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创新研究群体项目获得者

田勇（兼）博士研究员博士生导师

表观遗传调控与干预重点实验室，研究组长
中科院生物物理研究所动物实验中心主任
中国科学院动物实验平台工作委员会主任
中国科学院大学岗位教授
中国科学院实验动物资源网负责人

研究方向：表观基因编辑

电子邮件：ytian@ibp.ac.cn

电话：010-64888579

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_xsszmQ_V/202005/t20200519_341384.html

中国科学院实验动物资源网：http://www.lar.ac.cn/

简历：

田勇：中国科学院生物物理研究所二级研究员，博士生导师，“十四五”科技部国家重点研发计划“基础科研条件与重大科学仪器设备研发”项目首席科学家。目前担任中国科学院生物物理研究所动物实验中心主任，中国科学院表观遗传调控与干预重点实验室课题组长，中国科学院大学医学院岗位教授，中国科学院动物实验平台工作委员会主任，中国科学院实验动物资源网负责人，中国实验动物学会副理事长，《Animal Models and Experimental Medicine》杂志副主编，《Mammalian Genome》杂志编委，《生物化学与生物物理学进展》杂志常务编委，全国实验动物标准化技术委员会委员。主持多项基金委、科技部和中国科学院等科研项目，近五年以来以通讯作者/共通讯作者身份在Immunity (2022), Cell Research (2022, 2020) , Neuron (2022), Nature Immunology (2019, 2018, 2017, 2016), Nucleic Acids Research (2023，2022)，Molecular Cancer (2021)，Nature Communications (2022，2021, 2020, 2019, 2018, 2017), Cellular & Molecular Immunology (2022，2021), Cell Discovery (2023), The EMBO Journal (2023, 2020, 2019, 2018) , Journal of Hepatology (2018), Journal of Experimental Medicine (2019a，2019b), Cell Reports (2019)和Life Medicine (2022)等国际一流学术刊物上发表多篇SCI研究论文。近年多次在IMPC（2022, 2021）, AMMRA（2021，2019）等国际实验动物学术会议上做大会报告，荣获2020年中国实验动物学会科学技术奖一等奖。

获奖及荣誉：

社会任职：

研究方向：

1. 围绕消化道肿瘤、免疫性疾病和神经退行性疾病，利用基因编辑技术构建大小鼠实验动物模型并开展发病机制研究；

2. 基因编辑技术（CRISPR/Cas9）在模式生物疾病动物模型研发中的应用研究；

3. 利用动物模型开展非编码核酸（lncRNA）和环形RNA (circRNA) 在体功能的研究。

承担项目情况：

代表论著：

1. Zhu P, Lu T, Chen Z, Liu B, Fan D, Li C, Wu J, He L, Zhu X, Du Y, Tian Y*, Fan Z*. 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Neuron. 2022 May 7;S0896-6273(22)00369-5. doi: 10.1016/j.neuron.2022.04.024.

2. Zhu P, Lu T, Wu J, Fan D, Liu B, Zhu X, Guo H, Du Y, Liu F, Tian Y*, Fan Z*. Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons. Cell Res. 2022 Apr 4. doi: 10.1038/s41422-022-00645-7.

3. Xiong Z, Zhu X, Geng J, Xu Y, Wu R, Li C, Fan D, Qin X, Du Y, Tian Y*, Fan Z*. Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine. Immunity. 2022 Apr 12;55(4):686-700.e7. doi: 10.1016/j.immuni.2022.03.001.

4. Ye B, Yang L, Liu B, Liu N, Fan D, Li H, Sun L, Du Y, Wang S, Tian Y*, Fan Z*. Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity. Cell Mol Immunol. 2022 May;19(5):619-633. doi: 10.1038/s41423-022-00842-9.

5. Song G, Zhang F, Tian C, Gao X, Zhu X, Fan D, Tian Y*. Discovery of potent and versatile CRISPR-Cas9 inhibitors engineered for chemically controllable genome editing. Nucleic Acids Res. 2022 Mar 21;50(5):2836-2853. doi: 10.1093/nar/gkac099.

