhang, Qiang Wang, David K. Simmons, Xuepeng Chen, Naveen Wijesena, Wei Zhu, Zhanyang Wang, Zhenhua Wang, Bao Ju, Weimin Ci, Xuemei Lu, Daqi Yu, Qian-fei Wang, Neelakanteswar Aluru, Paola Oliveri, Yong E. Zhang, Mark Q. Martindale and Jiang Liu*, Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis. National Science Review, 2019, doi: 10.1093/nsr/nwz064

13. Wei Zhu, Xiaocui Xu, Xinxin Wang and Jiang Liu*. Reprogramming histone modification patterns to coordinate gene expression in early zebrafish embryos. BMC Genomics, 2019, 20:248

14. Congru Li, Yong Fan, Guoqiang Li, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Yang Yu*, Jiang Liu*. DNA methylation reprogramming of functional elements during mammalian embryonic development. Cell Discovery, 2018, 4:41

15. Lei Gao, Keliang Wu, Zhenbo Liu, Xuelong Yao, Shenli Yuan, Wenrong Tao, Lizhi Yi, Guanling Yu, Zhenzhen Hou, Dongdong Fan, Yong Tian, Jianqiao Liu*, Zi-Jiang Chen*, and Jiang Liu*. Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution. Cell, 2018, 173, 248-259

16. Guoqiang Li, Yang Yu, Yong Fan, Congru Li, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao*, Jiang Liu*, Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology, Journal of Genetics and Genomics, 2017, Oct 20; 44 10. : 475-481.

17. Yuwen Ke, Yanan Xu, Xuepeng Chen, Songjie Feng, Zhenbo Liu, Yaoyu Sun, Xuelong Yao, Fangzhen Li, Wei Zhu, Lei Gao, Haojie Chen, Zhenhai Du, Xie Wei, Xiaocui Xu, Xingxu Huang*, Jiang Liu*. 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis, Cell, 2017, Jul 13;1702. :367-381.e20

18. Zhong-Qiang Guo, Tong Zheng, Baoen Chen, Cheng Luo, Sisheng Ouyang, Shouzhe Gong, Jiafei Li, Liu-Liang Mao, Fulin Lian, Yong Yang, Yue Huang, Li Li, Jing Lu, Bidong Zhang, Luming Zhou, Hong Ding, Zhiwei Gao, Liqun Zhou, Guoqiang Li, Ran Zhou, Ke Chen, Jingqiu Liu, Yi Wen, Likun Gong, Yuwen Ke, Shang-Dong Yang, Xiao-Bo Qiu, Naixia Zhang, Jin Ren, Dafang Zhong, Cai-Guang Yang, * Jiang Liu,* and Hualiang Jiang*. Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer, Cancer Cell, 2016, 303. , 474-484 highlighted by Nature Reviews Urology.

19. Yunfang Wang*, Jinhua Qin, Shuyong Wang, Wencheng Zhang, Jialei Duan, Jing Zhang, Xin Wang, Fang Yan, Mingyang Chang, Xiaofang Liu, Bo Feng, Jiang Liu*, Xuetao Pei*, Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules, Cell Stem Cell, 2016, Oct 6; 19 4. ; 449-461, * co-senior author

20. Ke Chen, Jing Zhang, Zhongqiang Guo, Qin Ma, Zhengzheng Xu, Yuanyuan Zhou, Zhiying Xu, Zhongwu Li, Yiqiang Liu, Xiongjun Ye, Xuesong Li, Bifeng Yuan, Yuwen Ke, Chuan He, Liqun Zhou*, Jiang Liu* and Weimin Ci*. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer, Cell Research, 2016, Jan;261. :103-18

21. Lu Wang, Jun Zhang, Jialei Duan, Xinxing Gao, Wei Zhu, Xingyu Lu, Lu Yang, Jing Zhang, Guoqiang Li, Weimin Ci, Wei Li, Qi Zhou, Neel Aluru, Fuchou Tang, Chuan He, Xingxu Huang*, Jiang Liu*，Programming and inheritance of parental DNA methylomes in mammals，Cell, 2014, 1574. ,979-991

22. Guoqiang Li, Weimin Ci, Subhradip Karmakar, Ke Chen, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Xianghong Li, Erin E. Mowers, Matthew F. Calabrese, Edmond R. Watson, Sandip Prasad, Carrie Rinker-Schaeffer, Scott E. Eggener, Thomas Stricker, Yong Tian, Brenda Schulman, Jiang Liu*, Kevin P. White*, SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer, Cancer Cell, 2014,254. , 455-468, IF，25）

23. Lan Jiang, Jing Zhang, Jing-Jing Wang, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci*, Jiang Liu*.  Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos, Cell, 2013, 1534. , 773-84, Cover story， highlighted by Cell, Nature Review Genetics）

24. Jiang Liu^#, Murad Ghanim^#, Lei Xue^#, Ivan Iossifov, Cesar Angeletti, Sujun Hua, Nicolas Negre, Michael Ludwig, Thomas Stricker, Hikmat A. Al-Ahmadie, Maria Tretiakova, Robert L. Camp, Montse Perera-Alberto, David L. Rimm, Tian Xu, Andrey Rzhetsky and Kevin P. White*. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer, Science, 2009.3235918. :1218-1222

（资料来源：刘江研究员，2024-08-28）