蛋白质生物成像中心
  • 朱平

    邮箱:zhup(AT)ibp.ac.cn
    座机:010-64888799

个人简介

  1986.09 - 1990.06 浙江大学 学士

  1990.09 - 1993.06 西安交通大学 硕士

  1993.09 - 1997.06 清华大学 博士

  1997.07 - 1998.12 清华大学 讲师

  1999.03 - 2008.05 美国佛罗里达州立大学生物系 博士后、助理研究员、副研究员(Non tenure-track faculty系列)

  2008.06 - 至今 中国科学院生物物理研究所 课题组长

  2014 获国家“杰出青年科学基金”资助

  研究方向:基于冷冻电镜(Cryo-EM)技术的生物大分子结构与功能研究

  代表性论文及论著

  1. Zhu P*, Li G*. (2016) Higher-order structure of the 30-nm chromatin fiber revealed by cryo-EM. IUBMB Life. 68(11):873-78 (*corresponding author, invited review, cover)

  2. Xu P, Li C, Chen Z, Jiang S, Fan S, Wang J, Dai J, Zhu P*, Chen Z*. (2016) The NuA4 core complex acetylates nucleosomal histone H4 through a double recognition mechanism, Mol. Cell, 63:965–75 (*corresponding author)

  3. Zhu P*, Li G*. (2016) Structural insights of nucleosome and the 30-nm chromatin fiber. Curr. Opin.Struc. Biol., 36:106-15 (*corresponding author, invited review)

  4. Zhu HT, Zhu P*. (2015) No longer ‘blob-ology’: Cryo-EM is getting into molecular details. Sci China Life Sci, 58(11): 1154-6 (*corresponding author, insight)

  5. Li C, Zhou M, Li X, Zhu P*. (2015) Application of cryo-electron microscopy on epigenetic studies. Prog. in Biochem. & Biophys. 42(11):1063-72 (*corresponding author, in Chinese, invited review)

  6. Li X, Feng H, Zhang J, Sun L, Zhu P*. (2015) Analysis of Chromatin Fiber in Hela Cell with Electron Tomography. Biophys. Report, 1(1): 51-60 (*corresponding author, cover story)

  7. Li Z, Qi X, Ren X, Cui L, Wang X*, Zhu P*. (2015) Molecular characteristics and evolutionary analysis of a very virulent infectious bursal disease virus. Sci China Life Sci, 58(8): 731-38 (*corresponding author, cover story)

  8. Li G*, Zhu P*. (2015) Structure and organization of chromatin fiber in the nucleus. FEBS Lett., doi:10.1016/j.febslet.2015.04.023, published online Ahead-of-Print (*corresponding author, invited review)

  9. Yao Q, Lu Q, Wan X, Song F, Xu Y, Hu M, Zamyatina A, Liu X, Huang N, Zhu P*, Shao F*. (2014) A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family. elife. 3:e03714 (*corresponding author)

  10. Gong M, Zhu H, Zhou J, Yang C, Feng J, Huang X, Ji G, Xu H*, Zhu P*. (2014) Cryo-EM study of insect cell-expressed Enterovirus 71 and Coxsackievirus A16 virus-like particles provides a structural basis for vaccine development. J. Virol., 88(11):6444-52 (*corresponding author)

  11. Song F, Chen P, Sun D, Wang M, Dong L, Liang D, Xu RM, Zhu P*, Li G*. (2014) Cryo-EM study of the chromatin fiber reveals a double helix twisted by tetranucleosomal units. Science. 344 (6182): 376-80 (*corresponding author, Research Article)

  12. Cheng L, Huang X, Li X, Xiong W, Sun W, Yang C, Zhang K, Wang Y, Liu H, Huang X, Ji G, Sun F, Zheng C*, Zhu P*. (2014) Cryo-EM structures of two bovine adenovirus type 3 intermediates. Virology, 450-451:174-81 (*corresponding author)

  13. Zhu H, Zhuang J, Feng H, Liang R, Wang J, Xie L*, Zhu P*. (2014) Cryo-EM structure of isomeric molluscan hemocyanin triggered by viral infection. PLoS One, 9(6): e98766 (*corresponding author)

  14. Sun D, Song F, Huang L, Zhang K, Ji G, Chen P*, Zhu P*. (2013) In vitro Assembly and Electron Microscopic Analysis of 30 nm Chromatin Fibers. Prog. in Biochem. & Biophys. 2013, 40(7): 739-47 (*corresponding author, in Chinese, cover story)

  15. Yang C, Ji G, Liu H, Zhang K, Liu G, Sun F, Zhu P*, Cheng L*. (2012) Cryo-EM Structure of a transcribing cypovirus. Proc. Natl. Acad. Sci. USA, 109(16):6118-23 (*corresponding author)

  16. Cheng L, Sun J, Zhang K, Mou Z, Huang X, Ji G, Sun F, Zhang J*, Zhu P*. (2011) Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping. Proc. Natl. Acad. Sci. USA, 108(4):1373–78 (* corresponding author)

  17. Zhu P, Winkler H, Chertova E, Taylor K, Roux K. (2008) Cryoelectron tomography of HIV-1 envelope spikes: further evidence for tripod-like legs. PLoS Pathog. 4(11): e1000203.

  18. Zhu P, Liu J, Bess J., Chertova E, Lifson J, Grisé H, Ofek G, Taylor K, Roux K. (2006) Distribution and Three-Dimensional Structure of AIDS Virus Envelope Spikes. Nature. 441:847-852 (Article)

  19. Zhu P, Chertova E., Bess J, Lifson J, Arthur L, Liu J, Taylor KA, Roux KH. (2003) Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. Proc. Natl. Acad. Sci. USA, 100(26):15812-15817

  20. Zhu P, Olson WC, Roux KH. (2001) Structural Flexibility and Function Valency of CD4-IgG2 (PRO 542): Potential for Crosslinking HIV-1 Envelope Spikes, J Virol., 75(14):6682-6686.

 

 

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