卫涛涛 / 博士 研究员 博士生导师
中国科学院生物物理研究所,生物大分子重点实验室,研究组长
研究方向:细胞能量代谢
电子邮件:weitt@ibp.ac.cn
电  话:010-64888566
英文版个人网页:http://english.ibp.cas.cn/sourcedb/rck/EN_xsszmW/202005/t20200519_341373.html
简历

1989 - 1993  华中科技大学化学系,学士

1993 - 1996  湖北省化学研究所,硕士

1996 - 1999  中国科学院生物物理研究所,博士

1999 - 2001  中国科学院生物物理研究所,助理研究员

2001 - 2008  中国科学院生物物理研究所,副研究员

2008 - 至今   中国科学院生物物理研究所,研究员

获奖及荣誉

2020年  《细胞生物学》课程被认定为国家一流本科课程

2021年  中国科学院大学领雁金奖--引航奖

2021年  江西省自然科学二等奖

2022年  中国科学院大学领雁银奖--振翅奖

2023年  中国科学院大学李佩优秀教师奖

社会任职

中国生物物理学会理事

中国生物物理学会膜生物学分会秘书长

中华预防医学会自由基预防医学专业委员会常务委员

中国生物物理学会自由基生物学分会理事

中国抗癌协会纳米肿瘤学专业委员会委员

《生物化学与生物物理进展》常务编委

承担项目情况

  线粒体是细胞的能量代谢中心,也是细胞命运决定的调控中枢之一。在正常生理条件下,线粒体网络不断发生动态变化、实现稳态维持,通过进行能量代谢与物质代谢维持细胞生命活动;在特定病理条件下,线粒体稳态被破坏,直接影响线粒体的功能,对生命过程造成显著影响。本课题组结合结构生物学、单分子生物物理学、蛋白组学及修饰组学等技术手段发现了多种维持线粒体稳态的蛋白质机器,解析了它们影响细胞命运决定的分子机制,并揭示了它们参与代谢性疾病及恶性肿瘤发生发展的重要作用;还构建了一系列靶向线粒体、调控细胞能量代谢并有效阻遏肿瘤的纳米生物材料。

研究论文(*通讯作者)

1. Yanwu Huo*, Lingfei Kong, Ye Zhang, Min Xiao, Sunyuntao Xu, Xiaoxue Yan, Jun Ma*, Taotao Wei*. Structural and biochemical insights into the mechanism of the Gabija bacterial immunity system. Nature Communications, 15(2024), 836.

2. Hong-Yu Li, Min Wang, Xiaoyu Jiang, Yaobin Jing, Zeming Wu, Yifang He, Kaowen Yan, Shuhui Sun, Shuai Ma, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu*, Weiqi Zhang*, Taotao Wei* and Guang-Hui Liu*. CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver. Nucleic Acids Research, (2024), doi.org/10.1093/nar/gkae740.

3. Jialing Zhang, Chaoju Hua, Yu Zhang, Peng Wei*, Yaping Tu*and Taotao Wei*. KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression. Cell Death and Disease 11(2020), 732.

4. Sheng Wang, Yan Xie, Yanwu Huo, Yan Li, Peter W. Abel, Haihong Jiang, Xiaohan Zou, Haizhan Jiao, Xiaolin Kuang, Dennis W. Wolff, Youguo Huang, Thomas B. Casale, Reynold A. Panettieri Jr., Taotao Wei*, Zhengyu Cao* and Yaping Tu*. Airway relaxation mechanisms and structural basis of osthole to improve lung function in asthma. Science Signaling, 13(2020), eaax0273.(封面论文)

5. Li Ma, Shuxin Hu, Xiaolong He, Na Yang, Licui Chen, Chenguang Yang, Fangfu Ye, Taotao Wei* and Ming Li*. Detection of tBid oligomerization and membrane permeabilization by graphene-based single-molecule surface-induced fluorescence attenuation. Nano Letters 19(2019), 6937-6944.

6. Peng Wei, Yan Xie, Peter W. Abel, Yapei Huang, Qin Ma, Linghai Li, Junfeng Hao, Dennis W. Wolff, Taotao Wei* and Yaping Tu*. Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis. Cell Death and Disease 10(2019), 670.

7. Yang Xu, Jinqi Ren, Xiaolong He, Han Chen, Taotao Wei* and Wei Feng*. YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy 15(2019), 1017-1030.

8. Yipeng Du, Hao Hu, Xiaoxia Pei, Kang Du and Taotao Wei*. Genetically encoded FapR-NLuc as a biosensor to determine Malonyl-CoA in situ at subcellular scales. Bioconjugate Chemistry 30(2019), 826-832.

9. Yipeng Du*, Hao Hu, Saisi Qu, Jifeng Wang, Chaoju Hua, Jialing Zhang, Peng Wei, Xiaolong He, Junfeng Hao, Pingsheng Liu, Fuquan Yang, Tingting Li* and Taotao Wei*. SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice. EBioMedicine 36(2018), 347-357.

10. Ping Zhu, Yongzhang Liu, Fenglin Zhang, Xiufeng Bai, Zilei Chen, Fugen Shangguan, Bo Zhang, Lingyun Zhang, Qianqian Chen, Deyao Xie, Linhua Lan, Xiangdong Xue, Xingjie Liang, Bin Lv*, Taotao Wei* and Yan Qin*. Human Elongation Factor 4 regulates cancer bioenergetics by acting as a mitochondrial translation switch. Cancer Research 78(2018), 2813-2824.

综述(*通讯作者)

1. Hejiang Zhou*, Yanwu Huo, Na Yang, Taotao Wei*. Phosphatidic acid: from biophysical properties to diverse functions. The FEBS Journal, 291(2024), 1870-1885.

2. 卫涛涛*,陈佺*,徐涛*,陈晔光*. 中国细胞器互作研究的进展和趋势. 中国科学:生命科学, 52(2022), 1-4.

3. Bo Zhang, PengWei, Zhixiang Zhou and Taotao Wei*. Interactions of graphene with mammalian cells: Molecular mechanisms and biomedical insights. Advanced Drug Delivery Reviews 105 (2016) 145-162.

4. Yipeng Du and Taotao Wei*. Inputs and outputs of insulin receptor. Protein & Cell 5(2014), 203-213.

(资料来源:卫涛涛研究员,2024-09-12)