6. Liu N, He J, Fan D, Gu Y, Wang J, Li H, Zhu X, Du Y, Tian Y*, Liu B*, Fan Z*. Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. Nat Commun. 2022 Aug 11;13(1):4711. doi: 10.1038/s41467-022-32322-z.

7. Song G, Ma Y, Gao X, Zhang X, Zhang F, Tian C, Hou J, Liu Z, Zhao Z, Tian Y*. CRISPR/Cas9-mediated Genetic Correction Reverses Spinocerebellar Ataxia 3 Disease-associated Phenotypes in Differentiated Cerebellar Neurons. Life Med. 2022.doi: 10.1093/lifemedi/lnac020.

8. Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y*, Yi C*, Fan Z*. N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun. 2021 Nov 2;12(1):6314. doi: 10.1038/s41467-021-26718-6.

9. Gu Y, Wang Y, He L, Zhang J, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y*, Fan Z*. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Mol Cancer. 2021 Oct 14;20(1):132. doi: 10.1186/s12943-021-01435-2.

10. Liu B, Liu N, Zhu X, Yang L, Ye B, Li H, Zhu P, Lu T, Tian Y*, Fan Z*. Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA. Cell Mol Immunol. 2021 Jun;18(6):1412-1424. doi: 10.1038/s41423-021-00680-1.

11. Su R, Fan LH, Cao C, Wang L, Du Z, Cai Z, Ouyang YC, Wang Y, Zhou Q, Wu L, Zhang N, Zhu X, Lei WL, Zhao H, Tian Y, He S, Wong CCL, Sun QY, Xue Y. Global profiling of RNA-binding protein target sites by LACE-seq. Nat Cell Biol. 2021 Jun;23(6):664-675. doi: 10.1038/s41556-021-00696-9.

12. Liu B, Ye B, Zhu X, Yang L, Li H, Liu N, Zhu P, Lu T, He L, Tian Y*, Fan Z*. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. Nat Commun. 2020 Aug 14;11(1):4076. doi: 10.1038/s41467-020-17944-5.

13 Ye B, Yang L, Qian G, Liu B, Zhu X, Zhu P, Ma J, Xie W, Li H, Lu T, Wang Y, Wang S, Du Y, Wang Z, Jiang J, Li J, Fan D, Meng S, Wu J, Tian Y*, Fan Z.*. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. EMBO J. 2020 Jul 1;39(13):e103786. doi: 10.15252/embj.2019103786.

14. Wang S, Qu Y, Xia P, Chen Y, Zhu X, Zhang J, Wang G, Tian Y*, Ying J*, Fan Z*. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. Cell Res. 2020 Jul;30(7):610-622. doi: 10.1038/s41422-020-0312-y.

15. Song G, Zhang F, Zhang X, Gao X, Zhu X, Fan D, Tian Y*. AcrIIA5 Inhibits a Broad Range of Cas9 Orthologs by Preventing DNA Target Cleavage. Cell Rep. 2019 Nov 26;29(9):2579-2589.e4. doi: 10.1016/j.celrep.2019.10.078.

16. Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, Qin X, Qu Y, He L, Fan D, Du Y, Tian Y*, Fan Z*. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. J Exp Med. 2020 Feb 3;217(2). pii: e20190974. doi: 10.1084/jem.20190974.

17. Liu B, Yang L, Zhu X, Li H, Zhu P, Wu J, Lu T, He L, Liu N, Meng S, Zhou L, Ye B, Tian Y*, Fan Z*. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. J Exp Med. 2019 Nov 4;216(11):2653-2668. doi: 10.1084/jem.20182363.

18. Zhang F, Song G, Tian Y*. Anti-CRISPRs: The natural inhibitors for CRISPR-Cas systems. Animal Model Exp Med. 2019 May 29;2(2):69-75. doi: 10.1002/ame2.12069.

19. Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Ren W, Wang J, Sun X, Chen R, Tian Y*, Fan Z*. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. EMBO J. 2019 Sep 2;38(17):e101110. doi: 10.15252/embj.2018101110.

20. Zhu P, Zhu X, Wu J, He L, Lu T, Wang Y, Liu B, Ye B, Sun L, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y*, Fan Z*. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 2019 Feb;20(2):183-194. doi: 10.1038/s41590-018-0297-6.

21. Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y*, Fan Z*. LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis. Nat Cell Biol. 2018 Sep 17. doi: 10.1038/s41556-018-0194-0.

22. Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S, Wu J, Ye B, He L, Du Y, He L, Chen R, Tian Y*, Fan Z*. Long noncoding RNA lncHand2 promotes liver repopulation via initiating Nkx1-2-induced c-Met signaling. J Hepatol. 2018 Oct; 69(4):861-872. doi: 10.1016/j.jhep.2018.03.029.

23. Gao L, Wu K, Liu Z, Yao X, Yuan S, Tao W, Yi L, Yu G, Hou Z, Fan D, Tian Y, Liu J, Chen ZJ, Liu J. Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution. Cell. 2018 Mar 22;173(1):248-259.e15. doi: 10.1016/j.cell.2018.02.028.

24. Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y*, Fan Z*. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261. doi: 10.1038/s41467-018-03008-2.

25. Ye B, Liu B, Yang L, Zhu X, Zhang D, Wu W, Zhu P, Wang Y, Wang S, Xia P, Du Y, Meng S, Huang G, Wu J, Chen R*, Tian Y*, Fan Z*. LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3. EMBO J. 2018 Mar 13. pii: e97174. doi: 10.15252/embj.201797174.

26. Xia P, Wang S, Xiong Z, Zhu X, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y*, Fan Z*. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nat Immunol. 2018 Jan 1. doi: 10.1038/s41590-017-0014-x.

27. Liu B, Ye B, Zhu X, Huang G, Zhu P, Yang L, Du Y, Wu J, Meng S, Tian Y*, Fan Z*. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Nat Commun. 2017 Aug 10. doi:10.1038/s41467-017-00235-x.

28. Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, Du Y, Wu J, Qin X, Chen R*, Tian Y*, Fan Z*. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression. Nat Immunol. 2017 Mar 20. doi: 10.1038/ni.3712.

29. Xia P, Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y*, Fan Z*. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016 Feb 1. doi: 10.1038/ni.3356.

30. Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, Fan Z. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015 Apr 2;16(4):413-25. doi: 10.1016/j.stem.2015.03.003.

31. Chen J, Hao L, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li P, Tian Y*, Fan Z*. The endoplasmic reticulum adaptor protein ERAdP initiates NK cell activation via the Ubc13-mediated NF-κB pathway. J Immunol. 2015 Feb 1;194(3):1292-303. doi: 10.4049/jimmunol.1402593.

32. Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y*, Fan Z*. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014 Nov 17;211(12):2439-54. doi: 10.1084/jem.20141123.

33. Zhu X, Xu Y, Yu S, Lu L, Ding M, Cheng J, Song G, Gao X, Yao L, Fan D, Meng S, Zhang X, Hu S*, Tian Y*. An efficient genotyping method for genome-modified animals and human cells generated with CRISPR/Cas9 system. Sci Rep. 2014 Sep 19;4:6420. doi: 10.1038/srep06420.

34. Li G, Ci W, Karmakar S, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J, White KP. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell. 2014 Apr 14;25(4):455-68. doi: 10.1016/j.ccr.2014.02.007.

35. Han J, Li J, Jia W, Yao L, Li X, Jiang L*, Tian Y*. Photothermal therapy of cancer cells using novel hollow gold nanoflowers. Int J Nanomedicine. 2014 Jan 16;9:517-26. doi: 10.2147/IJN.S55800.

（资料来源：田勇研究员，2024-07-03）